Pyridazine derivatives as RORc modulators

ABSTRACT

Compounds of formula I: 
                         
or pharmaceutical salts thereof,
 
wherein m, n, A, R1, R 2 , R 3 , R 4  and R 5  are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

CROSS REFERENCE TO RELATED APPLICATIONS

This Application is a continuation of International Application No. PCT/EP2016/059809 filed on May 3, 2016, which is entitled to the benefit U.S. Provisional Application No. 62/156,605 filed on May 4, 2015, the disclosures of which are incorporated herein by reference.

FIELD OF THE INVENTION

The invention pertains to compounds that modulate the function of retinoid-receptor related orphan receptor RORc (RORγ) and use of such compounds for treatment of autoimmune diseases

BACKGROUND OF THE INVENTION

T helper 17 cells (Th17) are interleukin (IL)-17 secreting CD4+ T cells involved in pathogenesis of autoimmune diseases such as rheumatoid arthritis, irritable bowel disease, psoriasis, psoriatic arthritis and spondyloarthridities. The retinoic acid-related orphan receptor γ (RORγ or RORc) is recognized as a transcription factor necessary for Th17 cell differentiation. RORc is an orphan member of the nuclear hormone receptor subfamily that includes RORα (RORa) and RORβ (RORb). RORc controls gene transcription by binding to DNA as a monomer. Selective modulation of RORc has been proposed as a route to discovery and development of Th17 cell-associated autoimmune diseases.

There is accordingly a need for compounds that inhibit RORc for use in treatment of autoimmune diseases such as rheumatoid arthritis, irritable bowel disease, psoriasis, psoriatic arthritis and spondyloarthridities.

SUMMARY OF THE INVENTION

The invention provides compounds of formula I:

or pharmaceutical salts thereof, wherein:

-   A is:     -   a six membered hetereoaryl selected from: pyridinyl;         pyrimidinyl; pyrazinyl; pyridazinyl; and triazinyl; -   m is: 0; 1; or 2; -   n is: 0; or 1; -   R¹ is:     -   halo; -   R² is:     -   hydrogen; or     -   halo; -   R³ is:     -   hydrogen;     -   C₁₋₆alkyl; or     -   halo; -   R⁴ is:     -   C₁₋₆alkyl;     -   oxo;     -   hydroxy;     -   C₁₋₆alkyoxy;     -   C₁₋₆alkyoxycarbonyl;     -   halo-C₁₋₆alkyl;     -   cyano; or     -   halo; -   R⁵ is:     -   heteroaryl selected from pyridinyl, pyrimidinyl, pyrazinyl,         pyridazinyl, oxadiazolyl, triazolyl, oxazolyl, tetrazolyl,         imidazolyl, pyrazolyl, isoxazolyl, thiazolyl, isothiazolyl and         thiadiazolyl, each of which may be unsubstituted or substituted         once or twice with R^(a);     -   heterocyclyl selected from azetidinyl, oxetanyl, pyrrolidinyl,         imidazolidinyl, morpholinyl, 1-oxa-6-azaspiro[3.3]heptanyl,         piperazinyl, piperidinyl, pyrrolidinyl, imidazolinidinyl,         tetrahydropyranyl, tetrahydrofuranyl, tetrahydrotriazinyl,         thiomorpolinyl, 1,1-dioxo-thiomorpholinyl, and dihydropyridinyl,         each of which may be unsubstituted or substituted once or twice         with R^(a);     -   cyano;     -   —NR^(b)R^(c);     -   —C₁₋₆alkylene-NR^(b)R^(c);     -   —OR^(d);     -   —C(O)NR^(e)R^(f);     -   —SO₂NR^(e)R^(f);     -   —C(O)OR^(g); or     -   hydroxy-C₁₋₆alkyl; -   R^(a) is:     -   C₁₋₆alkyl;     -   C₁₋₆alkenyl;     -   C₁₋₆alkynyl;     -   amino;     -   cyano;     -   cyano-C₁₋₆alkyl;     -   hydroxy;     -   oxo;     -   halo;     -   halo-C₁₋₆alkyl;     -   hydroxy-C₁₋₆alkyl;     -   hydroxy-C₁₋₆alkoxy;     -   hydroxy-C₁₋₆alkyl substituted with halo;     -   hydroxy-C₁₋₆alkoxy substituted with halo;     -   aminocarbonyl;     -   aminocarbonyl-C₁₋₆alkyl;     -   aminocarbonyl-C₁₋₆alkoxy;     -   hydroxy-C₁₋₆alkylaminocarbonyl;     -   C₁₋₆alkylcarbonyl;     -   hydroxy-C₁₋₆alkylcarbonyl;     -   C₃₋₆cycloalkyl which may be unsubstituted or substituted once         with R^(h);     -   C₁₋₆alkyoxycarbonyl;     -   C₁₋₆alkylsulfonyl;     -   C₁₋₆alkylsulfonyl-C₁₋₆alkyl;     -   C₃₋₆cycloalkylsulfonyl;     -   C₃₋₆cycloalkylsulfonyl-C₁₋₆alkyl;     -   C₃₋₆cycloalkyl-C₁₋₆alkylsulfonyl;     -   C₃₋₆cycloalkyl-C₁₋₆alkylsulfonyl-C₁₋₆alkyl;     -   oxetanyl which may be unsubstituted or substituted once with         R^(h); -   R^(b) is:     -   hydrogen; or     -   C₁₋₆alkyl; -   R^(c) is:     -   hydrogen;     -   C₁₋₆alkyl;     -   halo-C₁₋₆alkyl;     -   cyano-C₁₋₆alkyl;     -   C₁₋₆alkylcarbonyl;     -   hydroxy-C₁₋₆alkylcarbonyl;     -   oxetanylcarbonyl;     -   oxetanylsulfonyl;     -   C₁₋₆alkylsulfonyl;     -   C₁₋₆alkylsulfonyl-C₁₋₆alkyl;     -   hydroxyl-C₁₋₆alkyl;     -   C₁₋₆alkyoxy-C₁₋₆alkyl;     -   C₃₋₆cycloalkyl which may be unsubstituted or substituted once         with R^(h);     -   C₃₋₆cycloalkyl-C₁₋₆alkyl wherein the C₃₋₆cycloalkyl may be         unsubstituted or substituted once with R^(h);     -   heterocyclyl selected from oxetanyl, azetidinyl, morpholinyl and         tetrahydrofuranyl, each of which may be unsubstituted or         substituted once or twice with R^(h);     -   heterocyclyl-C₁₋₆alkyl wherein the heterocyclyl is selected from         oxetanyl and azetidinyl, each of which may be unsubstituted or         substituted once with R^(h);     -   heteroaryl selected from pyrazinyl and triazolyl, each of which         may be unsubstituted or substituted once or twice with R^(h); or     -   heteroaryl-C₁₋₆alkyl wherein the heteroaryl is selected from         pyrazinyl and triazolyl, each of which may be unsubstituted or         substituted once or twice with R^(h);     -   or R^(b) and R^(c) together with the nitrogen atom to which they         are attached may form heterocyclyl selected from azetidinyl,         pyrrolidinyl, piperidinyl, piperazinyl, azepinyl, morpholinyl,         thiomorpholinyl, and 1,1-dioxothiomorpholinyl, each of which         heterocylcles may be unsubstituted or substituted once with         R^(h); -   R^(d) is:     -   C₁₋₆alkyl;     -   hydroxy-C₁₋₆alkyl;     -   C₁₋₆alkyoxy-C₁₋₆alkyl;     -   aminocarbonyl-C₁₋₆alkyl; or     -   heteroaryl selected from pyridinyl, pyrimidinyl and pyrazinyl; -   R^(e) is:     -   hydrogen;     -   C₁₋₆alkyl; or     -   hydroxy-C₁₋₆alkyl; -   R^(f) is:     -   hydrogen;     -   C₁₋₆alkyl;     -   halo-C₁₋₆alkyl;     -   cyano-C₁₋₆alkyl;     -   hydroxyl-C₁₋₆alkyl;     -   C₁₋₆alkyoxy;     -   C₁₋₆alkyoxy-C₁₋₆alkyl;     -   C₁₋₆alkylsulfonyl-C₁₋₆alkyl;     -   C₃₋₆cycloalkyl which may be unsubstituted or substituted once         with R^(h);     -   C₃₋₆cycloalkyl-C₁₋₆alkyl wherein the C₃₋₆cycloalkyl may be         unsubstituted or substituted once with R^(h);     -   heterocyclyl selected from oxetanyl, azetidinyl, morpholinyl and         tetrahydrofuranyl, each of which may be unsubstituted or         substituted once or twice with R^(h);     -   heterocyclyl-C₁₋₆alkyl wherein the heterocyclyl is selected from         oxetanyl and azetidinyl, each of which may be unsubstituted or         substituted once with R^(h);     -   heteroaryl selected from pyrazinyl and triazolyl, each of which         may be unsubstituted or substituted once or twice with R^(h); or     -   heteroaryl-C₁₋₆alkyl wherein the heteroaryl is selected from         pyrazinyl and triazolyl, each of which may be unsubstituted or         substituted once or twice with R^(h);     -   or R^(e) and R^(f) together with the nitrogen atom to which they         are attached may form heterocyclyl selected from azetidinyl,         pyrrolidinyl, piperidinyl, piperazinyl, azepinyl, morpholinyl,         thiomorpholinyl, and 1,1-dioxothiomorpholinyl, each of which         heterocylcles may be unsubstituted or substituted once with         R^(h); -   R^(g) is:     -   hydrogen; or     -   C₁₋₆alkyl; -   R^(h) is:     -   C₁₋₆alkyl;     -   cyano;     -   hydroxy;     -   aminocarbonyl;     -   oxo; or     -   hydroxy-C₁₋₆alkyl;     -   provided that the compound is not:     -   (5R,8S)-3-(2,6-difluorophenyl)-9,9-dimethyl-8-(pyridin-2-yl)-5,6,7,8-tetrahydro-5,8-methanocinnoline;     -   (5R,8S)-3-(2,6-difluorophenyl)-9,9-dimethyl-8-(pyridin-3-yl)-5,6,7,8-tetrahydro-5,8-methanocinnoline     -   (5R,8S)-3-(2,6-difluorophenyl)-9,9-dimethyl-8-(pyrazin-2-yl)-5,6,7,8-tetrahydro-5,8-methanocinnoline;         or         6-((5R,8S)-3-(2,6-difluorophenyl)-9,9-dimethyl-5,6,7,8-tetrahydro-5,8-methanocinnolin-8-yl)-1-methylpyridin-2(1H)-one.

The invention also provides and pharmaceutical compositions comprising the compounds, methods of using the compounds, and methods of preparing the compounds.

DETAILED DESCRIPTION OF THE INVENTION

Definitions

Unless otherwise stated, the following terms used in this Application, including the specification and claims, have the definitions given below. It must be noted that, as used in the specification and the appended claims, the singular forms “a”, “an,” and “the” include plural referents unless the context clearly dictates otherwise. In some instances dashes (“-”) may be used interchangeably within definitions (for example, “alkoxyalkyl” omits the dash found in the equivalent term “alkoxy-alkyl”).

“Alkyl” means the monovalent linear or branched saturated hydrocarbon moiety, consisting solely of carbon and hydrogen atoms, having from one to twelve carbon atoms. “Lower alkyl” refers to an alkyl group of one to six carbon atoms, i.e. C₁-C₆alkyl. Examples of alkyl groups include, but are not limited to, methyl, ethyl, propyl, isopropyl, isobutyl, sec-butyl, tert-butyl, pentyl, n-hexyl, octyl, dodecyl, and the like.

“Alkenyl” means a linear monovalent hydrocarbon radical of two to six carbon atoms or a branched monovalent hydrocarbon radical of three to six carbon atoms, containing at least one double bond, e.g., ethenyl, propenyl, and the like.

“Alkynyl” means a linear monovalent hydrocarbon radical of two to six carbon atoms or a branched monovalent hydrocarbon radical of three to six carbon atoms, containing at least one triple bond, e.g., ethynyl, propynyl, and the like.

“Alkylene” means a linear saturated divalent hydrocarbon radical of one to six carbon atoms or a branched saturated divalent hydrocarbon radical of three to six carbon atoms, e.g., methylene, ethylene, 2,2-dimethylethylene, propylene, 2-methylpropylene, butylene, pentylene, and the like.

“Alkoxy” and “alkyloxy”, which may be used interchangeably, mean a moiety of the formula —OR, wherein R is an alkyl moiety as defined herein. Examples of alkoxy moieties include, but are not limited to, methoxy, ethoxy, isopropoxy, and the like.

“Alkoxyalkyl” means a moiety of the formula R^(a)—O—R^(b)—, where R^(a) is alkyl and R^(b) is alkylene as defined herein. Exemplary alkoxyalkyl groups include, by way of example, 2-methoxyethyl, 3-methoxypropyl, 1-methyl-2-methoxyethyl, 1-(2-methoxyethyl)-3-methoxypropyl, and 1-(2-methoxyethyl)-3-methoxypropyl.

“Alkoxyalkoxy” means a group of the formula —O—R—R′ wherein R is alkylene and R′ is alkoxy as defined herein.

“Alkylcarbonyl” means a moiety of the formula —C(O)—R, wherein R is alkyl as defined herein.

“Alkoxycarbonyl” means a group of the formula —C(O)—R wherein R is alkoxy as defined herein.

“Alkylcarbonylamino” means a group of the formula —R—C(O)—NR′— wherein R is alkyl and R′ is hydrogen or alkyl.

“Alkylcarbonylalkyl” means a group of the formula —R—C(O)—R′ wherein R is alkylene and R′ is alkyl as defined herein.

“Alkoxyalkylcarbonyl” means a moiety of the formula —C(O)—R—R′, wherein R is alkylene and R′ is alkoxy as defined herein.

“Alkoxycarbonylalkyl” means a group of the formula —R—C(O)—R wherein R is alkylene and R′ is alkoxy as defined herein.

“Alkoxycarbonylamino” means a moiety of the formula R—C(O)—NR′—, wherein R is alkoxy and R′ is hydrogen or alkyl as defined herein.

“Alkoxycarbonylaminoalkyl” means a moiety of the formula R—C(O)—NR′—R″—, wherein R is alkoxy, R′ is hydrogen or alkyl, and R″ is alkylene as defined herein.

“Alkoxycarbonylalkoxy” means a group of the formula —O—R—C(O)—R′ wherein R is alkylene and R′ is alkoxy as defined herein.

“Hydroxycarbonylalkoxy” means a group of the formula —O—R—C(O)—OH wherein R is alkylene as defined herein.

“Alkylaminocarbonylalkoxy” means a group of the formula —O—R—C(O)—NHR′ wherein R is alkylene and R′ is alkyl as defined herein.

“Dialkylaminocarbonylalkoxy” means a group of the formula —O—R—C(O)—NR′R″ wherein R is alkylene and R′ and R″ are alkyl as defined herein.

“Alkylaminoalkoxy” means a group of the formula —O—R—NHR′ wherein R is alkylene and R′ is alkyl as defined herein.

“Dialkylaminoalkoxy” means a group of the formula —O—R—NR′R′ wherein R is alkylene and R′ and R″ are alkyl as defined herein.

“Alkylsulfonyl” means a moiety of the formula —SO₂—R, wherein R is alkyl as defined herein.

“Alkylsulfonylalkyl means a moiety of the formula —R′—SO₂—R″ where R′ is alkylene and R″ is alkyl as defined herein.

“Alkylsulfonylalkoxy” means a group of the formula —O—R—SO₂—R′ wherein R is alkylene and R′ is alkyl as defined herein.

“Amino means a moiety of the formula —NRR′ wherein R and R′ each independently is hydrogen or alkyl as defined herein. “Amino thus includes “alkylamino (where one of R and R′ is alkyl and the other is hydrogen) and “dialkylamino (where R and R′ are both alkyl.

“Aminocarbonyl” means a group of the formula —C(O)—R wherein R is amino as defined herein.

“N-hydroxy-aminocarbonyl” means a group of the formula —C(O)—NR—OH wherein R is hydrogen or alkyl as defined herein.

“N-alkoxy-aminocarbonyl” means a group of the formula —C(O)—NR—R′ wherein R is hydrogen or alkyl and R′ is alkoxy as defined herein.

“Aminocarbonylaminoalkyl” means a group of the formula R₂N—C(O)—NR′—R″— wherein each R is independently hydrogen or alkyl, R′ is hydrogen or alkyl, and R″ is alkylene as defined herein.

“N-alkyl-aminocarbonyl means a group of the formula —C(O)—NH—R wherein R is alkyl as defined herein.

“N-hydroxy-N-alkylaminocarbonyl means a group of the formula —C(O)—NRR′ wherein R is alkyl as defined herein and R′ is hydroxy.

“N-alkoxy-N-alkylaminocarbonyl” means a group of the formula —C(O)—NRR′ wherein R is alkyl and R′ is alkoxy as defined herein.

“N,N-di-C₁₋₆alkyl-aminocarbonyl” means a group of the formula —C(O)—NRR′ wherein R and R′ are alkyl as defined herein.

“Aminosulfonyl” means a group of the formula —SO₂—NH₂.

“N-alkylaminosulfonyl” means a group of the formula —SO₂—NHR wherein R is alkyl as defined herein.

“N,N-dialkylaminosulfonyl” means a group of the formula —SO₂—NRR′ wherein R and R′ are alkyl as defined herein.

“Alkylsulfonylamino” means a group of the formula —NR′—SO₂—R wherein R id alkyl and R′ is hydrogen or alkyl as defined herein.

“N-(alkylsulfonyl)-aminoalkyl” means a group of the formula —R—NH—SO₂—R′ wherein R is alkylene and R′ is alkyl as defined herein.

“N-(Alkylsulfonyl)aminocarbonyl” means a group of the formula —C(O)—NH—SO₂—R wherein wherein R is alkyl as defined herein.

“N-(Alkylsulfonyl)-N-alkylaminocarbonyl” means a group of the formula —C(O)—NR—SO₂—R′ wherein R and R′ are alkyl as defined herein.

“N-Alkoxyalkyl-aminocarbonyl” means a group of the formula —C(O)—NR—R′—OR″ wherein R is hydrogen or alkyl, R′ is alkylene, and R″ is alkyl as defined herein.

“N-Hydroxyalkyl-aminocarbonyl” means a group of the formula —C(O)—NR—R′—OH″ wherein R is hydrogen or alkyl and R′ is alkylene as defined herein.

“Alkoxyamino” means a moiety of the formula —NR—OR′ wherein R is hydrogen or alkyl and R′ is alkyl as defined herein.

“Alkylsulfanyl” means a moiety of the formula —SR wherein R is alkyl as defined herein.

“Aminoalkyl” means a group —R—R′ wherein R′ is amino and R is alkylene as defined herein.

“Aminoalkyl” includes aminomethyl, aminoethyl, 1-aminopropyl, 2-aminopropyl, and the like.

The amino moiety of “aminoalkyl” may be substituted once or twice with alkyl to provide “alkylaminoalkyl” and “dialkylaminoalkyl” respectively. “Alkylaminoalkyl” includes methylaminomethyl, methylaminoethyl, methylaminopropyl, ethylaminoethyl and the like. “Dialkylaminoalkyl” includes dimethylaminomethyl, dimethylaminoethyl, dimethylaminopropyl, N-methyl-N-ethylaminoethyl, and the like.

“Aminoalkoxy” means a group —OR—R′ wherein R′ is amino and R is alkylene as defined herein.

“Alkylsulfonylamido” means a moiety of the formula —NR′SO₂—R wherein R is alkyl and R′ is hydrogen or alkyl.

“Aminocarbonyloxyalkyl” or “carbamylalkyl” means a group of the formula —R—O—C(O)—NR′R″ wherein R is alkylene and R′, R″ each independently is hydrogen or alkyl as defined herein.

“Alkynylalkoxy” means a group of the formula —O—R—R′ wherein R is alkylene and R′ is alkynyl as defined herein.

“Aryl” means a monovalent cyclic aromatic hydrocarbon moiety consisting of a mono-, bi- or tricyclic aromatic ring. The aryl group can be optionally substituted as defined herein. Examples of aryl moieties include, but are not limited to, phenyl, naphthyl, phenanthryl, fluorenyl, indenyl, pentalenyl, azulenyl, oxydiphenyl, biphenyl, methylenediphenyl, aminodiphenyl, diphenylsulfidyl, diphenylsulfonyl, diphenylisopropylidenyl, benzodioxanyl, benzofuranyl, benzodioxylyl, benzopyranyl, benzoxazinyl, benzoxazinonyl, benzopiperadinyl, benzopiperazinyl, benzopyrrolidinyl, benzomorpholinyl, methylenedioxyphenyl, ethylenedioxyphenyl, and the like, of which may be optionally substituted as defined herein.

“Arylalkyl” and “Aralkyl”, which may be used interchangeably, mean a radical-R^(a)R^(b) where R^(a) is an alkylene group and R^(b) is an aryl group as defined herein; e.g., phenylalkyls such as benzyl, phenylethyl, 3-(3-chlorophenyl)-2-methylpentyl, and the like are examples of arylalkyl.

“Arylsulfonyl means a group of the formula —SO₂—R wherein R is aryl as defined herein.

“Aryloxy” means a group of the formula —O—R wherein R is aryl as defined herein.

“Aralkyloxy” means a group of the formula —O—R—R″ wherein R is alkylene and R′ is aryl as defined herein.

“Carboxy” or “hydroxycarbonyl”, which may be used interchangeably, means a group of the formula —C(O)—OH.

“Cyanoalkyl” “means a moiety of the formula —R′—R″, where R′ is alkylene as defined herein and R″ is cyano or nitrile.

“Cycloalkyl” means a monovalent saturated carbocyclic moiety consisting of mono- or bicyclic rings. Particular cycloalkyl are unsubstituted or substituted with alkyl. Cycloalkyl can optionally be substituted as defined herein. Unless defined otherwise, cycloalkyl may be optionally substituted with one or more substituents, wherein each substituent is independently hydroxy, alkyl, alkoxy, halo, haloalkyl, amino, monoalkylamino, or dialkylamino. Examples of cycloalkyl moieties include, but are not limited to, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, and the like, including partially unsaturated (cycloalkenyl) derivatives thereof.

“Cycloalkenyl” means a cycloalkyl as defined herein that includes at least one double bond or unsaturation. Exemplary cycloalkenyl include cyclohexenyl, cyclopentenyl, cyclobutenyl and the like.

“Cycloalkylalkyl” means a moiety of the formula —R′—R″, where R′ is alkylene and R″ is cycloalkyl as defined herein.

“Cycloalkylalkoxy” means a group of the formula —O—R—R′ wherein R is alkylene and R′ is cycloalkyl as defined herein.

“Cycloalkylcarbonyl” means a moiety of the formula —C(O)—R, wherein R is cycloalkyl as defined herein.

“C₃₋₆cycloalkyl-C₁₋₆alkyl-carbonyl” means a moiety of the formula —C(O)—R, wherein R is cycloalkylalkyl as defined herein.

“Cyanoalkylcarbonyl” means a moiety of the formula —C(O)—R—R′, wherein R is alkylene as defined herein and R′ is cyano or nitrile.

“N-Cyano-aminocarbonyl” means a moiety of the formula —C(O)—NHR, wherein R is cyano or nitrile.

“N-Cyano-N-alkyl-aminocarbonyl” means a moiety of the formula —C(O)—NRR′—R, wherein R′ is alkyl as defined herein and R is cyano or nitrile.

“Cycloalkylsulfonyl” means a group of the formula —SO₂—R wherein R is cycloalkyl as defined herein.

“Cycloalkylalkylsulfonyl” means a group of the formula —SO₂—R wherein R is cycloalkylalkyl as defined herein.

“Formyl” means a moiety of the formula —C(O)—H.

“Heteroaryl” means a monocyclic or bicyclic radical of 5 to 12 ring atoms having at least one aromatic ring containing one, two, or three ring heteroatoms selected from N, O, or S, the remaining ring atoms being C, with the understanding that the attachment point of the heteroaryl radical will be on an aromatic ring. The heteroaryl ring may be optionally substituted as defined herein. Examples of heteroaryl moieties include, but are not limited to, optionally substituted imidazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, oxadiazolyl, thiadiazolyl, pyrazinyl, thienyl, benzothienyl, thiophenyl, furanyl, pyranyl, pyridyl, pyrrolyl, pyrazolyl, pyrimidyl, quinolinyl, isoquinolinyl, benzofuryl, benzothiophenyl, benzothiopyranyl, benzimidazolyl, benzooxazolyl, benzooxadiazolyl, benzothiazolyl, benzothiadiazolyl, benzopyranyl, indolyl, isoindolyl, triazolyl, triazinyl, quinoxalinyl, purinyl, quinazolinyl, quinolizinyl, naphthyridinyl, pteridinyl, carbazolyl, azepinyl, diazepinyl, acridinyl and the like, each of which may be optionally substituted as defined herein.

Heteroarylalkyl” or “heteroaralkyl” means a group of the formula —R—R′ wherein R is alkylene and R′ is heteroaryl as defined herein.

“Heteroarylsulfonyl means a group of the formula —SO₂—R wherein R is heteroaryl as defined herein.

“Heteroaryloxy” means a group of the formula —O—R wherein R is heteroaryl as defined herein.

“Heteroaralkyloxy” means a group of the formula —O—R—R″ wherein R is alkylene and R′ is heteroaryl as defined herein.

The terms “halo”, “halogen” and “halide”, which may be used interchangeably, refer to a substituent fluoro, chloro, bromo, or iodo.

“Haloalkyl” means alkyl as defined herein in which one or more hydrogen has been replaced with same or different halogen. Exemplary haloalkyls include —CH₂Cl, —CH₂CF₃, —CH₂CCl₃, perfluoroalkyl (e.g., —CF₃), and the like.

“Haloalkoxy” means a moiety of the formula —OR, wherein R is a haloalkyl moiety as defined herein. An exemplary haloalkoxy is difluoromethoxy.

“Heterocycloamino” means a saturated ring wherein at least one ring atom is N, NH or N-alkyl and the remaining ring atoms form an alkylene group.

“Heterocyclyl” means a monovalent saturated moiety, consisting of one to three rings, incorporating one, two, or three or four heteroatoms (chosen from nitrogen, oxygen or sulfur). The heterocyclyl ring may be optionally substituted as defined herein. Examples of heterocyclyl moieties include, but are not limited to, optionally substituted piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, azepinyl, pyrrolidinyl, azetidinyl, tetrahydropyranyl, tetrahydrofuranyl, oxetanyl and the like. Such heterocyclyl may be optionally substituted as defined herein.

“Heterocyclylalkyl” means a moiety of the formula —R—R′ wherein R is alkylene and R′ is heterocyclyl as defined herein.

“Heterocyclyloxy” means a moiety of the formula —OR wherein R is heterocyclyl as defined herein.

“Heterocyclylalkoxy” means a moiety of the formula —OR—R′ wherein R is alkylene and R′ is heterocyclyl as defined herein.

“Hydroxyalkoxy” means a moiety of the formula —OR wherein R is hydroxyalkyl as defined herein.

“Hydroxyalkylamino” means a moiety of the formula —NR—R′ wherein R is hydrogen or alkyl and R′ is hydroxyalkyl as defined herein.

“Hydroxyalkylaminoalkyl” means a moiety of the formula —R—NR′—R″ wherein R is alkylene, R′ is hydrogen or alkyl, and R″ is hydroxyalkyl as defined herein.

“Hydroxycarbonylalkyl” or “carboxyalkyl” means a group of the formula —R—(CO)—OH where R is alkylene as defined herein.

“Hydroxycarbonylalkoxy” means a group of the formula —O—R—C(O)—OH wherein R is alkylene as defined herein.

“Hydroxyalkylcarbonyl” means a moiety of the formula —C(O)—R—R′, wherein R is alkylene as defined herein and R′ is hydroxy.

“Hydroxyalkyloxycarbonylalkyl” or “hydroxyalkoxycarbonylalkyl” means a group of the formula —R—C(O)—O—R—OH wherein each R is alkylene and may be the same or different.

“Hydroxyalkyl” means an alkyl moiety as defined herein, substituted with one or more, for example, one, two or three hydroxy groups, provided that the same carbon atom does not carry more than one hydroxy group. Representative examples include, but are not limited to, hydroxymethyl, 2-hydroxyethyl, 2-hydroxypropyl, 3-hydroxypropyl, 1-(hydroxymethyl)-2-methylpropyl, 2-hydroxybutyl, 3-hydroxybutyl, 4-hydroxybutyl, 2,3-dihydroxypropyl, 2-hydroxy-1-hydroxymethylethyl, 2,3-dihydroxybutyl, 3,4-dihydroxybutyl and 2-(hydroxymethyl)-3-hydroxypropyl

“Hydroxycycloalkyl” means a cycloalkyl moiety as defined herein wherein one, two or three hydrogen atoms in the cycloalkyl radical have been replaced with a hydroxy substituent. Representative examples include, but are not limited to, 2-, 3-, or 4-hydroxycyclohexyl, and the like.

“Oxo” means a group of the formula ═O (i.e., an oxygen with a double bond). Thus, for example, a 1-oxo-ethyl group is an acetyl group.

“Alkoxy hydroxyalkyl” and “hydroxy alkoxyalkyl”, which may be used interchangeably, means an alkyl as defined herein that is substituted at least once with hydroxy and at least once with alkoxy.

“Alkoxy hydroxyalkyl” and “hydroxy alkoxyalkyl” thus encompass, for example, 2-hydroxy-3-methoxy-propan-1-yl and the like.

“Urea” or “ureido” means a group of the formula —NR′—C(O)—NR″R″ wherein R′, R″ and R′″ each independently is hydrogen or alkyl.

“Carbamate” means a group of the formula —O—C(O)—NR′R″ wherein R′ and R″ each independently is hydrogen or alkyl.

“Carboxy” means a group of the formula —O—C(O)—OH.

“Sulfonamido” means a group of the formula —SO₂—NR′R″ wherein R′, R″ and R′″ each independently is hydrogen or alkyl.

“Optionally substituted” when used in association with an “aryl”, phenyl″, “heteroaryl” “cycloalkyl” or “heterocyclyl” moiety means that such moiety may be unsubstituted (i.e., all open valencies are occupied by a hydrogen atom) or substituted with specific groups as related herein.

“Leaving group” means the group with the meaning conventionally associated with it in synthetic organic chemistry, i.e., an atom or group displaceable under substitution reaction conditions. Examples of leaving groups include, but are not limited to, halogen, alkane- or arylenesulfonyloxy, such as methanesulfonyloxy, ethanesulfonyloxy, thiomethyl, benzenesulfonyloxy, tosyloxy, and thienyloxy, dihalophosphinoyloxy, optionally substituted benzyloxy, isopropyloxy, acyloxy, and the like.

“Modulator” means a molecule that interacts with a target. The interactions include, but are not limited to, agonist, antagonist, and the like, as defined herein.

“Optional” or “optionally” means that the subsequently described event or circumstance may but need not occur, and that the description includes instances where the event or circumstance occurs and instances in which it does not.

“Disease” and “Disease state” means any disease, condition, symptom, disorder or indication.

“Inert organic solvent” or “inert solvent” means the solvent is inert under the conditions of the reaction being described in conjunction therewith, including for example, benzene, toluene, acetonitrile, tetrahydrofuran, N,N-dimethylformamide, chloroform, methylene chloride or dichloromethane, dichloroethane, diethyl ether, ethyl acetate, acetone, methyl ethyl ketone, methanol, ethanol, propanol, isopropanol, tert-butanol, dioxane, pyridine, and the like. Unless specified to the contrary, the solvents used in the reactions of the present invention are inert solvents.

“Pharmaceutically acceptable” means that which is useful in preparing a pharmaceutical composition that is generally safe, non-toxic, and neither biologically nor otherwise undesirable and includes that which is acceptable for veterinary as well as human pharmaceutical use.

“Pharmaceutically acceptable salts” of a compound means salts that are pharmaceutically acceptable, as defined herein, and that possess the desired pharmacological activity of the parent compound.

It should be understood that all references to pharmaceutically acceptable salts include solvent addition forms (solvates) or crystal forms (polymorphs) as defined herein, of the same acid addition salt.

“Protective group” or “protecting group” means the group which selectively blocks one reactive site in a multifunctional compound such that a chemical reaction can be carried out selectively at another unprotected reactive site in the meaning conventionally associated with it in synthetic chemistry. Certain processes of this invention rely upon the protective groups to block reactive nitrogen and/or oxygen atoms present in the reactants. For example, the terms “amino-protecting group” and “nitrogen protecting group” are used interchangeably herein and refer to those organic groups intended to protect the nitrogen atom against undesirable reactions during synthetic procedures. Exemplary nitrogen protecting groups include, but are not limited to, trifluoroacetyl, acetamido, benzyl (Bn), benzyloxycarbonyl (carbobenzyloxy, CBZ), p-methoxybenzyloxycarbonyl, p-nitrobenzyloxycarbonyl, tert-butoxycarbonyl (BOC), and the like. The artisan in the art will know how to chose a group for the ease of removal and for the ability to withstand the following reactions.

“Solvates” means solvent additions forms that contain either stoichiometric or non stoichiometric amounts of solvent. Some compounds have a tendency to trap a fixed molar ratio of solvent molecules in the crystalline solid state, thus forming a solvate. If the solvent is water the solvate formed is a hydrate, when the solvent is alcohol, the solvate formed is an alcoholate. Hydrates are formed by the combination of one or more molecules of water with one of the substances in which the water retains its molecular state as H₂O, such combination being able to form one or more hydrate.

“Arthritis” means a disease or condition that causes damage to joints of the body and pain associated with such joint damage. Arthritis includes rheumatoid arthritis, osteoarthritis, psoriatic arthritis, septic arthritis, spondyloarthropathies, gouty arthritis, systemic lupus erythematosus and juvenile arthritis, osteoarthritis, and other arthritic conditions.

“Respiratory disorder” refers to, without limitation, chronic obstructive pulmonary disease (COPD), asthma, bronchospasm, and the like.

“Subject” means mammals and non-mammals. Mammals means any member of the mammalia class including, but not limited to, humans; non-human primates such as chimpanzees and other apes and monkey species; farm animals such as cattle, horses, sheep, goats, and swine; domestic animals such as rabbits, dogs, and cats; laboratory animals including rodents, such as rats, mice, and guinea pigs; and the like. Examples of non-mammals include, but are not limited to, birds, and the like. The term “subject” does not denote a particular age or sex.

“Therapeutically effective amount” means an amount of a compound that, when administered to a subject for treating a disease state, is sufficient to effect such treatment for the disease state. The “therapeutically effective amount” will vary depending on the compound, disease state being treated, the severity or the disease treated, the age and relative health of the subject, the route and form of administration, the judgment of the attending medical or veterinary practitioner, and other factors.

The terms “those defined above” and “those defined herein” when referring to a variable incorporates by reference the broad definition of the variable as well as particular definitions, if any.

“Treating” or “treatment” of a disease state includes, inter alia, inhibiting the disease state, i.e., arresting the development of the disease state or its clinical symptoms, and/or relieving the disease state, i.e., causing temporary or permanent regression of the disease state or its clinical symptoms.

The terms “treating”, “contacting” and “reacting” when referring to a chemical reaction means adding or mixing two or more reagents under appropriate conditions to produce the indicated and/or the desired product. It should be appreciated that the reaction which produces the indicated and/or the desired product may not necessarily result directly from the combination of two reagents which were initially added, i.e., there may be one or more intermediates which are produced in the mixture which ultimately leads to the formation of the indicated and/or the desired product.

Nomenclature and Structures

In general, the nomenclature and chemical names used in this Application are based on ChembioOffice™ by CambridgeSoft™. Any open valency appearing on a carbon, oxygen sulfur or nitrogen atom in the structures herein indicates the presence of a hydrogen atom unless indicated otherwise. Where a nitrogen-containing heteroaryl ring is shown with an open valency on a nitrogen atom, and variables such as R^(a), R^(b) or R^(c) are shown on the heteroaryl ring, such variables may be bound or joined to the open valency nitrogen. Where a chiral center exists in a structure but no specific stereochemistry is shown for the chiral center, both enantiomers associated with the chiral center are encompassed by the structure. Where a structure shown herein may exist in multiple tautomeric forms, all such tautomers are encompassed by the structure. The atoms represented in the structures herein are intended to encompass all naturally occurring isotopes of such atoms. Thus, for example, the hydrogen atoms represented herein are meant to include deuterium and tritium, and the carbon atoms are meant to include C¹³ and C¹⁴ isotopes. One or more carbon atom(s) of a compound of the invention may be replaced by a silicon atom(s), and it is contemplated that one or more oxygen atom(s) of a compound of the invention may be replaced by a sulfur or selenium atom(s).

Compounds of the Invention

The invention provides compounds of formula I:

or pharmaceutical salts thereof, wherein:

-   A is:     -   a six membered hetereoaryl selected from: pyridinyl;         pyrimidinyl; pyrazinyl; pyridazinyl; and triazinyl; -   m is: 0; 1; or 2; -   n is: 0; or 1; -   R¹ is:     -   halo; -   R² is:     -   hydrogen; or     -   halo; -   R³ is:     -   hydrogen;     -   C₁₋₆alkyl; or     -   halo; -   R⁴ is:     -   C₁₋₆alkyl;     -   oxo;     -   hydroxy;     -   C₁₋₆alkyoxy;     -   C₁₋₆alkyoxycarbonyl;     -   halo-C₁₋₆alkyl;     -   cyano; or     -   halo; -   R⁵ is:     -   heteroaryl selected from pyridinyl, pyrimidinyl, pyrazinyl,         pyridazinyl, oxadiazolyl, triazolyl, oxazolyl, tetrazolyl,         imidazolyl, pyrazolyl, isoxazolyl, thiazolyl, isothiazolyl and         thiadiazolyl, each of which may be unsubstituted or substituted         once or twice with R^(a);     -   heterocyclyl selected from azetidinyl, oxetanyl, pyrrolidinyl,         imidazolidinyl, morpholinyl, 1-oxa-6-azaspiro[3.3]heptanyl,         piperazinyl, piperidinyl, pyrrolidinyl, imidazolinidinyl,         tetrahydropyranyl, tetrahydrofuranyl, tetrahydrotriazinyl,         thiomorpolinyl, 1,1-dioxo-thiomorpholinyl, and dihydropyridinyl,         each of which may be unsubstituted or substituted once or twice         with R^(a);     -   cyano;     -   —NR^(b)R^(c);     -   —C₁₋₆alkylene-NR^(b)R^(c);     -   —OR^(d);     -   —C(O)NR^(e)R^(f);     -   —SO₂NR^(e)R^(f);     -   —C(O)OR′; or     -   hydroxy-C₁₋₆alkyl; -   R^(a) is:     -   C₁₋₆alkyl;     -   C₁₋₆alkenyl;     -   C₁₋₆alkynyl;     -   amino;     -   cyano;     -   cyano-C₁₋₆alkyl;     -   hydroxy;     -   oxo;     -   halo;     -   halo-C₁₋₆alkyl;     -   hydroxy-C₁₋₆alkyl;     -   hydroxy-C₁₋₆alkoxy;     -   hydroxy-C₁₋₆alkyl substituted with halo;     -   hydroxy-C₁₋₆alkoxy substituted with halo;     -   aminocarbonyl;     -   aminocarbonyl-C₁₋₆alkyl;     -   aminocarbonyl-C₁₋₆alkoxy;     -   hydroxy-C₁₋₆alkylaminocarbonyl;     -   C₁₋₆alkylcarbonyl;     -   hydroxy-C₁₋₆alkylcarbonyl;     -   C₃₋₆cycloalkyl which may be unsubstituted or substituted once         with R^(h);     -   C₁₋₆alkyoxycarbonyl;     -   C₁₋₆alkylsulfonyl;     -   C₁₋₆alkylsulfonyl-C₁₋₆alkyl;     -   C₃₋₆cycloalkylsulfonyl;     -   C₃₋₆cycloalkylsulfonyl-C₁₋₆alkyl;     -   C₃₋₆cycloalkyl-C₁₋₆alkylsulfonyl;     -   C₃₋₆cycloalkyl-C₁₋₆alkylsulfonyl-C₁₋₆alkyl;     -   oxetanyl which may be unsubstituted or substituted once with         R^(h); -   R^(b) is:     -   hydrogen; or     -   C₁₋₆alkyl; -   R^(c) is:     -   hydrogen;     -   C₁₋₆alkyl;     -   halo-C₁₋₆alkyl;     -   cyano-C₁₋₆alkyl;     -   C₁₋₆alkylcarbonyl;     -   hydroxy-C₁₋₆alkylcarbonyl;     -   oxetanylcarbonyl;     -   oxetanylsulfonyl;     -   C₁₋₆alkylsulfonyl;     -   C₁₋₆alkylsulfonyl-C₁₋₆alkyl;     -   hydroxyl-C₁₋₆alkyl;     -   C₁₋₆alkyoxy-C₁₋₆alkyl;     -   C₃₋₆cycloalkyl which may be unsubstituted or substituted once         with R^(h);     -   C₃₋₆cycloalkyl-C₁₋₆alkyl wherein the C₃₋₆cycloalkyl may be         unsubstituted or substituted once with R^(h);     -   heterocyclyl selected from oxetanyl, azetidinyl, morpholinyl and         tetrahydrofuranyl, each of which may be unsubstituted or         substituted once or twice with R^(h);     -   heterocyclyl-C₁₋₆alkyl wherein the heterocyclyl is selected from         oxetanyl and azetidinyl, each of which may be unsubstituted or         substituted once with R^(h);     -   heteroaryl selected from pyrazinyl and triazolyl, each of which         may be unsubstituted or substituted once or twice with R^(h); or     -   heteroaryl-C₁₋₆alkyl wherein the heteroaryl is selected from         pyrazinyl and triazolyl, each of which may be unsubstituted or         substituted once or twice with R^(h);     -   or R^(b) and R^(c) together with the nitrogen atom to which they         are attached may form heterocyclyl selected from azetidinyl,         pyrrolidinyl, piperidinyl, piperazinyl, azepinyl, morpholinyl,         thiomorpholinyl, and 1,1-dioxothiomorpholinyl, each of which         heterocylcles may be unsubstituted or substituted once with         R^(h); -   R^(d) is:     -   C₁₋₆alkyl;     -   hydroxy-C₁₋₆alkyl;     -   C₁₋₆alkyoxy-C₁₋₆alkyl;     -   aminocarbonyl-C₁₋₆alkyl; or     -   heteroaryl selected from pyridinyl, pyrimidinyl and pyrazinyl; -   R^(e) is:     -   hydrogen;     -   C₁₋₆alkyl; or     -   hydroxy-C₁₋₆alkyl; -   R^(f) is:     -   hydrogen;     -   C₁₋₆alkyl;     -   halo-C₁₋₆alkyl;     -   cyano-C₁₋₆alkyl;     -   hydroxyl-C₁₋₆alkyl;     -   C₁₋₆alkyoxy;     -   C₁₋₆alkyoxy-C₁₋₆alkyl;     -   C₁₋₆alkylsulfonyl-C₁₋₆alkyl;     -   C₃₋₆cycloalkyl which may be unsubstituted or substituted once         with R^(h);     -   C₃₋₆cycloalkyl-C₁₋₆alkyl wherein the C₃₋₆cycloalkyl may be         unsubstituted or substituted once with R^(h);     -   heterocyclyl selected from oxetanyl, azetidinyl, morpholinyl and         tetrahydrofuranyl, each of which may be unsubstituted or         substituted once or twice with R^(h);     -   heterocyclyl-C₁₋₆alkyl wherein the heterocyclyl is selected from         oxetanyl and azetidinyl, each of which may be unsubstituted or         substituted once with R^(h);     -   heteroaryl selected from pyrazinyl and triazolyl, each of which         may be unsubstituted or substituted once or twice with R^(h); or     -   heteroaryl-C₁₋₆alkyl wherein the heteroaryl is selected from         pyrazinyl and triazolyl, each of which may be unsubstituted or         substituted once or twice with R^(h);     -   or R^(e) and R^(f) together with the nitrogen atom to which they         are attached may form heterocyclyl selected from azetidinyl,         pyrrolidinyl, piperidinyl, piperazinyl, azepinyl, morpholinyl,         thiomorpholinyl, and 1,1-dioxothiomorpholinyl, each of which         heterocylcles may be unsubstituted or substituted once with         R^(h); -   R^(g) is:     -   hydrogen; or     -   C₁₋₆alkyl; -   R^(h) is:     -   C₁₋₆alkyl;     -   cyano;     -   hydroxy;     -   aminocarbonyl;     -   oxo; or     -   hydroxy-C₁₋₆alkyl;     -   provided that the compound is not:     -   (5R,8S)-3-(2,6-difluorophenyl)-9,9-dimethyl-8-(pyridin-2-yl)-5,6,7,8-tetrahydro-5,8-methanocinnoline;     -   (5R,8S)-3-(2,6-difluorophenyl)-9,9-dimethyl-8-(pyridin-3-yl)-5,6,7,8-tetrahydro-5,8-methanocinnoline     -   (5R,8S)-3-(2,6-difluorophenyl)-9,9-dimethyl-8-(pyrazin-2-yl)-5,6,7,8-tetrahydro-5,8-methanocinnoline;         or     -   6-((5R,8S)-3-(2,6-difluorophenyl)-9,9-dimethyl-5,6,7,8-tetrahydro-5,8-methanocinnolin-8-yl)-1-methylpyridin-2(1H)-one.

In certain embodiments, it is provisioned that that ring A together with R⁴ and R⁵ do not form pyrimidin-2, pyrimidin-3-yl pyrazin-2-yl or 1-methylpyridin-2-(1H)-one-5-yl.

In certain embodiments, it is provisioned that when A is pyrimidin-2-yl, pyrimidin-3-yl or pyrazin-2-yl, then m and n are not 0, and further that when A is pyrimidin-2-yl, then R⁴ is not methyl at the one position or oxo at the two or five position;

In certain embodiments, m is 0.

In certain embodiments, m is 1.

In certain embodiments, m is 2.

In certain embodiments, m is 0 or 1.

In certain embodiments, n is 0.

In certain embodiments, n is 1.

In certain embodiments, A is a six membered hetereoaryl selected from: pyridinyl; pyrimidinyl; pyrazinyl; and pyridazinyl.

In certain embodiments, A is a six membered hetereoaryl selected from: pyridinyl; pyrimidinyl; and pyrazinyl.

In certain embodiments, A is pyridinyl.

In certain embodiments, A is pyrimidinyl.

In certain embodiments, A is pyrazinyl.

In certain embodiments, A is pyridrazinyl.

In certain embodiments, R′ is fluoro.

In certain embodiments, R² is hydrogen.

In certain embodiments, R² is halo.

In certain embodiments, R² is fluoro.

In certain embodiments, R³ is hydrogen.

In certain embodiments, R³ is halo.

In certain embodiments, R³ is C₁₋₆alkyl.

In certain embodiments, R⁴ is: C₁₋₆alkyl; oxo; halo; or cyano.

In certain embodiments, R⁴ is C₁₋₆alkyl.

In certain embodiments, R⁴ is oxo.

In certain embodiments, R⁴ is hydroxyl.

In certain embodiments, R⁴ is C₁₋₆alkyoxy.

In certain embodiments, R⁴ is halo-C₁₋₆alkyl.

In certain embodiments, R⁴ is cyano.

In certain embodiments, R⁴ is halo.

In certain embodiments, R⁵ is:

-   -   heteroaryl selected from pyridinyl, pyrimidinyl, oxadiazolyl,         triazolyl, oxazolyl, tetrazolyl, imidazolyl, pyrazolyl, and         isoxazolyl, each of which may be unsubstituted or substituted         once or twice with R^(a);     -   heterocyclyl selected from azetidinyl, oxetanyl, pyrrolidinyl,         imidazolidinyl, morpholinyl, 1-oxa-6-azaspiro[3.3]heptanyl,         piperazinyl, piperidinyl, and dihydropyridinyl, each of which         may be unsubstituted or substituted once or twice with R^(a);     -   —NR^(b)R^(c);     -   —C(O)NR^(e)R^(f); or     -   -hydroxy-C₁₋₆alkyl.

In certain embodiments, R⁵ is heteroaryl selected from pyridinyl, pyrimidinyl, oxadiazolyl, triazolyl, oxazolyl, tetrazolyl, imidazolyl, pyrazolyl, and isoxazolyl, each of which may be unsubstituted or substituted once or twice with R^(a).

In certain embodiments, R⁵ is heteroaryl selected from pyridinyl, pyrimidinyl, oxadiazolyl, triazolyl, oxazolyl, tetrazolyl, imidazolyl, pyrazolyl, isoxazolyl, each of which may be unsubstituted or substituted once or twice with R^(a).

In certain embodiments, R⁵ is pyridinyl which may be unsubstituted or substituted once or twice with R^(a).

In certain embodiments, R⁵ is pyrimidinyl which may be unsubstituted or substituted once or twice with R^(a).

In certain embodiments, R⁵ is oxadiazolyl which may be unsubstituted or substituted once or twice with R^(a).

In certain embodiments, R⁵ is triazolyl which may be unsubstituted or substituted once or twice with R^(a).

In certain embodiments, R⁵ is oxazolyl which may be unsubstituted or substituted once or twice with R^(a).

In certain embodiments, R⁵ is tetrazolyl which may be unsubstituted or substituted once or twice with R^(a).

In certain embodiments, R⁵ is imidazolyl which may be unsubstituted or substituted once or twice with R^(a).

In certain embodiments, R⁵ is pyrazolyl which may be unsubstituted or substituted once or twice with R^(a).

In certain embodiments, R⁵ is isoxazolyl which may be unsubstituted or substituted once or twice with R^(a).

In certain embodiments, R⁵ is pyrazinyl which may be unsubstituted or substituted once or twice with R^(a).

In certain embodiments, R⁵ is pyridazinyl which may be unsubstituted or substituted once or twice with R^(a).

In certain embodiments, R⁵ is thiazolyl which may be unsubstituted or substituted once or twice with R^(a).

In certain embodiments, R⁵ is isothiazoly which may be unsubstituted or substituted once or twice with R^(a).

In certain embodiments, R⁵ is thiadiazolyl which may be unsubstituted or substituted once or twice with R^(a).

In certain embodiments, R⁵ is heterocyclyl selected from azetidinyl, oxetanyl, pyrrolidinyl, imidazolidinyl, morpholinyl, 1-oxa-6-azaspiro[3.3]heptanyl, piperazinyl, piperidinyl, and dihydropyridinyl, each of which may be unsubstituted or substituted once or twice with R^(a); In certain embodiments, R⁵ is heterocyclyl selected from azetidinyl, oxetanyl, pyrrolidinyl, imidazolidinyl, morpholinyl, 1-oxa-6-azaspiro[3.3]heptanyl, piperazinyl, piperidinyl, dihydropyridinyl, each of which may be unsubstituted or substituted once or twice with R^(a); In certain embodiments, R⁵ is azetidinyl which may be unsubstituted or substituted once with R^(a).

In certain embodiments, R⁵ is oxetanyl which may be unsubstituted or substituted once with R^(a).

In certain embodiments, R⁵ is pyrrolidinyl which may be unsubstituted or substituted once or twice with R^(a).

In certain embodiments, R⁵ is imidazolinidinyl which may be unsubstituted or substituted once or twice with R^(a).

In certain embodiments, R⁵ is mopholinyl which may be unsubstituted or substituted once or twice with R^(a).

In certain embodiments, R⁵ is 1-oxa-6-azaspiro[3.3]heptanyl, 0 which may be unsubstituted or substituted once or twice with R^(a).

In certain embodiments, R⁵ is piperazinyl, which may be unsubstituted or substituted once or twice with R^(a).

In certain embodiments, R⁵ is piperidinyl, which may be unsubstituted or substituted once or twice with R^(a).

In certain embodiments, R⁵ is dihydropyridinyl, which may be unsubstituted or substituted once or twice with R^(a).

In certain embodiments, R⁵ is pyrrolidinyl which may be unsubstituted or substituted once or twice with R^(a).

In certain embodiments, R⁵ is imidazolinidinyl which may be unsubstituted or substituted once or twice with R^(a).

In certain embodiments, R⁵ is tetrahydropyranyl which may be unsubstituted or substituted once or twice with R^(a).

In certain embodiments, R⁵ is tetrahydrofuranyl which may be unsubstituted or substituted once or twice with R^(a).

In certain embodiments, R⁵ is thiomorpolinyl which may be unsubstituted or substituted once or twice with R.

In certain embodiments, R⁵ is 1,1-dioxo-thiomorpholinyl which may be unsubstituted or substituted once or twice with R^(a).

In certain embodiments, R⁵ is cyano.

In certain embodiments, R⁵ is —NR^(b)R^(c).

In certain embodiments, R⁵ is —C₁₋₆alkylene-NR^(b)R^(c).

In certain embodiments, R⁵ is —CH_(z)NR^(b)R^(c).

In certain embodiments, R⁵ is —OR^(d).

In certain embodiments, R⁵ is —C(O)NR^(e)R^(f).

In certain embodiments, R⁵ is —SO_(z)NR^(e)R^(f).

In certain embodiments, R⁵ is —C(O)OR^(g).

In certain embodiments, R⁵ is hydroxy-C₁₋₆alkyl.

In certain embodiments, R^(a) is:

cyano-C₁₋₆alkyl;

halo-C₁₋₆alkyl;

hydroxy-C₁₋₆alkyl;

hydroxy-C₁₋₆alkoxy;

hydroxy-C₁₋₆alkyl substituted with halo; or

hydroxy-C₁₋₆alkoxy substituted with halo.

In certain embodiments, R^(a) is C₁₋₆alkyl;

In certain embodiments, R^(a) is C₁₋₆alkenyl;

In certain embodiments, R^(a) is C₁₋₆alkynyl;

In certain embodiments, R^(a) is amino.

In certain embodiments, R^(a) is cyano.

In certain embodiments, R^(a) is cyano-C₁₋₆alkyl.

In certain embodiments, R^(a) is amino.

In certain embodiments, R^(a) is hydroxy.

In certain embodiments, R^(a) is oxo.

In certain embodiments, R^(a) is halo.

In certain embodiments, R^(a) is halo-C₁₋₆alkyl.

In certain embodiments, R^(a) is hydroxy-C₁₋₆alkyl.

In certain embodiments, R^(a) is hydroxy-C₁₋₆alkoxy.

In certain embodiments, R^(a) is hydroxy-C₁₋₆alkyl substituted with halo.

In certain embodiments, R^(a) is hydroxy-C₁₋₆alkoxy substituted with halo.

In certain embodiments, R^(a) is aminocarbonyl.

In certain embodiments, R^(a) is aminocarbonyl-C₁₋₆alkyl.

In certain embodiments, R^(a) is aminocarbonyl-C₁₋₆alkoxy.

In certain embodiments, R^(a) is hydroxy-C₁₋₆alkylaminocarbonyl.

In certain embodiments, R^(a) is C₁₋₆alkylcarbonyl.

In certain embodiments, R^(a) is hydroxy-C₁₋₆alkylcarbonyl.

In certain embodiments, R^(a) is C₃₋₆cycloalkyl which may be unsubstituted or substituted once with R^(h).

In certain embodiments, R^(a) is C₁₋₆alkyoxycarbonyl.

In certain embodiments, R^(a) is C₁₋₆alkylsulfonyl.

In certain embodiments, R^(a) is C₁₋₆alkylsulfonyl-C₁₋₆alkyl.

In certain embodiments, R^(a) is C₃₋₆cycloalkylsulfonyl.

In certain embodiments, R^(a) is C₃₋₆cycloalkylsulfonyl-C₁₋₆alkyl.

In certain embodiments, R^(a) is C₃₋₆cycloalkyl-C₁₋₆alkylsulfonyl.

In certain embodiments, R^(a) is C₃₋₆cycloalkyl-C₁₋₆alkylsulfonyl-C₁₋₆alkyl.

In certain embodiments, R^(a) is oxetanyl which may be unsubstituted or substituted once with R^(h).

In certain embodiments, R^(b) is hydrogen.

In certain embodiments, R^(b) is C₁₋₆alkyl.

In certain embodiments, R^(c) is hydrogen.

In certain embodiments, R^(c) is C₁₋₆alkyl.

In certain embodiments, R^(c) is halo-C₁₋₆alkyl.

In certain embodiments, R^(c) is cyano-C₁₋₆alkyl.

In certain embodiments, R^(c) is C₁₋₆alkylcarbonyl.

In certain embodiments, R^(c) is hydroxy-C₁₋₆alkylcarbonyl.

In certain embodiments, R^(c) is oxetanylcarbonyl.

In certain embodiments, R^(c) is oxetanylsulfonyl.

In certain embodiments, R^(c) is C₁₋₆alkylsulfonyl.

In certain embodiments, R^(c) is C₁₋₆alkylsulfonyl-C₁₋₆alkyl.

In certain embodiments, R^(c) is hydroxyl-C₁₋₆alkyl.

In certain embodiments, R^(c) is C₁₋₆alkyoxy-C₁₋₆alkyl.

In certain embodiments, R^(c) is C₃₋₆cycloalkyl which may be unsubstituted or substituted once with R^(h).

In certain embodiments, R^(c) is C₃₋₆cycloalkyl-C₁₋₆alkyl wherein the C₃₋₆cycloalkyl may be unsubstituted or substituted once with R^(h).

In certain embodiments, R^(c) is heterocyclyl selected from oxetanyl, azetidinyl, morpholinyl and tetrahydrofuranyl, each of which may be unsubstituted or substituted once or twice with R^(h).

In certain embodiments, R^(c) is oxetanyl which may be unsubstituted or substituted once with R^(h) In certain embodiments, R^(c) is azetidinyl, which may be unsubstituted or substituted once with R^(h).

In certain embodiments, R^(c) is morpholinyl, which may be unsubstituted or substituted once or twice with R^(h).

In certain embodiments, R^(c) is tetrahydrofuranyl, which may be unsubstituted or substituted once or twice with R^(h).

In certain embodiments, R^(c) is heterocyclyl-C₁₋₆alkyl wherein the heterocyclyl is selected from oxetanyl and azetidinyl, each of which may be unsubstituted or substituted once with R^(h).

In certain embodiments, R^(c) is oxetanyl-C₁₋₆alkyl wherein the oxetanyl may be unsubstituted or substituted once with R^(h).

In certain embodiments, R^(c) is azetidin-C₁₋₆alkyl wherein the oxetanyl may be unsubstituted or substituted once with R^(h).

In certain embodiments, R^(c) is heteroaryl selected from pyrazinyl, and triazolyl, each of which may be unsubstituted or substituted once or twice with R^(h).

In certain embodiments, R^(c) is pyrazinyl which may be unsubstituted or substituted once or twice with R^(h).

In certain embodiments, R is triazolyl which may be unsubstituted or substituted once or twice with R^(h).

In certain embodiments, R is heteroaryl-C₁₋₆alkyl wherein the heteroaryl is selected from pyrazinyl, and triazolyl, each of which may be unsubstituted or substituted once or twice with R^(h).

In certain embodiments, R is pyrazinyl-C₁₋₆alkyl which may be unsubstituted or substituted once or twice with R^(h).

In certain embodiments, R is triazolyl-C₁₋₆alkyl which may be unsubstituted or substituted once or twice with R^(h).

In certain embodiments, R^(b) and R together with the nitrogen atom to which they are attached form heterocyclyl selected from azetidinyl, morpholinyl, thiomorpholinyl, and 1,1-dioxothiomorpholinyl, each of which heterocylcles may be unsubstituted or substituted once with R^(h).

In certain embodiments, R^(b) and R together with the nitrogen atom to which they are attached form azetidinyl which may be unsubstituted or substituted once with R^(h).

In certain embodiments, R^(b) and R^(c) together with the nitrogen atom to which they are attached form morpholinyl, which may be unsubstituted or substituted once with R^(h).

In certain embodiments, R^(b) and R together with the nitrogen atom to which they are attached form thiomorpholinyl, which may be unsubstituted or substituted once with R^(h).

In certain embodiments, R^(b) and R together with the nitrogen atom to which they are attached form 1,1-dioxothiomorpholinyl which may be unsubstituted or substituted once with R^(h).

In certain embodiments, R^(b) and R together with the nitrogen atom to which they are attached form pyrrolidinyl which may be unsubstituted or substituted once with R^(h).

In certain embodiments, R^(b) and R together with the nitrogen atom to which they are attached form piperidinyl which may be unsubstituted or substituted once with R^(h).

In certain embodiments, R^(b) and R together with the nitrogen atom to which they are attached form piperazinyl which may be unsubstituted or substituted once with R^(h).

In certain embodiments, R^(b) and R together with the nitrogen atom to which they are attached form azepinyl which may be unsubstituted or substituted once with R^(h).

In certain embodiments, R^(d) is C₁₋₆alkyl.

In certain embodiments, R^(d) is hydroxy-C₁₋₆alkyl.

In certain embodiments, R^(d) is C₁₋₆alkyoxy-C₁₋₆alkyl.

In certain embodiments, R^(d) is aminocarbonyl-C₁₋₆alkyl.

In certain embodiments, R^(d) is heteroaryl selected from pyridinyl, pyrimidinyl and pyrazinyl.

In certain embodiments, R^(e) is hydrogen.

In certain embodiments, R^(e) is C₁₋₆alkyl.

In certain embodiments, R^(e) is hydroxy-C₁₋₆alkyl.

In certain embodiments, R^(f) is hydrogen.

In certain embodiments, R^(f) is C₁₋₆alkyl.

In certain embodiments, R^(f) is halo-C₁₋₆alkyl.

In certain embodiments, R^(f) is cyano-C₁₋₆alkyl.

In certain embodiments, R^(f) is hydroxyl-C₁₋₆alkyl.

In certain embodiments, R^(f) is C₁₋₆alkyoxy.

In certain embodiments, R^(f) is C₁₋₆alkyoxy-C₁₋₆alkyl.

In certain embodiments, R^(f) is C₁₋₆alkylsulfonyl-C₁₋₆alkyl.

In certain embodiments, R^(f) is C₃₋₆cycloalkyl which may be unsubstituted or substituted once with R^(h).

In certain embodiments, R^(f) is C₃₋₆cycloalkyl-C₁₋₆alkyl wherein the C₃₋₆cycloalkyl may be unsubstituted or substituted once with R^(h).

In certain embodiments, R^(f) is heterocyclyl selected from oxetanyl, azetidinyl, morpholinyl and tetrahydrofuranyl, each of which may be unsubstituted or substituted once or twice with R^(h).

In certain embodiments, R^(f) is oxetanyl which may be unsubstituted or substituted once with R^(h) In certain embodiments, R^(f) is azetidinyl, which may be unsubstituted or substituted once with R^(h).

In certain embodiments, R^(f) is morpholinyl, which may be unsubstituted or substituted once or twice with R^(h).

In certain embodiments, R^(f) is tetrahydrofuranyl, which may be unsubstituted or substituted once or twice with R^(h).

In certain embodiments, R^(f) is heterocyclyl-C₁₋₆alkyl wherein the heterocyclyl is selected from oxetanyl and azetidinyl, each of which may be unsubstituted or substituted once with R^(h).

In certain embodiments, R^(f) is oxetanyl-C₁₋₆alkyl wherein the oxetanyl may be unsubstituted or substituted once with R^(h).

In certain embodiments, R^(f) is azetidin-C₁₋₆alkyl wherein the oxetanyl may be unsubstituted or substituted once with R^(h).

In certain embodiments, R^(f) is heteroaryl selected from pyrazinyl, and triazolyl, each of which may be unsubstituted or substituted once or twice with R^(h).

In certain embodiments, R^(f) is pyrazinyl which may be unsubstituted or substituted once or twice with R^(h).

In certain embodiments, R^(f) is triazolyl which may be unsubstituted or substituted once or twice with R^(h).

In certain embodiments, R^(f) is heteroaryl-C₁₋₆alkyl wherein the heteroaryl is selected from pyrazinyl, and triazolyl, each of which may be unsubstituted or substituted once or twice with R^(h).

In certain embodiments, R^(f) is pyrazinyl-C₁₋₆alkyl which may be unsubstituted or substituted once or twice with R^(h).

In certain embodiments, R^(e) and R^(f) together with the nitrogen atom to which they are attached form heterocyclyl selected from azetidinyl, morpholinyl, thiomorpholinyl, and 1,1-dioxothiomorpholinyl, each of which heterocylcles may be unsubstituted or substituted once with R^(h).

In certain embodiments, R^(e) and R^(f) together with the nitrogen atom to which they are attached form azetidinyl which may be unsubstituted or substituted once with R^(h).

In certain embodiments, R^(e) and R^(f) together with the nitrogen atom to which they are attached form morpholinyl, which may be unsubstituted or substituted once with R^(h).

In certain embodiments, R^(e) and R^(f) together with the nitrogen atom to which they are attached form thiomorpholinyl, which may be unsubstituted or substituted once with R^(h).

In certain embodiments, R^(e) and R^(f) together with the nitrogen atom to which they are attached form 1,1-dioxothiomorpholinyl which may be unsubstituted or substituted once with R^(h).

In certain embodiments, R^(e) and R^(f) together with the nitrogen atom to which they are attached form pyrrolidinyl which may be unsubstituted or substituted once with R^(h).

In certain embodiments, R^(e) and R^(f) together with the nitrogen atom to which they are attached form piperidinyl which may be unsubstituted or substituted once with R^(h).

In certain embodiments, R^(e) and R^(f) together with the nitrogen atom to which they are attached form piperazinyl which may be unsubstituted or substituted once with R^(h).

In certain embodiments, R^(e) and R^(f) together with the nitrogen atom to which they are attached form azepinyl which may be unsubstituted or substituted once with R^(h).

In certain embodiments, R′ is hydrogen.

In certain embodiments, R′ is C₁₋₆alkyl.

In certain embodiments, R^(h) is C₁₋₆alkyl.

In certain embodiments, R^(h) is cyano.

In certain embodiments, R^(h) is hydroxy.

In certain embodiments, R^(h) is oxo.

In certain embodiments, R^(h) is aminocarbonyl.

In certain embodiments, R^(h) is hydroxy-C₁₋₆alkyl.

In certain embodiments, R⁵ is:

In certain embodiments, the compounds of the invention may be of formula Ia or Ib

In certain embodiments, the compounds of the invention are of formula Ia.

In certain embodiments, the compounds of the invention are of formula Ib.

In certain embodiments, the compounds of the invention may be of formula II

wherein:

one of X and X² is N and the other is C;

X³ and X⁴ each independently is N or C; and

m, R¹, R², R³, R⁴ and R⁵ are as defined herein,

In certain embodiments of formula II, X¹ is N and X², X³, and X⁴ are C.

In certain embodiments of formula II, X² is N and X¹, X³, and X⁴ are C.

In certain embodiments of formula II, X¹ and X² are N and X³ and X⁴ are C.

In certain embodiments of formula II, X¹ and X⁴ are N and X² and X³ are C.

In certain embodiments of formula II, X² and X³ are N and X¹ and X⁴ are C.

In certain embodiments of formula II, X² and X⁴ are N and X¹ and X³ are C.

In certain embodiments, the compounds of the invention may be of formula IIa or IIb

In certain embodiments, the compounds of the invention are of formula IIa.

In certain embodiments, the compounds of the invention are of formula IIb.

In certain embodiments the subject compounds are of formula III

wherein m, R¹, R², R³, R⁴ and R⁵ are as defined herein.

In certain embodiments, the compounds of the invention may be of formula IIIa or IIIb

In certain embodiments, the compounds of the invention are of formula IIIa.

In certain embodiments, the compounds of the invention are of formula IIIb.

In certain embodiments the subject compounds are of formula IV

wherein m, R¹, R², R³, R⁴ and R⁵ are as defined herein.

In certain embodiments, the compounds of the invention may be of formula IVa or IVb

In certain embodiments, the compounds of the invention are of formula IVa.

In certain embodiments, the compounds of the invention are of formula IVb.

In certain embodiments the subject compounds are of formula V

wherein m, R¹, R², R³, R⁴ and R⁵ are as defined herein.

In certain embodiments, the compounds of the invention may be of formula Va or Vb

In certain embodiments, the compounds of the invention are of formula Va.

In certain embodiments, the compounds of the invention are of formula Vb.

In certain embodiments the subject compounds are of formula VI

wherein m, R¹, R², R³, R⁴ and R⁵ are as defined herein.

In certain embodiments, the compounds of the invention may be of formula VIa or VIb

In certain embodiments, the compounds of the invention are of formula VIa.

In certain embodiments, the compounds of the invention are of formula VIb.

In certain embodiments the subject compounds are of formula VII

wherein m, R¹, R², R³, R⁴ and R⁵ are as defined herein.

In certain embodiments, the compounds of the invention may be of formula VIa or VIb

In certain embodiments, the compounds of the invention are of formula VIIa.

In certain embodiments, the compounds of the invention are of formula VIIb.

Methods

The invention also provides a method for treating a disease or condition mediated by or otherwise associated with the RORc receptor, the method comprising administering to a subject in need thereof an effective amount of a compound of the invention.

The disease may be arthritis such as rheumatoid arthritis or osteoarthritis.

The disease may be asthma or COPD.

The disease may be psoriasis.

The disease may be muscular distrophy.

Representative compounds in accordance with the methods of the invention are shown in the experimental examples below.

Synthesis

Compounds of the present invention can be made by a variety of methods depicted in the illustrative synthetic reaction schemes shown and described below.

The starting materials and reagents used in preparing these compounds generally are either available from commercial suppliers, such as Aldrich Chemical Co., or are prepared by methods known to those skilled in the art following procedures set forth in references such as Fieser and Fieser's Reagents for Organic Synthesis; Wiley & Sons: New York, 1991, Volumes 1-15; Rodd's Chemistry of Carbon Compounds, Elsevier Science Publishers, 1989, Volumes 1-5 and Supplementals; and Organic Reactions, Wiley & Sons: New York, 1991, Volumes 1-40. The following synthetic reaction schemes are merely illustrative of some methods by which the compounds of the present invention can be synthesized, and various modifications to these synthetic reaction schemes can be made and will be suggested to one skilled in the art having referred to the disclosure contained in this Application.

The starting materials and the intermediates of the synthetic reaction schemes can be isolated and purified if desired using conventional techniques, including but not limited to, filtration, distillation, crystallization, chromatography, and the like. Such materials can be characterized using conventional means, including physical constants and spectral data.

Unless specified to the contrary, the reactions described herein may be conducted under an inert atmosphere at atmospheric pressure at a reaction temperature range of from about −78° C. to about 150° C., for example, from about 0° C. to about 125° C., or conveniently at about room (or ambient) temperature, e.g., about 20° C.

Scheme A below illustrates one synthetic procedure usable to prepare specific compounds of formula I, wherein R is lower alkyl and m, n, A, R¹, R², R⁴ and R⁵ are as defined herein.

In step 1 of Scheme A, benzophenone compound a undergoes oxidation to afford benzaldehyde compound b. This oxidation may be achieved, for example, using selenium dioxide under polar protic solvent conditions. In step 2, benzaldehyde compound b is reacted with camphor carboxylate ester c to yield camphor ketophenyl compound d. Compound d is then reacted with hydrazine in step 3 to effect a cyclization reaction and provide cinnoline carboxylate ester compound e. Ester compound e then undergoes hydrolysis in step 4 to yield the corresponding carboxy cinnoline compound f.

In step 5 carboxycinnoline compound f undergoes reaction to provide heteroaryl cinnoline compound g, which is a compound of formula I in accordance with the invention. There are many possible routes for step 4 as exemplified below. For example, the carboxylate may be converted to an N-methoxy carboxamide, which is then reacted with a vinyl reagent, followed by an acetamide reagent to make a pyridinone compound (not shown) that in turn is reduced to afford a pyridinyl group, which may be substituted as described herein. Alternatively, the N-methyl carboxamide may be converted to a methyl ketone, and then to an amino propenone, which can then under go cyclization in the presence of guanidine to yield a pyrimidinyl group (not shown). In yet another variation, the methyl ketone can be oxidized to a ketoaldehyde which is then cyclized by reaction with a 2,3-diamino-propionic acid reagent to give a pyrazinyl group (not shown)

Many variations on the procedures of Scheme A are possible and will suggest themselves to those skilled in the art. Specific details for producing compounds of the invention are described in the Examples below.

Administration and Pharmaceutical Composition

The invention includes pharmaceutical compositions comprising at least one compound of the present invention, or an individual isomer, racemic or non-racemic mixture of isomers or a pharmaceutically acceptable salt or solvate thereof, together with at least one pharmaceutically acceptable carrier, and optionally other therapeutic and/or prophylactic ingredients.

In general, the compounds of the invention will be administered in a therapeutically effective amount by any of the accepted modes of administration for agents that serve similar utilities. Suitable dosage ranges are typically 1-500 mg daily, for example 1-100 mg daily, and most preferably 1-30 mg daily, depending upon numerous factors such as the severity of the disease to be treated, the age and relative health of the subject, the potency of the compound used, the route and form of administration, the indication towards which the administration is directed, and the preferences and experience of the medical practitioner involved. One of ordinary skill in the art of treating such diseases will be able, without undue experimentation and in reliance upon personal knowledge and the disclosure of this Application, to ascertain a therapeutically effective amount of the compounds of the present invention for a given disease.

Compounds of the invention may be administered as pharmaceutical formulations including those suitable for oral (including buccal and sub-lingual), rectal, nasal, topical, pulmonary, vaginal, or parenteral (including intramuscular, intraarterial, intrathecal, subcutaneous and intravenous) administration or in a form suitable for administration by inhalation or insufflation. A particular manner of administration is generally oral using a convenient daily dosage regimen which can be adjusted according to the degree of affliction.

A compound or compounds of the invention, together with one or more conventional adjuvants, carriers, or diluents, may be placed into the form of pharmaceutical compositions and unit dosages. The pharmaceutical compositions and unit dosage forms may be comprised of conventional ingredients in conventional proportions, with or without additional active compounds or principles, and the unit dosage forms may contain any suitable effective amount of the active ingredient commensurate with the intended daily dosage range to be employed. The pharmaceutical compositions may be employed as solids, such as tablets or filled capsules, semisolids, powders, sustained release formulations, or liquids such as solutions, suspensions, emulsions, elixirs, or filled capsules for oral use; or in the form of suppositories for rectal or vaginal administration; or in the form of sterile injectable solutions for parenteral use.

Formulations containing about one (1) milligram of active ingredient or, more broadly, about 0.01 to about one hundred (100) milligrams, per tablet, are accordingly suitable representative unit dosage forms. The compounds of the invention may be formulated in a wide variety of oral administration dosage forms. The pharmaceutical compositions and dosage forms may comprise a compound or compounds of the present invention or pharmaceutically acceptable salts thereof as the active component. The pharmaceutically acceptable carriers may be either solid or liquid. Solid form preparations include powders, tablets, pills, capsules, cachets, suppositories, and dispersible granules. A solid carrier may be one or more substances which may also act as diluents, flavouring agents, solubilizers, lubricants, suspending agents, binders, preservatives, tablet disintegrating agents, or an encapsulating material. In powders, the carrier generally is a finely divided solid which is a mixture with the finely divided active component. In tablets, the active component generally is mixed with the carrier having the necessary binding capacity in suitable proportions and compacted in the shape and size desired. The powders and tablets may contain from about one (1) to about seventy (70) percent of the active compound. Suitable carriers include but are not limited to magnesium carbonate, magnesium stearate, talc, sugar, lactose, pectin, dextrin, starch, gelatine, tragacanth, methylcellulose, sodium carboxymethylcellulose, a low melting wax, cocoa butter, and the like. The term “preparation” is intended to include the formulation of the active compound with encapsulating material as carrier, providing a capsule in which the active component, with or without carriers, is surrounded by a carrier, which is in association with it. Similarly, cachets and lozenges are included. Tablets, powders, capsules, pills, cachets, and lozenges may be as solid forms suitable for oral administration.

Other forms suitable for oral administration include liquid form preparations including emulsions, syrups, elixirs, aqueous solutions, aqueous suspensions, or solid form preparations which are intended to be converted shortly before use to liquid form preparations. Emulsions may be prepared in solutions, for example, in aqueous propylene glycol solutions or may contain emulsifying agents, for example, such as lecithin, sorbitan monooleate, or acacia. Aqueous solutions can be prepared by dissolving the active component in water and adding suitable colorants, flavors, stabilizers, and thickening agents. Aqueous suspensions can be prepared by dispersing the finely divided active component in water with viscous material, such as natural or synthetic gums, resins, methylcellulose, sodium carboxymethylcellulose, and other well known suspending agents. Solid form preparations include solutions, suspensions, and emulsions, and may contain, in addition to the active component, colorants, flavors, stabilizers, buffers, artificial and natural sweeteners, dispersants, thickeners, solubilizing agents, and the like.

The compounds of the invention may be formulated for parenteral administration (e.g., by injection, for example bolus injection or continuous infusion) and may be presented in unit dose form in ampoules, pre-filled syringes, small volume infusion or in multi-dose containers with an added preservative. The compositions may take such forms as suspensions, solutions, or emulsions in oily or aqueous vehicles, for example solutions in aqueous polyethylene glycol. Examples of oily or nonaqueous carriers, diluents, solvents or vehicles include propylene glycol, polyethylene glycol, vegetable oils (e.g., olive oil), and injectable organic esters (e.g., ethyl oleate), and may contain formulatory agents such as preserving, wetting, emulsifying or suspending, stabilizing and/or dispersing agents. Alternatively, the active ingredient may be in powder form, obtained by aseptic isolation of sterile solid or by lyophilization from solution for constitution before use with a suitable vehicle, e.g., sterile, pyrogen-free water.

The compounds of the invention may be formulated for topical administration to the epidermis as ointments, creams or lotions, or as a transdermal patch. Ointments and creams may, for example, be formulated with an aqueous or oily base with the addition of suitable thickening and/or gelling agents. Lotions may be formulated with an aqueous or oily base and will in general also containing one or more emulsifying agents, stabilizing agents, dispersing agents, suspending agents, thickening agents, or coloring agents. Formulations suitable for topical administration in the mouth include lozenges comprising active agents in a flavored base, usually sucrose and acacia or tragacanth; pastilles comprising the active ingredient in an inert base such as gelatine and glycerine or sucrose and acacia; and mouthwashes comprising the active ingredient in a suitable liquid carrier.

The compounds of the invention may be formulated for administration as suppositories. A low melting wax, such as a mixture of fatty acid glycerides or cocoa butter is first melted and the active component is dispersed homogeneously, for example, by stirring. The molten homogeneous mixture is then poured into convenient sized molds, allowed to cool, and to solidify.

The compounds of the invention may be formulated for vaginal administration. Pessaries, tampons, creams, gels, pastes, foams or sprays containing in addition to the active ingredient such carriers as are known in the art to be appropriate.

The subject compounds may be formulated for nasal administration. The solutions or suspensions are applied directly to the nasal cavity by conventional means, for example, with a dropper, pipette or spray. The formulations may be provided in a single or multidose form. In the latter case of a dropper or pipette, this may be achieved by the patient administering an appropriate, predetermined volume of the solution or suspension. In the case of a spray, this may be achieved for example by means of a metering atomizing spray pump.

The compounds of the invention may be formulated for aerosol administration, particularly to the respiratory tract and including intranasal administration. The compound will generally have a small particle size for example of the order of five (5) microns or less. Such a particle size may be obtained by means known in the art, for example by micronization. The active ingredient is provided in a pressurized pack with a suitable propellant such as a chlorofluorocarbon (CFC), for example, dichlorodifluoromethane, trichlorofluoromethane, or dichlorotetrafluoroethane, or carbon dioxide or other suitable gas. The aerosol may conveniently also contain a surfactant such as lecithin. The dose of drug may be controlled by a metered valve. Alternatively the active ingredients may be provided in a form of a dry powder, for example a powder mix of the compound in a suitable powder base such as lactose, starch, starch derivatives such as hydroxypropylmethyl cellulose and polyvinylpyrrolidine (PVP). The powder carrier will form a gel in the nasal cavity. The powder composition may be presented in unit dose form for example in capsules or cartridges of e.g., gelatine or blister packs from which the powder may be administered by means of an inhaler.

When desired, formulations can be prepared with enteric coatings adapted for sustained or controlled release administration of the active ingredient. For example, the compounds of the present invention can be formulated in transdermal or subcutaneous drug delivery devices. These delivery systems are advantageous when sustained release of the compound is necessary and when patient compliance with a treatment regimen is crucial. Compounds in transdermal delivery systems are frequently attached to an skin-adhesive solid support. The compound of interest can also be combined with a penetration enhancer, e.g., Azone (1-dodecylazacycloheptan-2-one). Sustained release delivery systems are inserted subcutaneously into the subdermal layer by surgery or injection. The subdermal implants encapsulate the compound in a lipid soluble membrane, e.g., silicone rubber, or a biodegradable polymer, e.g., polylactic acid.

The pharmaceutical preparations may be in unit dosage forms. In such form, the preparation is subdivided into unit doses containing appropriate quantities of the active component. The unit dosage form can be a packaged preparation, the package containing discrete quantities of preparation, such as packeted tablets, capsules, and powders in vials or ampoules. Also, the unit dosage form can be a capsule, tablet, cachet, or lozenge itself, or it can be the appropriate number of any of these in packaged form.

Other suitable pharmaceutical carriers and their formulations are described in Remington: The Science and Practice of Pharmacy 1995, edited by E. W. Martin, Mack Publishing Company, 19th edition, Easton, Pa. Representative pharmaceutical formulations containing a compound of the present invention are described below.

Utility

The compounds of the invention are useful for treatment of immune disorders generally. The compounds may be used for treatment of arthritis, including rheumatoid arthritis, osteoarthritis, psoriatic arthritis, septic arthritis, spondyloarthropathies, gouty arthritis, systemic lupus erythematosus and juvenile arthritis, osteoarthritis, and other arthritic conditions.

The compounds may be used for treatment of respiratory disorders such as chronic obstructive pulmonary disease (COPD), asthma, bronchospasm, and the like.

The compounds may be used for treatment of gastrointestinal disorder (“GI disorder”) such as Irritable Bowel Syndrome (IBS), Inflammatory Bowel Disease (IBD), biliary colic and other biliary disorders, renal colic, diarrhea-dominant IBS, pain associated with GI distension, and the like.

The compounds may be used for treatment of pain conditions such as inflammatory pain; arthritic pain, surgical pain; visceral pain; dental pain; premenstrual pain; central pain; pain due to burns; migraine or cluster headaches; nerve injury; neuritis; neuralgias; poisoning; ischemic injury; interstitial cystitis; cancer pain; viral, parasitic or bacterial infection; post-traumatic injury; or pain associated with irritable bowel syndrome.

The compounds may be used for treatment of muscular sclerosis, Sjogren's disease, lupus, and pulmonary fibrosis.

GENERAL EXPERIMENTAL

LCMS Methods:

High Pressure Liquid Chromatography—Mass Spectrometry (LCMS) experiments to determine retention times (RT) and associated mass ions were performed using one of the following methods: Method A: Compounds were analyzed using the following conditions: Experiments were performed on a Waters ZMD single quadrupole mass spectrometer linked to a Hewlett-Packard HP1100 LC system with UV diode array detector and 100 position autosampler. The spectrometer has an electrospray source operating in positive and negative ion mode. This system uses a Phenomenex Luna 3 m C18(2) 30×4.6 mm column at ambient temperature and a 2.0 mL/min flow rate. The initial solvent system was 95% water containing 0.1% formic acid (solvent A) and 5% acetonitrile containing 0.1% formic acid (solvent B) for the first 0.5 min, followed by a gradient up to 5% solvent A and 95% solvent B over the next 4 min. This was maintained for 1 min before returning to 95% solvent A and 5% solvent B over the next 0.5 min. Total run time was 6 min.

Method B: Compounds were analysed using the following conditions: Experiments were performed on a Waters Micromass ZQ2000 quadrupole mass spectrometer linked to a Waters Acquity UPLC system with a PDA UV detector. The spectrometer has an electrospray source operating in positive and negative ion mode. This system uses an Acquity BEH C18 1.7 μm 100×2.1 mm column, maintained at 40° C. or an Acquity BEH Shield RP18 1.7 μm 100×2.1 mm column, maintained at 40° C. and a 0.4 mL/min flow rate. The initial solvent system was 95% water containing 0.1% formic acid (solvent A) and 5% acetonitrile containing 0.1% formic acid (solvent B) for the first 0.4 min followed by a gradient up to 5% solvent A and 95% solvent B over the next 5.6 min. This was maintained for 0.8 min before returning to 95% solvent A and 5% solvent B over the next 1.2 min. Total run time was 8 min.

NMR Methods:

¹H NMR spectra were recorded at ambient temperature, or at 80° C. where indicated, using one of the following machines: Varian Unity Inova (400 MHz) spectrometer with a triple resonance 5 mm probe, Bruker Avance DRX 400 (400 MHz) spectrometer with a triple resonance 5 mm probe, a Bruker Avance DPX 300 (300 MHz) equipped with a standard 5 mm dual frequency probe for detection of ¹H and ¹³C, Bruker Fourier 300 MHz system equipped with a standard 5 mm ¹H/¹³C probe, a Bruker AVIII (400 MHz) using a BBI Broad Band Inverse 5 mm probe, or a Bruker AVIII (500 MHz) using a QNP (Quad Nucleus detect) 5 mm probe. Chemical shifts are expressed in ppm relative to an internal standard, tetramethylsilane (ppm=0.00). The following abbreviations have been used: br=broad signal, s=singlet, d=doublet, dd=double doublet, t=triplet, td=triplet doublet, dddd=doublet doublet doublet doublet, q=quartet, m=multiplet, or any combination thereof.

Microwave Reactor:

Microwave reactions were carried out using a Biotage® Initiator® in vials appropriate to the scale of the reaction and at the temperature and time described in the experimental details.

Purification Equipment:

Purifications were carried out using pre-packed silica gel cartridges either on a Teledyne ISCO CombiFlash® or Biotage® Isolera Four® or using compressed air to apply external pressure. Solvents and gradients shown in the experimental details were used.

Reverse Phase High Pressure Liquid Chromatography (HPLC) was used to purify compounds where indicated. Separation using gradient elution on a Phenomenex Gemini C18 column (250×21.2 mm, 5 micron) as stationary phase and using mobile phase indicated, operating at a 18 mL/min flow rate using a Gilson UV/Vis-155 dual channel detector and Gilson GX-271 automated liquid handler.

Phase separator cartridges are supplied by Biotage® as Isolute® phase separator cartridges.

LIST OF ABBREVIATIONS

-   AcOH Acetic acid -   AIBN 2,2′-Azobis(2-methylpropionitrile) -   Atm. Atmosphere -   BOC tert-Butyloxycarbonyl group -   (BOC)₂O Di-tert-butyl dicarbonate -   CrO₃ Chromium(VI) oxide -   CDCl₃ Deuterated chloroform -   DavePhos 2-Dicyclohexylphosphino-2′-(N,N-dimethylamino)biphenyl -   DCM Dichloromethane/methylene chloride -   DMA N,N-Dimethylacetamide -   DIAD Di-iso-propyl azodicarboxylate -   DIPEA Di-iso-propylethylamine -   DMAP 4-Dimethylaminopyridine -   DME 1,2-Dimethoxyethane -   DMF N,N-Dimethylformamide -   DMSO Dimethyl sulfoxide -   DPPF 1,1′-Bis(diphenylphosphino)ferrocene -   ES Electrospray -   Et₂O Diethyl ether -   Et₃N Triethylamine -   EtOH Ethanol/Ethyl alcohol -   EtOAc Ethyl acetate -   H₂O Water -   H₂SO₄ Sulfuric acid -   HATU 2-(1H-7-Azabenzotriazol-1-yl)-1,1,3,3-tetramethyl uronium     hexafluorophosphate methanaminium -   HBTU O-Benzotriazol-1-yl-N,N,N′,N′-tetramethyluronium     hexafluorophosphate -   HCO₂H Formic acid -   HCl Hydrochloric acid -   HOBT 1-Hydroxybenzotriazole -   HPLC High pressure liquid chromatography -   RP HPLC Reverse phase high pressure liquid chromatography -   IBX 2-Iodoxybenzoic acid -   IMS Industrial methylated spirit -   KOH Potassium hydroxide -   K₂CO₃ Potassium carbonate -   LDA Lithium diisopropylamide -   i-PrOH Isopropanol/isopropyl alcohol/propan-2-ol -   LCMS Liquid Chromatograph/Mass Spectroscopy -   LiOH Lithium hydroxide -   MgSO₄ Magnesium sulphate -   MeOH Methanol/Methyl alcohol -   MW Microwaves -   NaH Sodium hydride -   NaCl Sodium chloride -   NaOH Sodium hydroxide -   Na₂SO₄ Sodium sulfate -   Na₂CO₃ Sodium carbonate -   NaHCO₃ Sodium bicarbonate/Sodium hydrogen carbonate -   NBS N-Bromosuccinimide -   NH4Cl Ammonium chloride -   NMP 1-Methyl-2-pyrrolidinone -   POCl₃ Phosphorus oxychloride -   PhCH₃ Toluene -   Pd₂(dba)₃ Tris(dibenzylideneacetone)dipalladium(0) -   PSI Pound per square inch -   RT Room temperature -   sat. Saturated -   SCX-2 Pre-packed Isolute® silica-based sorbent with a chemically     bonded propylsulfonic acid functional group -   TBDMS tert-Butyldimethylsilyl -   TFA Trifluoroacetic acid -   THF Tetrahydrofuran -   TIPS Triisopropylsilyl -   TLC Thin layer chromatography -   XantPhos 4,5-Bis(diphenylphosphino)-9,9-dimethylxanthene

Intermediate A: (1R)-5-(2,6-Fluorophenyl)-11,11-dimethyl-3,4-diazatricyclo[6.2.1.02,7]undeca-2(7),3,5-triene-1-carboxylic acid

Step 1: 2-(2,6-Difluorophenyl)-2-oxoacetaldehyde

A mixture of selenium dioxide (111 g, 1000 mmol) in 1,4-dioxane/H₂O (500 mL/20 mL) at 55° C. was stirred for 30 min and then added 1-(2,6-difluorophenyl)ethanone (156 g, 1000 mmol). The mixture was refluxed for 20 h. The reaction was cooled to room temperature and filtered. The filtrate was concentrated under reduced pressure. The residue was purified by fractional distillation collecting the fractions between 90-94° C., under vacuum (˜1 mm mercury), to afford the title compound as yellow oil (98.5 g). ¹H NMR (500 MHz, DMSO-d₆): δ 9.48 (t, J=2.0 Hz, 1H), 7.79-7.76 (m, 1H), 7.33-7.29 (m, 2H); MS (ESI): [M+H]⁺ 171.

Step 2: Methyl (1R)-3-[2-(2,6-difluorophenyl)-2-oxoethylidene]-7,7-dimethyl-2-oxobicyclo[2.2.1]heptane-1-carboxylate and (1R)-methyl 3-(2-(2,6-difluorophenyl)-1-hydroxy-2-oxoethyl)-77-dimethyl-2-oxobicyclo[2.2.1]heptane-1-carboxylate

A solution of (1R)-methyl 7,7-dimethyl-2-oxobicyclo[2.2.1]heptane-1-carboxylate (19.6 g, 100 mmol) in anhydrous THF (100 mL) at −78° C. under nitrogen was added LDA (75 mL, 2 M in THF) dropwise. The mixture was stirred at −78° C. for 1 hour, and then 2-(2,6-difluorophenyl)-2-oxoacetaldehyde (20.4 g, 120 mmol) in THF (50 mL) was added. The mixture was stirred at −78° C. for 1 h and allowed to warm to room temperature. The reaction mixture was quenched with 1 N aqueous HCl (100 mL) and concentrated under reduced pressure. The residue was extracted with EtOAc (100 mL×3). The combined organic layers were concentrated under reduced pressure and the residue was purified by chromatography on silica (1:30 EtOAc in petroleum ether) to afford the title compounds as yellow solids: methyl (1R)-3-[2-(2,6-difluorophenyl)-2-oxoethylidene]-7,7-dimethyl-2-oxobicyclo[2.2.1]heptane-1-carboxylate, (2.12 g), ¹H NMR (500 MHz, DMSO-d₆): δ 7.72-7.66 (m, 1H), 7.29-7.26 (m, 2H), 6.99 (s, 1H), 3.72 (s, 3H), 3.30-3.29 (m, 1H), 2.45-2.39 (m, 1H), 2.24-2.17 (m, 1H), 1.79-1.74 (m, 1H), 1.43-1.38 (m, 1H), 1.07 (s, 3 H), 1.03 (s, 3H); MS (ESI): [M+H]⁺ 349.1; (1R)-methyl 3-(2-(2,6-difluorophenyl)-1-hydroxy-2-oxoethyl)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptane-1-carboxylate, (5.51 g), ¹H NMR (500 MHz, DMSO-d₆): δ 7.65-7.58 (m, 1H), 7.24-7.20 (m, 2H), 6.27 (d, J=7.5 Hz, 1H), 4.63-4.60 (m, 1H), 3.66 (s, 3H), 2.28-2.23 (m, 1H), 2.04-1.97 (m, 2H), 1.87-1.81 (m, 1H), 1.51-1.46 (m, 1H), 1.89 (s, 3H), 0.99 (s, 3H); MS (ESI): [M+H]⁺ 367.1.

Step 3: Methyl (1R)-5-(2,6-fluorophenyl)-1,11-dimethyl-3,4-diazatricyclo[6.2.1.02,7]undeca-2(7),3,5-triene-1-carboxylate

A mixture of methyl (1R)-3-[2-(2,6-difluorophenyl)-2-oxoethylidene]-7,7-dimethyl-2-oxobicyclo[2.2.1]heptane-1-carboxylate (2.09 g, 6.0 mmol) and hydrazine hydrochloride (4.08 g, 60 mmol) in butan-1-ol (100 mL) was heated at 135° C. for 20 h. The reaction mixture was concentrated under reduced pressure. The residue was dissolved in H₂O (100 mL) and extracted with EtOAc (20 mL×3). The combined organic fractions were concentrated under reduced pressure and the residue was purified by chromatography on silica (3:1 petroleum ether/EtOAc) to afford the title compound as yellow solid (1.78 g). MS (ESI): [M+H]⁺ 345.1.

Following the procedure as described above and starting with (1R)-methyl 3-(2-(2,6-difluorophenyl)-1-hydroxy-2-oxoethyl)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptane-1-carboxylate (5.49 g, 15 mmol), the title compound was obtained as a yellow solid (4.39 g). MS (ESI): [M+H]⁺ 345.1.

Step 4: (1R)-5-(2,6-Fluorophenyl)-11,11-dimethyl-3,4-diazatricyclo[6.2.1.02,7]undeca-2(7),3,5-triene-1-carboxylic acid

A mixture of the product from Step 3 (5.16 g, 15 mmol) and LiOH monohydrate (0.84 g, 63.5 mmol) in THF/H₂O (50 mL/5 mL) was heated at 30° C. for 20 h. The reaction mixture was cooled to room temperature and concentrated under reduced pressure. The residue was dissolved in H₂O (100 mL) and 1N aqueous HCl added slowly until pH 3 was achieved. The mixture was extracted with EtOAc (20 mL×3) and the combined organic fractions were concentrated under reduced pressure to afford the title compound as yellow solid (4.21 g). ¹H NMR (500 MHz, DMSO-d₆): δ 12.88 (s, 1H), 7.75 (s, 1H), 7.65-7.59 (m, 1H), 7.32-7.29 (m, 1H), 3.16-3.15 (m, 1H), 2.61-2.54 (m, 1H), 2.32-2.27 (m, 1H), 1.52-1.47 (m, 1H), 1.18-1.13 (m, overlap, 4H), 0.79 (s, 3H); MS (ESI): [M+H]⁺ 331.1.

Example 1: 6-[(5R,8S)-3-(2,6-difluorophenyl)-9,9-dimethyl-6,7-dihydro-5,8-methanocinnolin-8(5H)-yl]pyridine-2-carbonitrile

Step 1: (1R,8R)-5-(2,6-Difluoro-phenyl)-11,11-dimethyl-3,4-diaza-tricyclo[6.2.1.0*2,7*]undeca-2(7),3,5-triene-1-carboxylic acid methoxy-methyl-amide

A solution of (1R,8R)-5-(2,6-difluoro-phenyl)-11,11-dimethyl-3,4-diaza-tricyclo[6.2.1.0*2,7*]undeca-2(7),3,5-triene-1-carboxylic acid (3.75 g, 11.35 mmol) in DCM (150 mL) containing DMF (3 drops) was treated with oxalyl chloride (1.44 g, 11.35 mmol) and stirred for 2 h. The reaction was concentrated in vacuo, redissolved in DCM (150 mL) and N,O-dimethylhydroxylamine.hydrochloride (1.44 g, 14.76 mmol) and Et₃N (4.71 mL, 34.05 mmol) were added and the reaction stirred for 18 h. The reaction was washed with aqueous 1N HCl, NaHCO₃, H₂O, brine, and then dried over (Na₂SO₄) and concentrated in vacuo. Purification by chromatography (0-60% EtOAc-cyclohexanes) gave the title compound as a yellow solid (3.69 g). ¹H NMR (300 MHz, CDCl₃): δ d 7.44-7.36 (m, 2H), 7.07-7.00 (m, 2H), 3.87 (s, 3H), 3.38 (s, 3H), 3.25-3.18 (m, 1H), 2.90 (d, J=4.2 Hz, 1H), 2.62 (ddd, J=3.9, 10.5, 12.9 Hz, 1H), 2.37-2.25 (m, 1H), 2.11-2.01 (m, 1H), 1.28 (s, 3H), 0.95 (s, 3H). LCMS (m/z, Method B) ES⁺ 374.18 [M+1]⁺.

Step 2: 1-[(1R,8R)-5-(2,6-Difluoro-phenyl)-11,11-dimethyl-3,4-diaza-tricyclo[6.2.1.0*2,7*]undeca-2(7),3,5-trien-1-yl]-propenone

A solution of the product from step 1 (3.68 g, 9.86 mmol) in THF (100 mL) was stirred at 0° C. and treated dropwise with vinyl magnesium bromide (14.78 mL, 1.0 M THF). The reaction was stirred at room temperature for 1.5 h, quenched with aqueous NH₄Cl and extracted into EtOAc, dried (Na₂SO₄), concentrated and purified by chromatography (0-50% EtOAc-cyclohexanes) to give the title compound as a yellow solid. ¹H NMR (300 MHz, CDCl₃) δ 7.45-7.38 (m, 2H), 7.23-7.02 (m, 3H), 6.45 (dd, J=1.9, 17.0 Hz, 1H), 5.70 (dd, J=1.9, 10.3 Hz, 1H), 3.05 (d, J=4.1 Hz, 1H), 2.82 (ddd, J=4.1, 10.5, 13.0 Hz, 1H), 2.41-2.29 (m, 1H), 1.68-1.58 (m, 1H), 1.34-1.23 (m, 1H), 1.19 (s, 3H), 0.90 (s, 3H). LCMS (m/z, Method B) ES⁺ 341.16 [M+1]⁺.

Step 3: 6-[(1S,8R)-5-(2,6-Difluoro-phenyl)-11,11-dimethyl-3,4-diaza-tricyclo[6.2.1.0*2,7*]undeca-2(7),3,5-trien-1-yl]-1H-pyridin-2-one

A mixture of the product from step 2 (1.61 g, 4.73 mmol), 1-carbamoylmethyl-pyridinium chloride (0.816 mg, 4.73 mmol) and Et₃N (0.65 mL, 4.73 mmol) in MeOH (40 mL) was heated at reflux for 4 h. The cooled reaction was concentrated in vacuo, and Ph₂O (5 mL) was added and the reaction heated to 200° C. for 15 min. The cooled reaction was extracted into EtOAc, washed with H₂O, brine, dried (Na₂SO₄), concentrated and purified by chromatography (0-10% 2M NH₃/MeOH-EtOAc) to give the title compound as a yellow solid (1.11 g). ¹H NMR (300 MHz, CDCl₃): δ 11.05-11.04 (m, 1H), 7.49-7.42 (m, 3H), 7.07 (dd, J=8.1, 8.1 Hz, 2H), 6.54 (dd, J=0.9, 9.2 Hz, 1H), 6.37 (dd, J=0.9, 7.0 Hz, 1H), 3.15 (d, J=4.1 Hz, 1H), 2.65 (ddd, J=3.8, 10.5, 12.9 Hz, 1H), 2.52-2.40 (m, 1H), 2.04 (s, 3H), 1.88-1.77 (m, 1H), 1.46-1.36 (m, 1H), 0.72 (s, 3H). LCMS (m/z, Method B) ES⁺ 380.16 [M+1]⁺.

Step 4: Trifluoro-methanesulfonic acid 6-[(1S,8R)-5-(2,6-difluoro-phenyl)-11,11-dimethyl-3,4-diaza-tricyclo[6.2.1.0*2,7*]undeca-2(7),3,5-trien-1-yl]-pyridin-2-yl ester

A solution of the product from step 3 (1.10 g, 2.9 mmol) in pyridine (10 mL) was stirred at 0° C. and treated dropwise with trifluoromethanesulfonic anhydride (976 ul, 5.8 mmol). The reaction was concentrated in vacuo after 1 h, partitioned between EtOAc-H₂O and the extracts washed with H₂O, brine, dried (Na₂SO₄) concentrated and purified by chromatography (0-40% EtOAc-cyclohexane) to give the title compound as a yellow solid (1.22 g). ¹H NMR (300 MHz, CDCl₃): δ 8.06 (d, J=7.6 Hz, 1H), 7.93 (dd, J=7.8, 7.8 Hz, 1H), 7.48-7.38 (m, 2H), 7.14-7.02 (m, 3H), 3.29 (ddd, J=4.0, 10.6, 13.2 Hz, 1H), 3.14 (d, J=4.0 Hz, 1H), 2.53-2.41 (m, 1H), 1.72-1.55 (m, 1H), 1.41-1.25 (m, 1H), 1.12 (s, 3H), 0.69 (s, 3H). LCMS (m/z, Method B) ES⁺ 512.14 [M+1]⁺.

Step 5: 6-[(5R,8S)-3-(2,6-difluorophenyl)-9,9-dimethyl-6,7-dihydro-5,8-methanocinnolin-8(5H)-yl]pyridine-2-carbonitrile

A mixture of the product from step 4 (750 mg, 1.47 mmol), zinc cyanide (430 mg, 3.67 mmol) and Pd(PPh₃)₄(85 mg, 0.074 mmol) in DMF (10 mL) was purged with nitrogen and heated at 90° C. for 3 h. The cooled reaction was diluted with EtOAc and washed with H₂O, brine, dried (Na₂SO₄) concentrated and purified by chromatography (0-60% EtOAc-cyclohexane) to give the title compound as a yellow solid (652 mg). ¹H NMR (300 MHz, CDCl₃) δ 8.13 (dd, J=1.0, 8.1 Hz, 1H), 7.86 (dd, J=7.9, 7.9 Hz, 1H), 7.66 (dd, J=1.0, 7.6 Hz, 1H), 7.49-7.39 (m, 2H), 7.06 (dd, J=8.1, 8.1 Hz, 2H), 3.43-3.32 (m, 1H), 3.16 (d, J=4.1 Hz, 1H), 2.53-2.41 (m, 1H), 1.72-1.59 (m, 1H), 1.36 (dd, J=4.2, 22.0 Hz, 1H), 1.13 (s, 3H), 0.71 (s, 3H). LCMS (m/z, Method B) ES⁺ 389.24 [M+1]⁺.

Example 2: 4-[(5R,8S)-3-(2,6-difluorophenyl)-9,9-dimethyl-6,7-dihydro-5,8-methanocinnolin-8(5H)-yl]pyrimidin-2-amine

Step 1: 1-[(1R,8R)-5-(2,6-difluoro-phenyl)-11,11-dimethyl-3,4-diaza-tricyclo[6.2.1.0*2,7*]undeca-2(7),3,5-trien-1-yl]-ethanone

A solution of (1R,8R)-5-(2,6-difluoro-phenyl)-11,11-dimethyl-3,4-diaza-tricyclo[6.2.1.0*2,7*]undeca-2(7),3,5-triene-1-carboxylic acid methoxy-methyl-amide (3.05 g, 8.17 mmol) in THF (50 mL) was stirred under N₂ and treated dropwise with methyl magnesium bromide (3.0 M Et₂O, 4.36 mL, 13.07 mmol). After 2 h, the reaction was quenched with aqueous NH₄Cl, extracted into EtOAc and washed with H₂O, brine, dried (Na₂SO₄) and concentrated in vacuo. Purification by chromatography (0-50% EtOAc-cyclohexane) gave the title compound as a yellow solid (2.11 g). ¹H NMR (300 MHz, CDCl₃) δ 7.45-7.38 (m, 2H), 7.05 (dd, J=8.1, 8.1 Hz, 2H), 3.01 (d, J=4.1 Hz, 1H), 2.72 (ddd, J=3.3, 10.3, 13.5 Hz, 1H), 2.66 (s, 3H), 2.39-2.27 (m, 1H), 1.70-1.58 (m, 1H), 1.27 (tt, J=5.7, 6.6 Hz, 1H), 1.20 (s, 3H), 0.91 (s, 3H). LCMS (m/z, Method B) ES⁺ 329.11 [M+1]⁺.

Step 2: (E)-1-[(1R,8R)-5-(2,6-Difluoro-phenyl)-11,11-dimethyl-3,4-diaza-tricyclo[6.2.1.0*2,7*]undeca-2(7),3,5-trien-1-yl]-3-dimethylamino-propenone

A solution of the product from step 1 (520 mg, 1.58 mmol) in DMF-DMA (3 mL) was heated to 120° C. in a sealed tube for 18 h. The cooled reaction was concentrated in vacuo and purified by chromatography (50-100% EtOAc-cyclohexane) to give the title compound as a yellow solid (2.11 g). ¹H NMR (300 MHz, CDCl₃) δ 7.79 (d, J=12.4 Hz, 1H), 7.43-7.36 (m, 2H), 7.04 (dd, J=8.0, 8.0 Hz, 2H), 5.80 (d, J=12.4 Hz, 1H), 3.01-2.85 (m, 2H), 2.39-2.27 (m, 1H), 1.60 (s, 1H), 1.51 (qdd, J=4.7, 5.9, 5.9 Hz, 1H), 1.21 (s, 9H), 0.86 (s, 3H). LCMS (m/z, Method B) ES⁺ 384.20 [M+1]⁺.

Step 3: 4-[(5R,8S)-3-(2,6-difluorophenyl)-9,9-dimethyl-6,7-dihydro-5,8-methanocinnolin-8(5H)-yl]pyrimidin-2-amine

A mixture of the product from step 2 (50 mg, 0.13 mmol), guanidine hydrochloride (15 mg, 0.156 mmol), K₂CO₃ (22 mg, 0.156 mmol) in EtOH (2 mL) was heated to reflux in a sealed tube for 18 h. The reaction was partitioned between H₂O-EtOAc, extracted and the organic phase washed with H₂O, brine, dried (Na₂SO₄) and concentrated in vacuo. Purification by chromatography (0-10% MeOH-DCM) and trituration with Et₂O gave the title compound as a yellow solid (23 mg). ¹H NMR (400 MHz, DMSO-d₆): δ 8.23 (d, J=5.2 Hz, 1H), 7.73 (s, 1H), 7.63-7.54 (m, 1H), 7.27 (dd, J=8.1, 8.1 Hz, 2H), 6.75 (d, J=5.2 Hz, 1H), 6.50 (s, 2H), 3.19 (d, J=4.1 Hz, 1H), 3.04 (ddd, J=3.8, 10.5, 13.0 Hz, 1H), 2.39-2.28 (m, 1H), 1.45-1.36 (m, 1H), 1.21-1.12 (m, 1H), 1.00 (s, 3H), 0.69 (s, 3H). LCMS (m/z, Method B) ES⁺380.2 [M+1]⁺.

Example 3: 6-[(5R,8R)-3-(2,6-difluorophenyl)-9,9-dimethyl-6,7-dihydro-5,8-methanocinnolin-8(5H)-yl]-N-[(2S)-2-hydroxypropyl]pyrazine-2-carboxamide

Step 1: [(1R,8R)-5-(2,6-Difluoro-phenyl)-11,11-dimethyl-3,4-diaza-tricyclo[6.2.1.0*2,7*]undeca-2(7),3,5-trien-1-yl]-oxo-acetaldehyde

A mixture of 1-[(1R,8R)-5-(2,6-difluoro-phenyl)-11,11-dimethyl-3,4-diaza-tricyclo[6.2.1.0*2,7*]undeca-2(7),3,5-trien-1-yl]-ethanone (15.13 g, 46.13 mmol) and selenium dioxide (7.68 g, 69.19 mmol) in 1,4-dioxane (250 mL) and H₂O (10 mL) was heated at 100° C. for 20 h. The cooled reaction was filtered and the filtrate evaporated and dissolved in EtOAc and filtered through a pad of silica eluting with 1.3 L of EtOAc. The filtrate was evaporated to give the title compound as a yellow foam (17.45 g) which was used directly in the next step.

Step 2: 5-[(1R,8R)-5-(26-Difluoro-phenyl)-11,11-dimethyl-3,4-diaza-tricyclo[6.2.1.0*2,7*]undeca 2(7),3,5-trien-1-yl]-2,3-dihydro-pyrazine-2-carboxylic acid methyl ester and 6-[(1R,8R)-5-(2,6-difluoro-phenyl)-11,11-dimethyl-3,4-diaza-tricyclo[6.2.1.0*2.7*]undeca-2(7),3,5-trien-1-yl]-2,3-dihydro-pyrazine-2-carboxylic acid methyl ester

Triethylamine (27.95 g, 276.8 mmol) was added to a suspension of the product from step 1 and 2,3-diamino-propionic acid methyl ester (17.63 g, 92.26 mmol) in MeOH (370 mL) and the reaction heated at 70° C. for 1 h. The cooled reaction was partitioned between EtOAc-H₂O and the organic phase dried (Na₂SO₄) and concentrated in vacuo to give the title compounds which were used directly in the next step.

Step 3: 5-[(1R,8R)-5-(2,6-Difluoro-phenyl)-11,11-dimethyl-3,4-diaza-tricyclo[6.2.1.0*2,7*]undeca-2(7),3,5-trien-1-yl]-2,3-dihydro-pyrazine-2-carboxylic acid methyl ester

The residue from step 2 was dissolved in PhCH₃ (370 mL) and manganese dioxide (40.13 g, 461.3 mmol) was added and the reaction heated at reflux for 2 h. The cooled reaction was filtered, concentrated in vacuo and purified by chromatography (0-60% EtOAc-cyclohexane). Fractions containing the title compound were dissolved in Et₂O, allowed to crystallise and collected by filtration. Filtrate and mixed fractions were re-purified to give the title compound as a white solid (5.82 g). ¹H NMR (300 MHz, CDCl₃) δ 9.26 (d, J=16.1 Hz, 2H), 7.50 (t, J=1.3 Hz, 1H), 7.42 (tt, J=6.7, 7.5 Hz, 1H), 7.06 (dd, J=8.0, 8.0 Hz, 2H), 4.04 (s, 3H), 3.44-3.33 (m, 1H), 3.19 (d, J=4.1 Hz, 1H), 2.55-2.42 (m, 1H), 1.81-1.70 (m, 1H), 1.45-1.34 (m, 1H), 1.14 (s, 3H), 0.79 (s, 3H).

Step 4: 6-[(1S,8R)-5-(2,6-Difluoro-phenyl)-11,11-dimethyl-3,4-diaza-tricyclo[6.2.1.0*2,7*]undeca-2(7),3,5-trien-1-yl]-pyrazine-2-carboxylic acid

A solution of the product from step 3 (5.81 g, 13.77 mmol) and KOH (960 mg, 17.14 mmol) in H₂O (5 mL) and MeOH (80 mL) was stirred for 0.5 h, evaporated in vacuo and the residue partitioned between H₂O-Et₂O. The aqueous phase was acidified with acetic acid and extracted with EtOAc. The organic phases were dried (Na₂SO₄) concentrated in vacuo and azeotroped twice with PhCH₃ to give the title compound as a foam. ¹H NMR (300 MHz, CDCl₃) δ 9.37 (d, J=13.8 Hz, 1H), 7.53 (t, J=1.4 Hz, 1H), 7.43 (ddd, J=9.4, 9.4, 9.4 Hz, 2H), 7.07 (td, J=4.6, 17.2 Hz, 2H), 3.30-3.20 (m, 1H), 2.57-2.45 (m, 1H), 2.06 (d, J=10.8 Hz, 1H), 1.80 (ddd, J=4.0, 9.1, 13.0 Hz, 1H), 1.48-1.38 (m, 1H), 1.12 (s, 3H), 0.80 (s, 3H).

Step 5: 6-[(5R,8R)-3-(2,6-difluorophenyl)-9,9-dimethyl-6,7-dihydro-5,8-methanocinnolin-8(5H)-yl]-N-[(2S)-2-hydroxypropyl]pyrazine-2-carboxamide

Oxalyl chloride (94 mg, 0.74 mmol) was added to a stirred solution of the product from step 4 (0.2 g, 0.49 mmol) in DCM (4 mL) containing DMF (1 drop). The solution was concentrated in vacuo after 0.5 h, dissolved in DCM (4 mL) and added to a solution of (S)-1-amino-2-propanol in DCM (4 mL). After 1 h, the solution was washed with H₂O and filtered through a phase separator cartridge, the filtrate evaporated and purified by chromatography (0-6% MeOH-DCM). Trituration with Et₂O gave the tilted compound as a white solid (168 mg). ¹H NMR (400 MHz, CDCl₃) δ 9.35 (s, 1H), 9.23 (s, 1H), 8.17 (dd, J=5.2, 5.2 Hz, 1H), 7.49 (s, 1H), 7.46-7.37 (m, 1H), 7.05 (dd, J=8.0, 8.0 Hz, 2H), 4.11-4.03 (m, 1H), 3.71 (ddd, J=3.1, 6.8, 13.9 Hz, 1H), 3.40-3.31 (m, 1H), 3.24-3.16 (m, 2H), 2.49-2.46 (m, 2H), 1.79-1.70 (m, 1H), 1.44-1.35 (m, 1H), 1.27 (d, J=6.3 Hz, 3H), 1.09 (s, 3H), 0.78 (s, 3H). LCMS (m/z, Method B) ES⁺ 466.2 [M+1]⁺.

Example 4: 2-[(5R,8R)-3-(2,6-difluorophenyl)-9,9-dimethyl-6,7-dihydro-5,8-methanocinnolin-8(5H)-yl]-N-(2-hydroxyethyl)pyrimidine-4-carboxamide

Step 1: (1R,8R)-5-(2,6-Difluoro-phenyl)-11,11-dimethyl-3,4-diaza-tricyclo[6.2.1.0*2,7*]undeca-2(7),3,5-triene-1-carboxamidine

A suspension of NH₄Cl (dried at 80° C. under vacuum prior to use, 352 mg, 6.58 mmol) in PhCH₃ (5 mL) at 0° C. was stirred under N₂ and treated dropwise with trimethylaluminium (2.0 M toluene, 2.63 mL, 5.26 mmol). After 1 h, a solution of (1R,8R)-5-(2,6-difluoro-phenyl)-11,11-dimethyl-3,4-diazatricyclo[6.2.1.0*2,7*]undeca-2(7),3,5-triene-1-carbonitrile (820 mg, 2.63 mmol) in hot toluene (15 mL) was added in one portion and the reaction heated at 80° C. for 18 h. The cooled reaction was quenched with MeOH (5 mL) and stirred for 1 h, filtered through Celite using MeOH washings and the filtrate concentrated in vacuo. Purification using SCX-2 isolute cartridge and elution with MeOH followed by 2M NH₃-MeOH gave the title compound which was used directly in the next step.

Step 2: 2-[(1R,8R)-5-(2,6-Difluoro-phenyl)-11,11-dimethyl-3,4-diaza-tricyclo[6.2.1.0*2,7*]undeca-2(7),3,5-trien-1-yl]-pyrimidine-4-carboxylic acid ethyl ester

A mixture of the product from step 1 (314 mg, 0.956 mmol) and (E)-4-ethoxy-2-oxo-but-3-enoic acid ethyl ester (0.209 mL, 1.43 mmol) in EtOH (8 mL) was heated to reflux in a sealed tube for 48 h. A further 0.5 eq (E)-4-ethoxy-2-oxo-but-3-enoic acid ethyl ester was added and heating continued for 24 h. The cooled reaction was concentrated in vacuo and purified by chromatography (0-100% EtOAc-cyclohexane) to give the title compound as an orange residue (272 mg). ¹H NMR (300 MHz, CDCl₃): δ 9.07 (d, J=5.0 Hz, 1H), 7.89 (d, J=5.0 Hz, 1H), 7.43-7.34 (m, 2H), 7.05-6.98 (m, 2H), 4.51-4.41 (m, 2H), 3.22-3.11 (m, 2H), 2.48-2.36 (m, 1H), 1.97 (tt, J=5.0, 5.7 Hz, 1H), 1.42 (dd, J=7.1, 7.1 Hz, 4H), 1.13 (s, 3H), 1.04 (s, 3H). LCMS (m/z, Method B) ES⁺ 437.23 [M+1]⁺.

Step 3: 2-[(1R,8R)-5-(2,6-Difluoro-phenyl)-11,11-dimethyl-3,4-diaza-tricyclo[6.2.1.0*2,7*]undeca-2(7),3,5-trien-1-yl]-pyrimidine-4-carboxylic acid

A solution of the product from step 2 (268 mg, 0.61 mmol) in EtOH (15 mL) was treated with lithium hydroxide solution (1 M, 1.84 mL, 1.84 mmol). After 0.5 h, the reaction was concentrated in vacuo and diluted with H₂O and washed with EtOAc. The aqueous phase was acidified to pH 2-3 using 1 N HCl and the precipitate extracted into EtOAc and DCM. The combined organics were dried (Na₂SO₄) and concentrated in vacuo to give the title compound as a beige solid (195 mg). ¹H NMR (300 MHz, DMSO-d₆) δ 9.16 (d, J=4.9 Hz, 1H), 7.97 (d, J=4.9 Hz, 1H), 7.77 (s, 1H), 7.66-7.55 (m, 1H), 7.29 (dd, J=8.1, 8.1 Hz, 2H), 3.26 (d, J=4.9 Hz, 1H), 3.14-3.03 (m, 1H), 2.46-2.36 (m, 1H), 1.79-1.69 (m, 1H), 1.36-1.17 (m, 1H), 1.02 (s, 3H), 0.93 (s, 3H). LCMS (m/z, Method B) ES⁺ 409.19 [M+1]⁺.

Step 4: 2-[(5R,8R)-3-(2,6-difluorophenyl)-9,9-dimethyl-6,7-dihydro-5,8-methanocinnolin-8(5H)-yl]-N-(2-hydroxyethyl)pyrimidine-4-carboxamide

A solution of the product from step 3 (100 mg, 0.245 mmol) in thionyl chloride (3 mL) was heated at 60° C. for 1 h. The cooled reaction was concentrated in vacuo, azeotroped with PhCH₃ and then dissolved in DCM (5 mL). The solution was added dropwise to a solution of ethanolamine (0.148 mL, 2.45 mmol) in DCM (2 mL) and allowed to stand for 1 h. The reaction was diluted with DCM, washed with aqueous 1 N citric acid, NaHCO₃, H₂O, brine, dried (Na₂SO₄) and concentrated before purification by chromatography (0-10% MeOH-EtOAc) gave the title compound as colourless residue. Trituration with MTBE-cyclohexane gave the title compound as a white solid (62 mg). ¹H NMR (400 MHz, CDCl₃) δ 9.04 (d, J=5.1 Hz, 1H), 8.58 (dd, J=6.0, 6.0 Hz, 1H), 8.01 (d, J=5.1 Hz, 1H), 7.46 (s, 1H), 7.44-7.35 (m, 1H), 7.04 (dd, J=8.0, 8.0 Hz, 2H), 3.85-3.79 (m, 2H), 3.69-3.52 (m, 2H), 3.22-3.07 (m, 3H), 2.51-2.41 (m, 1H), 1.91-1.82 (m, 1H), 1.42-1.34 (m, 1H), 1.13 (s, 3H), 0.88 (s, 3H). LCMS (m/z, Method B) ES⁺ 452.1 [M+1]⁺.

Example 5: 2-[(5R,8R)-3-(2,6-difluorophenyl)-9,9-dimethyl-6,7-dihydro-5,8-methanocinnolin-8(5H)-yl]-4H-pyran-4-one

Step 1: (1Z,4E)-1-[(1R,8R)-5-(2,6-Difluoro-phenyl)-11,11-dimethyl-3,4-diaza-tricyclo[6.2.1.0*2,7*]undeca-2(7),3,5-trien-1-yl]-1-hydroxy-5-methoxy-penta-1,4-dien-3-one

A solution of lithium bis(trimethylsilyl)amide (1 M hexanes, 30 mL, 30 mmol) was added over 5 min to a solution of trans-4-methoxy-3-buten-2-one (3 g, 30 mmol) in THF (50 mL) at −78° C. and the reaction stirred for 0.5 h. A solution of (1R,8R)-5-(2,6-difluoro-phenyl)-11,11-dimethyl-3,4-diaza-tricyclo[6.2.1.0*2,7*]undeca-2(7),3,5-triene-1-carboxylic acid (3.3 g, 10 mmol) in DCM (50 mL) containing DMF (1 drop) was treated with oxalyl chloride (1.91 g, 15 mmol) and stirred for 45 min. The reaction was concentrated in vacuo, azeotroped twice with PhCH₃ and the solid added in one portion to the solution prepared above. The reaction was stirred at −78° C. for 0.5 h then allowed to warm to room temperature, quenched with aqueous NH₄Cl, extracted into EtOAc, dried (Na₂SO₄) and concentrated before purification by chromatography (0-30% EtOAc-cyclohexanes) gave the title compound as a yellow oil (2.78 g). LCMS (m/z, Method B) ES⁺ 413.2 [M+1]⁺.

Step 2: 2-[(5R,8R)-3-(2,6-difluorophenyl)-9,9-dimethyl-6,7-dihydro-5,8-methanocinnolin-8(5H)-yl]-4H-pyran-4-one

A solution of the product from step 1 (3.92 g, 9.51 mmol) in PhCH₃ (125 mL) and trifluoroacetic acid (2.17 g, 19 mmol) was heated to 60° C. for 17 h. The cooled reaction was concentrated in vacuo and purification by chromatography (0-10% MeOH-EtOAc) gave the title compound as a brown solid (1.88 g). ¹H NMR (300 MHz, CDCl₃) δ 7.80 (d, J=5.9 Hz, 1H), 7.46-7.38 (m, 2H), 7.05 (dd, J=8.1, 8.1 Hz, 2H), 6.75 (d, J=2.4 Hz, 1H), 6.38 (dd, J=2.5, 5.9 Hz, 1H), 3.13 (d, J=4.2 Hz, 1H), 2.70 (ddd, J=4.0, 10.6, 12.7 Hz, 1H), 2.48-2.36 (m, 1H), 1.78-1.67 (m, 1H), 1.42-1.25 (m, 1H), 1.17 (s, 3H), 0.86 (s, 3H). LCMS (m/z, Method B) ES⁺ 381.2 [M+1]⁺.

Example 6: 2-[(5R,8R)-3-(2,6-difluorophenyl)-9,9-dimethyl-6,7-dihydro-5,8-methanocinnolin-8(5H)-yl]-4H-pyridin-4-one

Step 1: 2-[(5R,8R)-3-(2,6-difluorophenyl)-9,9-dimethyl-6,7-dihydro-5,8-methanocinnolin-8(5H)-yl]-4H-pyridin-4-one

A solution of 2-[(5R,8R)-3-(2,6-difluorophenyl)-9,9-dimethyl-6,7-dihydro-5,8-methanocinnolin-8(5H)-yl]-4H-pyran-4-one (1.88 g, 4.95 mmol) in NH₃-MeOH (7 M, 30 mL) was stirred at room temperature for 20 h. The reaction was concentrated in vacuo and purification by chromatography (0-20% MeOH-DCM) gave the title compound as a light brown solid (1.57 g). ¹H NMR (400 MHz, DMSO-d₆) δ 8.60 (d, J=6.9 Hz, 1H), 7.88 (s, 1H), 7.63-7.53 (m, 2H), 7.33-7.24 (m, 3H), 3.37-3.31 (m, 1H), 3.09-2.98 (m, 1H), 2.45-2.40 (m, 1H), 1.70-1.61 (m, 1H), 1.33-1.24 (m, 1H), 1.07 (s, 3H), 0.68 (s, 3H).

LCMS (m/z, Method B) ES⁺380.2 [M+1]⁺.

Example 7: 2-[(5R,8S)-3-(2,6-difluorophenyl)-9,9-dimethyl-6,7-dihydro-5,8-methanocinnolin-8(5H)-yl]pyridine-4-carbonitrile

Step 1: Trifluoro-methanesulfonic acid 2-[(1S,8R)-5-(26-difluoro-phenyl)-11,11-dimethyl-34-diaza-tricyclo[6.2.1.0*2,7*]undeca-2(7),3,5-trien-1-yl]-pyridin-4-yl ester

To an ice cold solution of 2-[(1S,8R)-5-(2,6-difluoro-phenyl)-11,11-dimethyl-3,4-diaza tricyclo[6.2.1.0*2,7*]undeca-2(7),3,5-trien-1-yl]-1H-pyridin-4-one (2.46 g, 6.49 mmol) in pyridine (2.5 mL) and DCM (50 mL) was added trifluoromethanesulfonic anhydride (2.25 g, 8.0 mmol). Cooling was removed and the reaction stirred for 0.5 h, washed with H₂O and filtered through a phase separator cartridge and evaporated in vacuo. Purification by chromatography (0-30% EtOAc-cyclohexanes) gave the title compound as a solid (3.11 g). ¹H NMR (300 MHz, CDCl₃) δ 8.78 (d, J=5.6 Hz, 1H), 7.83 (d, J=2.3 Hz, 1H), 7.49-7.38 (m, 2H), 7.23 (dd, J=2.4, 5.6 Hz, 1H), 7.06 (dd, J=8.1, 8.1 Hz, 2H), 3.37 (ddd, J=4.1, 10.6, 13.1 Hz, 1H), 3.16 (d, J=4.1 Hz, 1H), 2.53-2.41 (m, 1H), 1.75-1.64 (m, 1H), 1.43-1.31 (m, 1H), 1.10 (s, 3H), 0.72 (s, 3H). LCMS (m/z, Method B) ES⁺ 512.1 [M+1]⁺.

Step 2: 2-[(5R,8S)-3-(2,6-difluorophenyl)-99-dimethyl-6,7-dihydro-5,8-methanocinnolin-8(5H)-yl]pyridine-4-carbonitrile

A mixture of the product from step 1 (3.11 g, 6.1 mmol), zinc cyanide (1.17 g, 10 mmol), tetrakis(triphenylphosphine)palladium(0) (705 mg, 0.61 mmol) in DMF (35 mL) was heated at 90° C. under N₂ for 1 h. The cooled reaction was partitioned between H₂O-EtOAc, extracted and the organic phase washed with H₂O, brine, dried (Na₂SO₄) and concentrated in vacuo. Purification by chromatography (0-30% EtOAc-cyclohexane) gave the title compound as a white solid (2.31 mg). ¹H NMR (400 MHz, CDCl₃) δ 8.84 (d, J=4.9 Hz, 1H), 8.14 (s, 1H), 7.48-7.38 (m, 3H), 7.05 (dd, J=8.1, 8.1 Hz, 2H), 3.34 (ddd, J=4.0, 10.6, 13.1 Hz, 1H), 3.16 (d, J=4.1 Hz, 1H), 2.51-2.41 (m, 1H), 1.71-1.64 (m, 1H), 1.42-1.32 (m, 1H), 1.09 (s, 3H), 0.71 (s, 3H). LCMS (m/z, Method B) ES⁺ 389.2 [M+1]⁺.

Example 8: 2-(2-{6-[(1S,8R)-5-((1Z,3Z)-2-Fluoro-1-isopropenyl-penta-1,3-dienyl)-11,11-dimethyl-3,4-diaza-tricyclo[6.2.1.0*2,7*]undeca-2(7),3,5-trien-1-yl]-pyrazin-2-yl}-oxazol-4-yl)-propan-2-ol

Step 1: (1S,8R)-1-(6-Bromo-pyrazin-2-yl)-5-(2,6-difluoro-phenyl)-111-dimethyl-3,4-diaza-tricyclo[6.2.1.0*2,7*]undeca-2(7),3,5-triene

A suspension of 6-[(1S,8R)-5-(2,6-difluoro-phenyl)-11,11-dimethyl-3,4-diaza-tricyclo[6.2.1.0*2,7*]undeca-2(7),3,5-trien-1-yl]-pyrazine-2-carboxylic acid (3.57 g, 8.75 mmol), potassium bromide (2.60 g, 21.9 mmol) and iodine pentoxide (5.84 g, 17.5 mmol) in CH₃CN (50 mL) and H₂O (50 mL) was heated at 40° C. for 24 h. The cooled mixture was diluted with H₂O and extracted into EtOAc (3×). The combined extracts were washed with 10% sodium thiosulfate solution, brine, dried (Na₂SO₄) and concentrated in vacuo. Purification by chromatography (0-60% EtOAc-cyclohexane) afforded the title compound (2.28 g, 5.14 mmol) as an off white solid. ¹H NMR (CDCl₃, 300 MHz): δ 9.08 (s, 1H), 8.65 (s, 1H), 7.48 (t, J=1.4 Hz, 1H), 7.47-7.37 (m, 1H), 7.10-7.01 (m, 2H), 3.31-3.20 (m, 1H), 3.17 (d, J=4.1 Hz, 1H), 2.52-2.40 (m, 1H), 1.77-1.67 (m, 1H), 1.43-1.32 (m, 1H), 1.13 (s, 3H), 0.76 (s, 3H); LCMS (ESI) RT=4.14 min, M+H 443.0 and 445.0.

Step 2: 2-{6-[(1S,8R)-5-(2,6-Difluoro-phenyl)-11,11-dimethyl-3,4-diaza-tricyclo[6.2.1.0*2,7*]undeca-2(7),3,5-trien-1-yl]-pyrazin-2-yl}-oxazole-4-carboxylic acid ethyl ester

A mixture of the product from step 1 (58 mg, 131 μmol), ethyl-4-oxazole carboxylate (74 mg, 524 μmol), palladium(II) acetate (1.5 mg, 6.5 μmol), tri-o-tolylphosphine (4 mg, 13.1 μmol) and cesium carbonate (85 mg, 262 μmol) in dry toluene (1 mL) was degassed, purged with argon and heated at 110° C. for 18 h. The cooled mixture was diluted with EtOAc, washed with H₂O, brine, dried (Na₂SO₄) and concentrated in vacuo. Purification by chromatography (0-100% EtOAc-cyclohexane) afforded the title compound (56 mg, 111 μmol) as a pale yellow solid. ¹H NMR (CDCl₃, 300 MHz): δ 9.45 (s, 1H), 9.22 (s, 1H), 8.41 (s, 1H), 7.50 (s, 1H), 7.48-7.37 (m, 1H), 7.11-7.01 (m, 2H), 4.47 (q, J 7.1 Hz, 2H), 3.45-3.34 (m, 1H), 3.20 (d, J=4.0 Hz, 1H), 2.56-2.44 (m, 1H), 1.84-1.74 (m, 1H), 1.47-1.36 (m, 4H), 1.17 (s, 3H), 0.83 (s, 3H); LCMS (ESI) RT=4.00 min, M+H 504.2.

Step 3: 2-(2-{6-[(1S,8R)-5-((1Z,3Z)-2-Fluoro-1-isopropenyl-penta-3-dienyl)-11,11-dimethyl-3,4-diaza-tricyclo[6.2.1.0*27*]undeca-2(7),3,5-trien-1-yl]-pyrazin-2-yl}-oxazol-4-yl)-propan-2-ol

To a solution of the product from step 2 (205 mg, 0.41 mmol) in THF (5 mL) at 0° C. was added a solution of methyl magnesium bromide (0.3 mL, 3M in Et₂O). The reaction was quenched after 0.5 h with sat. aqueous NH₄Cl and EtOAc and the organic extracts dried (Na₂SO₄) and concentrated in vacuo. Purification by chromatography (20-80% EtOAc-cyclohexane) followed by trituration using Et₂O afforded the title compound (125 mg) as a pale yellow solid. ¹H NMR (400 MHz, CDCl₃): δ 9.34 (s, 1H), 9.17 (s, 1H), 7.71 (s, 1H), 7.50 (t, J=1.2 Hz, 1H), 7.44 (tt, J=6.3, 8.4 Hz, 1H), 7.09-7.04 (m, 2H), 3.41 (ddd, J=4.0, 10.6, 13.1 Hz, 1H), 3.19 (d, J=4.1 Hz, 1H), 2.50 (tdd, J=4.3, 10.6, 12.6 Hz, 1H), 1.78 (ddd, J=4.1, 9.1, 13.1 Hz, 1H), 1.65 (s, 6H), 1.40 (ddd, J=3.9, 9.1, 12.7 Hz, 1H), 1.16 (s, 3H), 0.82 (s, 3H), OH signal missing; LCMS (m/z) ES⁺490.2 [M+1]⁺.

Example 9: (1S,8R)-5-(2,6-Difluoro-phenyl)-1-[5-fluoro-2-(3-methyl-[1,2,4]triazol-1-yl)-pyrimidin-4-yl]-11,11-dimethyl-3,4-diaza-tricyclo[6.2.1.0*2,7*]undeca-2(7),3,5-triene

Step 1: 5-Fluoro-2-(3-methyl-[12,4]triazol-1-yl)-pyrimidine

A mixture of 2-chloro-5-fluoropyrimidine (2.39 g, 18 mmol), 3-methyl-1H-1,2,4-triazole (1.5 g, 18 mmol), potassium carbonate (5 g, 36 mmol), potassium iodide (0.3 g, 1.8 mmol) and CH₃CN (110 mL) were heated to 70° C. for 18 h. The mixture was cooled to RT, diluted with CH₂Cl₂ (220 mL), filtered through Celite and the collected precipitate washed with CH₂Cl₂. The solid resulting from solvent evaporation was purified by chromatography (1-10% MeOH—CH₂Cl₂) and recrystallised from EtOAc to give the title compound (1.01 g, 5.64 mmol) as a colourless solid. H NMR (CDCl₃, 300 MHz): δ 9.05 (s, 1H), 8.66 (s, 2H), 2.54 (s, 3H); LCMS (ESI) RT=0.43 min, [M+H]⁺ 180.1.

Step 2: (1S,8R)-5-(2,6-Difluoro-phenyl)-1-[5-fluoro-2-(3-methyl-[1,2,4]triazol-1-yl)-pyrimidin-4-yl]-11,11-dimethyl-3,4-diaza-tricyclo[6.2.1.0*2,7*]undeca-2(7),3,5-triene

A suspension of (1R,8R)-5-(2,6-difluoro-phenyl)-11,11-dimethyl-3,4-diaza tricycle[6.2.1.0*2,7*]undeca-2(7),3,5-triene-1-carboxylic acid

(0.62 g, 1.88 mmol) and the product from step 2 (1.01 g, 5.64 mmol) in CH₃CN (6.9 mL) and H₂O (6.9 mL) was heated to 70° C. Ammonium persulfate (1.71 g, 7.52 mmol) in H₂O (2.8 mL) and silver nitrate (0.128 g, 0.9 mmol) in H₂O (0.9 mL) were added. After 2 h, the CH₃CN was removed in vacuo and the residual aqueous suspension partitioned extracted with CH₂Cl₂ (2×). The combined CH₂Cl₂ extracts were washed with brine and passed through a phase-separator cartridge. The residue after evaporation of the solvent in vacuo was purified twice by silica gel chromatography (1-10% methanol-CH₂Cl₂, then 5-30% THF in chloroform) to give the title compound (0.259 g, 402 μmol) as an off-white solid. H NMR (CDCl₃, 300 MHz): δ 9.02 (s, 1H), 8.69 (d, J=2.1 Hz, 1H), 7.50 (t, J=1.3 Hz, 1H), 7.41 (tt, J=8.5, 6.3 Hz, 1H), 7.01-7.09 (m, 2H), 3.19 (d, J=4.2, 1H), 3.14 (ddd, J=14.5, 10.6, 4.2 Hz, 1H), 2.56 (s, 3H), 2.39-2.51 (m, 1H), 1.95-2.04 (m, 1H), 1.42 (ddd, J=13.0, 9.3, 4.0 Hz, 1H), 1.25 (s, 3H), 1.02 (d, J=2.7 Hz, 3H); LCMS (ESI) RT=3.48 min, [M+H]⁺ 464.1.

The above compounds, together with additional compounds made using the above procedure, are shown in Table 1 below, together with RORc IC₅₀ (micromolar) data for selected compounds determined using the assays described below.

TABLE 1 1

(5R,8R)-3-(2,6-difluorophenyl)-9,9- dimethyl-8-(pyrimidin-2-yl)-5,6,7,8- tetrahydro-5,8-methanocinnoline 0.015 2

(5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-8-(pyridazin-3-yl)-5,6,7,8- tetrahydro-5,8-methanocinnoline 0.0134 3

(5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-8-(pyrimidin-4-yl)-5,6,7,8- tetrahydro-5,8-methanocinnoline 0.0158 4

6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyridin-2(1H)-one 0.025 5

5-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2(1H)-one 0.0384 6

2-((5R,8R)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidin-5-ol 0.115 7

6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidin-2(1H)- one 0.064 8

6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-1-methyl-2-oxo- 1,2-dihydropyridine-3-carbonitrile 0.108 9

methyl 6-((5R,8S)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazine-2- carboxylate 0.0077 10

methyl 5-((5R,8S)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazine-2- carboxylate 0.389 11

6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazine-2- carboxylic acid 0.0389 12

6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazine-2- carboxamide 0.0183 13

5-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazine-2- carboxamide 4.27 14

6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazine-2- carbonitrile 0.0057 15

5-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazine-2- carbonitrile 1.31 16

6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)picolinonitrile 0.0076 17

6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N- methylpicolinamide 0.0205 18

6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N,N- dimethylpicolinamide 0.0357 19

(5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-8-(5-methylpyrimidin-4-yl)- 5,6,7,8-tetrahydro-5,8-methanocinnoline 0.0203 20

2-((5R,8R)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidin-4(3H)- one 0.14 21

(5R,8R)-3-(2,6-difluorophenyl)-8-(4- methoxypyrimidin-2-yl)-9,9-dimethyl- 5,6,7,8-tetrahydro-5,8-methanocinnoline 0.0238 22

2-((5R,8R)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-4H-pyran-4-one 0.0335 23

4-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidin-2-amine 0.0219 24

2-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyridin-4(1H)-one 1.94 25

6-((5R,8R)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-4-hydroxy-2H- pyran-2-one 2.49 26

(5R,8S)-3-(2,6-difluorophenyl)-8-(4- methoxypyridin-2-yl)-9,9-dimethyl- 5,6,7,8-tetrahydro-5,8-methanocinnoline 0.0572 27

6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N-methylpyrazine- 2-carboxamide 0.0264 28

6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N,N- dimethylpyrazine-2-carboxamide 0.0417 29

6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N-(oxetan-3- yl)pyrazine-2-carboxamide 0.0431 30

1-(6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazine-2- carbonyl)azetidine-3-carbonitrile 0.146 31

(6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2-yl)(3- (hydroxymethyl)azetidin-1-yl)methanone 0.0933 32

N-(6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2- yl)acetamide 0.022 33

6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2-amine 0.022 34

N-(6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2- yl)methanesulfonamide 0.0759 35

2-(6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2-yl)-5- methyl-1,3,4-oxadiazole 0.0217 36

6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N-(2- methoxyethyl)pyrazine-2-carboxamide 0.0371 37

(6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyridin-2- yl)(morpholino)methanone 0.0482 38

6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N-(2- hydroxyethyl)-N-methylpicolinamide 0.0377 39

6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N-(2- methoxyethyl)picolinamide 0.0116 40

6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N-(1- methylcyclopropyl)picolinamide 0.0099 41

6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N-(2- hydroxyethyl)pyrazine-2-carboxamide 0.0256 42

2-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)isonicotinonitrile 0.0121 43

2-((5R,8R)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidine-4- carbonitrile 0.027 44

6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N- methoxypicolinamide 0.0149 45

6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)picolinamide 0.00866 46

2-((5R,8R)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidine-4- carboxamide 0.0432 47

2-((5R,8R)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N- methylpyrimidine-4-carboxamide 0.0583 48

6-((5S,8R)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)picolinamide 0.0156 49

6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N-((R)-2- hydroxypropyl)pyrazine-2-carboxamide 0.0409 50

6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N-((S)-2- hydroxypropyl)pyrazine-2-carboxamide 0.0317 51

6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N-((R)-1- hydroxypropan-2-yl)pyrazine-2- carboxamide 0.059 52

6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N-((S)-1- hydroxypropan-2-yl)pyrazine-2- carboxamide 0.038 53

2-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)isonicotinic acid 0.475 54

6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N-((R)-1- hydroxypropan-2-yl)picolinamide 0.0295 55

6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N-((S)-1- hydroxypropan-2-yl)picolinamide 0.0214 56

6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N-(2- hydroxyethyl)picolinamide 0.0355 57

(6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyridin-2-yl)(1,1- dioxidothiomorpholino)methanone 0.0711 58

6-((5S,8R)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazine-2- carboxamide 0.0314 59

6-((5S,8R)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)picolinonitrile 0.0159 60

6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N-(oxetan-3- yl)picolinamide 0.0136 61

6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N-((S)-2- hydroxypropyl)picolinamide 0.0348 62

6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N-((R)-2- hydroxypropyl)picolinamide 0.0288 63

6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N-(2-hydroxy-2- methylpropyl)picolinamide 0.0531 64

2-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N-(2- hydroxyethyl)isonicotinamide 0.0954 65

2-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N-(oxetan-3- yl)isonicotinamide 0.104 66

2-(2-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyridin-4-yl)-5- methyl-1,3,4-oxadiazole 0.161 67

2-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N-((R)-1- hydroxypropan-2-yl)isonicotinamide 0.276 68

2-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N-((S)-1- hydroxypropan-2-yl)isonicotinamide 0.553 69

2-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)isonicotinamide 0.0264 70

2-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N- methylisonicotinamide 0.050 71

2-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyridin-4-amine 1.51 72

6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyridin-2-amine 0.0026 73

6-((5S,8R)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N-(2- hydroxyethyl)pyrazine-2-carboxamide 0.0324 74

N-(2-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyridin-4- yl)acetamide 0.118 75

(5-(2-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyridin-4-yl)-1,3,4- oxadiazol-2-yl)methanol 0.167 76

2-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N,N- dimethylisonicotinamide 1.47 77

2-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N-(2-hydroxy-2- methylpropyl)isonicotinamide 0.139 78

N-(2-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyridin-4- yl)methanesulfonamide 1.19 79

(2-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyridin-4- yl)methanol 0.0473 80

N-(6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyridin-2- yl)methanesulfonamide 0.0112 81

4-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N-(2- hydroxyethyl)pyrimidine-2-carboxamide 0.0528 82

6-((5S,8R)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N-(oxetan-3- yl)pyrazine-2-carboxamide 0.129 83

6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N-(2- (methylsulfonyl)ethyl)picolinamide 0.0133 84

(5-(6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2-yl)-1,3,4- oxadiazol-2-yl)methanol 0.0263 85

6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N-(3- hydroxypropyl)pyrazine-2-carboxamide 0.0306 86

6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N-(2-hydroxy-2- methylpropyl)pyrazine-2-carboxamide 0.045 87

(6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2- yl)methanol 0.0158 88

2-(6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2-yl)-5- methyloxazole 0.0054 89

6-((5S,8R)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N-((S)-2- hydroxypropyl)pyrazine-2-carboxamide 0.0128 90

N-(2-cyanoethyl)-6-((5R,8S)-3-(2,6- difluorophenyl)-9,9-dimethyl-5,6,7,8- tetrahydro-5,8-methanocinnolin-8- yl)pyrazine-2-carboxamide 0.023 91

6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N-(2- hydroxyethyl)-N-methylpyrazine-2- carboxamide 0.0408 92

N-(cyanomethyl)-6-((5R,8S)-3-(2,6- difluorophenyl)-9,9-dimethyl-5,6,7,8- tetrahydro-5,8-methanocinnolin-8- yl)pyrazine-2-carboxamide 0.0206 93

6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N-((1s,3R)-3- hydroxycyclobutyl)pyrazine-2- carboxamide 0.0318 94

6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N-((1r,3S)-3- hydroxycyclobutyl)pyrazine-2- carboxamide 0.0215 95

2-((5R,8R)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N-(2- hydroxyethyl)pyrimidine-4-carboxamide 0.117 96

6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N-(5-oxo-4,5- dihydropyrazin-2-yl)picolinamide 0.0343 97

2-((2-((5R,8R)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidin-4- yl)amino)ethanol 0.0983 98

2-((4-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidin-2- yl)amino)ethanol 0.0154 99

6-((5S,8R)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N-(2- hydroxyethyl)picolinamide 0.0409 100

6-((5S,8R)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N-((S)-2- hydroxypropyl)picolinamide 0.0413 101

N-(6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyridin-2- yl)acetamide 0.0219 102

2-(6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyridin-2-yl)-5- methyl-1,3,4-oxadiazole 0.0216 103

N-(6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2- yl)oxetane-3-carboxamide 0.0291 104

(5R,8S)-8-(6-(4H-1,2,4-triazol-3- yl)pyrazin-2-yl)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnoline 0.0259 105

(5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-8-(6-(5-methyl-4H-1,2,4-triazol- 3-yl)pyrazin-2-yl)-5,6,7,8-tetrahydro-5,8- methanocinnoline 0.0309 106

6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N-((3- hydroxyoxetan-3-yl)methyl)pyrazine-2- carboxamide 0.0311 107

6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N-((R)-2,3- dihydroxypropyl)pyrazine-2-carboxamide 0.0695 108

6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N-((S)-2,3- dihydroxypropyl)pyrazine-2-carboxamide 0.0475 109

6-((5S,8R)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N-((R)-2- hydroxypropyl)pyrazine-2-carboxamide 0.0198 110

6-((5R,8S)-3-(2,6-difluorophenyl)-9.9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N-(2- (methylsulfonyl)ethyl)pyrazine-2- carboxamide 0.0514 111

N-(4-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidin-2- yl)methanesulfonamide 0.0414 112

N-(6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyridin-2-yl)-2- hydroxyacetamide 0.0137 113

4-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidine-2- carboxamide 0.0276 114

4-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N-((S)-2- hydroxypropyl)pyrimidine-2-carboxamide 0.0388 115

4-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N-((R)-2- hydroxypropyl)pyrimidine-2-carboxamide 0.0632 116

N-((6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyridin-2- yl)methyl)-2-hydroxyacetamide 0.0152 117

2-(6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2-yl)-4- methyloxazole 0.0076 118

5-(6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2-yl)-2- methyloxazole 0.013 119

6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N-(1,3- dihydroxypropan-2-yl)pyrazine-2- carboxamide 0.0589 120

4-(6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2-yl)-2- methyloxazole 0.0086 121

(5-(6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2-yl)-4H- 1,2,4-triazol-3-yl)methanol 0.0272 122

2-((4-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidin-2- yl)amino)propane-1,3-diol 0.0386 123

3-(6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2-yl)-1H- 1,2,4-triazol-5(4H)-one 0.0325 124

6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N-((1- hydroxycyclopropyl)methyl)pyrazine-2- carboxamide 0.0508 125

3-(6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2-yl)-1,2,4- oxadiazol-5(4H)-one 0.0209 126

6-((5R,8S)-3-(2-fluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N-((S)-2- hydroxypropyl)pyrazine-2-carboxamide 0.0456 127

5-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-1,2,4-triazin-3- amine 0.109 128

2-(6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyraizn-2-yl)propan- 2-ol 0.0215 129

N-((6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2- yl)methyl)-2-hydroxyacetamide 0.0567 130

6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N-(1,3- dihydroxypropan-2-yl)picolinamide 0.0553 131

6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N-((3- hydroxyoxetan-3-yl)methyl)picolinamide 0.0444 132

3-(((4-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidin-2- yl)amino)methyl)oxetan-3-ol 0.0332 133

N-((6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2- yl)methyl)acetamide 0.0592 134

N-((6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2- yl)methyl)methanesulfonamide 0.0188 135

(2-(6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2-yl)oxazol- 4-yl)methanol 0.0233 136

4-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N-(2-hydroxy-2- methylpropyl)pyrimidine-2-carboxamide 0.0371 137

4-((6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyridin-2- yl)sulfonyl)morpholine 0.0146 138

2-(4-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidin-2-yl)-5- methyl-1,3,4-oxadiazole 0.0419 139

N-((4H-1,2,4-triazol-3-yl)methyl)-6- ((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazine-2- carboxamide 0.0655 140

6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N-(1- (hydroxymethyl)cyclopropyl)pyrazine-2- carboxamide 0.0444 141

6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N-((5-oxo-4,5- dihydro-1H-1,2,4-triazol-3- yl)methyl)pyrazine-2-carboxamide 0.113 142

(5-(6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2-yl)oxazol- 4-yl)methanol 0.0172 143

6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N-methylpyridine- 2-sulfonamide 0.0059 144

(5-(6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyridin-2-yl)-1,3,4- oxadiazol-2-yl)methanol 0.0116 145

2-(5-(6-((5R,8S)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2-yl)-1H- 1,2,4-triazol-1-yl)ethanol 0.0435 146

(5R,8S)-8-(6-(1H-tetrazol-5-yl)pyrazin-2- yl)-3-(2,6-difluorophenyl)-9,9-dimethyl- 5,6,7,8-tetrahydro-5,8-methanocinnoline 0.0319 147

6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N-(3- (hydroxymethyl)oxetan-3-yl)pyrazine-2- carboxamide 0.0506 148

5-(6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2-yl)-1,3,4- oxadiazol-2(3H)-one 0.021 149

(5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-8-(6-(5-methyl-4H-1,2,4-triazol- 3-yl)pyridin-2-yl)-5,6,7,8-tetrahydro-5,8- methanocinnoline 0.024 150

(5-(6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyridin-2-yl)-4H- 1,2,4-triazol-3-yl)methanol 0.0223 151

(5R,8S)-8-(2-(4H-1,2,4-triazol-4- yl)pyrimidin-4-yl)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnoline 0.0136 152

(3S,4S)-1-(4-((5R,8S)-3-(2,6- difluorophenyl)-9,9-dimethyl-5,6,7,8- tetrahydro-5,8-methanocinnolin-8- yl)pyrimidin-2-yl)pyrrolidine-3,4-diol 0.174 153

(S)-3-((4-((5R,8S)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidin-2- yl)amino)propane-1,2-diol 0.0157 154

(R)-3-((4-((5R,8S)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidin-2- yl)amino)propane-1,2-diol 0.0421 155

3-(((4-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidin-2- yl)amino)methyl)-1H-1,2,4-triazol-5(4H)- one 0.0658 156

N-(6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyridin-2- yl)propane-2-sulfonamide 0.0306 157

1-(6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyridin-2- yl)imidazolidin-2-one 0.0051 158

1-(6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyridin-2-yl)-3-(2- hydroxyethyl)imidazolidin-2-one 0.0261 159

5-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazine-2,3- dicarbonitrile 0.548 160

methyl 4-((5R,8S)-3-(2-chloro-6- fluorophenyl)-9,9-dimethyl-5,6,7,8- tetrahydro-5,8-methanocinnolin-8- yl)pyrimidine-2-carboxylate 0.0131 161

4-((5R,8S)-3-(2-chloro-6-fluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N-(2- hydroxyethyl)pyrimidine-2-carboxamide 0.044 162

6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N-(2- hydroxyethyl)pyridine-2-sulfonamide 0.023 163

N-((4H-1,2,4-triazol-3-yl)methyl)-4- ((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidin-2-amine 0.0192 164

N-(6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyridin-2- yl)oxetane-3-sulfonamide 0.0324 165

5-bromo-4-((5R,8S)-3-(2,6- difluorophenyl)-9,9-dimethyl-5,6,7,8- tetrahydro-5,8-methanocinnolin-8- yl)picolinonitrile 0.0251 166

5-bromo-6-((5R,8S)-3-(2,6- difluorophenyl)-9,9-dimethyl-5,6,7,8- tetrahydro-5,8-methanocinnolin-8- yl)picolinonitrile 0.0039 167

5-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-6-methylpyrazine- 2,3-dicarbonitrile 0.548 168

(5R,8S)-8-(5-bromo-2- (trifluoromethyl)pyrimidin-4-yl)-3-(2,6- difluorophenyl)-9,9-dimethyl-5,6,7,8- tetrahydro-5,8-methanocinnoline 0.0201 169

methyl 6-((5R,8S)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-5-methylpyrazine- 2-carboxylate 0.01 170

6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N-(2- hydroxyethyl)-5-methylpyrazine-2- carboxamide 0.119 171

(5R,8R)-3-(2,6-difluorophenyl)-9,9- dimethyl-8-(4-(5-methyl-4H-1,2,4-triazol- 3-yl)pyrimidin-2-yl)-5,6,7,8-tetrahydro- 5,8-methanocinnoline 0.0366 172

5-((5R,8S)-3-(2-chloro-6-fluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)picolinonitrile 0.159 173

6-((5R,8S)-3-(2-chloro-6-fluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)picolinonitrile 0.0045 174

4-(6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2-yl)-1H- imidazol-2(3H)-one 0.0085 175

5-(2-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyridin-4-yl)-2- methyloxazole 0.0134 176

methyl 4-((5R,8S)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-6- methylpyrimidine-2-carboxylate 0.0129 177

5-chloro-4-((5R,8S)-3-(2,6- difluorophenyl)-9,9-dimethyl-5,6,7,8- tetrahydro-5,8-methanocinnolin-8- yl)pyridin-2-amine 0.0244 178

(5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-8-(2-(5-methyl-4H-1,2,4-triazol- 3-yl)pyrimidin-4-yl)-5,6,7,8-tetrahydro- 5,8-methanocinnoline 0.0278 179

3-(6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyridin-2-yl)-1H- 1,2,4-triazol-5(4H)-one 0.015 180

(5-(4-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidin-2-yl)-4H- 1,2,4-triazol-3-yl)methanol 0.028 181

(5R,8S)-8-(2-(1H-imidazol-1-yl)pyrimidin- 4-yl)-3-(2,6-difluorophenyl)-9,9-dimethyl- 5,6,7,8-tetrahydro-5,8-methanocinnoline 0.0037 182

(5R,8S)-8-(2-(1H-1,2,4-triazol-1- yl)pyrimidin-4-yl)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnoline 0.0042 183

4-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N- methylpyrimidine-2-sulfonamide 0.0156 184

5-(6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2-yl)oxazole 0.0033 185

6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2(1H)-one 0.0305 186

6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-5- methylpicolinonitrile 0.0029 187

methyl 5-bromo-4-((5R,8S)-3-(2,6- difluorophenyl)-9,9-dimethyl-5,6,7,8- tetrahydro-5,8-methanocinnolin-8- yl)pyrimidine-2-carboxylate 0.0264 188

(5R,8S)-8-(2-(1H-1,2,3-triazol-1- yl)pyrimidin-4-yl)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnoline 0.0075 189

(5R,8S)-8-(2-(2H-1,2,3-triazol-2- yl)pyrimidin-4-yl)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnoline 0.0148 190

4-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N-(2- hydroxyethyl)pyrimidine-2-sulfonamide 0.0136 191

6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N-((3- hydroxyoxetan-3-yl)methyl)pyridine-2- sulfonamide 0.0246 192

4-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyridine-2,3- dicarbonitrile 0.124 193

5-bromo-4-((5R,8S)-3-(2,6- difluorophenyl)-9,9-dimethyl-5,6,7,8- tetrahydro-5,8-methanocinnolin-8-yl)-N- (2-hydroxyethyl)pyrimidine-2- carboxamide 0.0577 194

5-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N-(2- hydroxyethyl)nicotinamide 0.0242 195

(5R,8S)-8-(6-(1H-1,2,4-triazol-1- yl)pyrazin-2-yl)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnoline 0.0063 196

2-(2-(6-((5R,8S)-3-(2,6-difluorophenyl)- 9,9-diimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2-yl)oxazol- 4-yl)propan-2-ol 0.0065 197

6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N-((1r,3S)-3- hydroxy-3-methylcyclobutyl)pyrazine-2- carboxamide 0.014 198

6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N-(2-hydroxy-2- methylpropyl)pyridine-2-sulfonamide 0.0261 199

6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N-(3- (hydroxymethyl)oxetan-3-yl)pyridine-2- sulfonamide 0.0094 200

6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N-((R)-2- hydroxypropyl)pyridine-2-sulfonamide 0.0117 201

6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N-((S)-2- hydroxypropyl)pyridine-2-sulfonamide 0.0334 202

1-(6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2-yl)-1H- imidazol-2(3H)-one 0.0108 203

2-(5-(6-((5R,8S)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2-yl)-4H- 1,2,4-triazol-3-yl)propan-2-ol 0.0243 204

1-(6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2-yl)-3-(2- hydroxyethyl)urea 0.0746 205

(5R,8S)-8-(6-(1H-pyrazol-4-yl)pyrazin-2- yl)-3-(2,6-difluorophenyl)-9,9-dimethyl- 5,6,7,8-tetrahydro-5,8-methanocinnoline 0.0104 206

(5-(6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2-yl)oxazol- 2-yl)methanol 0.0067 207

(5-(6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyridin-2-yl)oxazol- 2-yl)methanol 0.0038 208

(5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-8-(2-(4-methyl-1H-imidazol-1- yl)pyrimidin-4-yl)-5,6,7,8-tetrahydro-5,8- methanocinnoline 0.0036 209

5-(6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-5-methylpyrazin-2- yl)-2-methyloxazole 0.0152 210

4-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyridine-2,6- dicarbonitrile 0.114 211

(5R,8S)-8-(2-(1H-pyrazol-1-yl)pyrimidin- 4-yl)-3-(2,6-difluorophenyl)-9,9-dimethyl- 5,6,7,8-tetrahydro-5,8-methanocinnoline 0.0088 212

(5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-8-(2-(3-methyl-1H-1,2,4-triazol- 1-yl)pyrimidin-4-yl)-5,6,7,8-tetrahydro- 5,8-methanocinnoline 0.0281 213

(5R,8S)-8-(6-(1H-pyrazol-5-yl)pyridin-2- yl)-3-(2,6-difluorophenyl)-9,9-dimethyl- 5,6,7,8-tetrahydro-5,8-methanocinnoline 0.0061 214

2-(5-(6-((5R,8S)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyridin-2-yl)-4H- 1,2,4-triazol-3-yl)propan-2-ol 0.0305 215

2-(1-(4-((5R,8S)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidin-2-yl)-1H- pyrazol-4-yl)ethanol 0.0281 216

(5R,8S)-8-(6-(4H-1,2,4-triazol-4- yl)pyridin-2-yl)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnoline 0.0127 217

(5R,8S)-3-(2,6-difluorophenyl)-8-(5- fluoropyridin-3-yl)-9,9-dimethyl-5,6,7,8- tetrahydro-5,8-methanocinnoline 0.0074 218

4-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-5-fluoro-N-(2- hydroxyethyl)pyrimidine-2-carboxamide 0.0607 219

(1-(4-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidin-2-yl)-1H- imidazol-4-yl)methanol 0.0067 220

1-(4-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidin-2-yl)-1H- 1,2,4-triazole-3-carbonitrile 0.0253 221

(R)-1-(5-(6-((5R,8S)-3-(2,6- difluorophenyl)-9,9-dimethyl-5,6,7,8- tetrahydro-5,8-methanocinnolin-8- yl)pyridin-2-yl)-4H-1,2,4-triazol-3- yl)ethanol 0.0233 222

(S)-1-(5-(6-((5R,8S)-3-(2,6- difluorophenyl)-9,9-dimethyl-5,6,7,8- tetrahydro-5,8-methanocinnolin-8- yl)pyridin-2-yl)-4H-1,2,4-triazol-3- yl)ethanol 0.011 223

(5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-8-(4-(5-methyl-4H-1,2,4-triazol- 3-yl)pyridin-2-yl)-5,6,7,8-tetrahydro-5,8- methanocinnoline 0.0623 224

(S)-1-(5-(6-((5R,8S)-3-(2,6- difluorophenyl)-9,9-dimethyl-5,6,7,8- tetrahydro-5,8-methanocinnolin-8- yl)pyrazin-2-yl)-4H-1,2,4-triazol-3- yl)ethanol 0.0124 225

(R)-1-(5-(6-((5R,8S)-3-(2,6- difluorophenyl)-9,9-dimethyl-5,6,7,8- tetrahydro-5,8-methanocinnolin-8- yl)pyrazin-2-yl)-4H-1,2,4-triazol-3- yl)ethanol 0.021 226

6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidin-4(3H)- one 0.363 227

5-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-4- methylpyrimidine-2-carbonitrile 0.717 228

4-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-6- methylpyrimidine-2-carbonitrile 0.0153 229

(5R,8S)-8-(6-(1H-pyrazol-4-yl)pyridin-2- yl)-3-(2,6-difluorophenyl)-9,9-dimethyl- 5,6,7,8-tetrahydro-5,8-methanocinnoline 0.0030 230

5-chloro-4-((5R,8S)-3-(2,6- difluorophenyl)-9,9-dimethyl-5,6,7,8- tetrahydro-5,8-methanocinnolin-8-yl)-N- (2-hydroxyethyl)pyrimidine-2- carboxamide 0.0552 231

(5R,8S)-8-(6-(1H-imidazol-1-yl)pyrazin-2- yl)-3-(2,6-difluorophenyl)-9,9-dimethyl- 5,6,7,8-tetrahydro-5,8-methanocinnoline 0.0063 232

1-(4-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidin-2-yl)-1H- 1,2,4-triazole-3-carboxamide 0.0279 233

5-chloro-4-((5R,8S)-3-(2,6- difluorophenyl)-9,9-dimethyl-5,6,7,8- tetrahydro-5,8-methanocinnolin-8- yl)pyrimidine-2-carbonitrile 0.0138 234

2-(5-(4-((5R,8S)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-5-fluoropyrimidin- 2-yl)-4H-1,2,4-triazol-3-yl)propan-2-ol 0.0366 235

(5-(2-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyridin-4-yl)oxazol- 2-yl)methanol 0.0094 236

1-(6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2-yl)-1H- imidazol-4-yl)methanol 0.0058 237

1-(6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyridin-2-yl)ethane- 1,2-diol 0.0026 238

(1-(4-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidin-2-yl)-1H- pyrazol-4-yl)methanol 0.0394 239

2-(1-(4-((5R,8S)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidin-2-yl)-1H- imidazol-4-yl)propan-2-ol 0.0139 240

2-(2-(6-((5R,8S)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyridin-2-yl)oxazol- 4-yl)propan-2-ol 0.0045 241

5-(2-((5R,8R)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidin-4-yl)-3- methylisoxazole 0.011 242

5-bromo-4-((5R,8S)-3-(2,6- difluorophenyl)-9,9-dimethyl-5,6,7,8- tetrahydro-5,8-methanocinnolin-8-yl)-3- fluoropicolinonitrile 0.005 243

(1-(6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2-yl)-1H- pyrazol-4-yl)methanol 0.0117 244

4-(2-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyridin-4-yl)-1H- imidazol-2(3H)-one 0.12 245

5-chloro-4-((5S,8R)-3-(2,6- difluorophenyl)-9,9-dimethyl-5,6,7,8- tetrahydro-5,8-methanocinnolin-8- yl)pyrimidine-2-carbonitrile 0.0264 246

(5R,8S)-8-(6-(1H-pyrazol-5-yl)pyrazin-2- yl)-3-(2,6-difluorophenyl)-9,9-dimethyl- 5,6,7,8-tetrahydro-5,8-methanocinnoline 0.0084 247

2-(5-(6-((5R,8S)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2-yl)-1H- pyrazol-3-yl)propan-2-ol 0.020 248

2-(5-(6-((5R,8S)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2-yl)-1,2,4- oxadiazol-3-yl)propan-2-ol 0.027 249

2-(5-(5-chloro-4-((5R,8S)-3-(2,6- difluorophenyl)-9,9-dimethyl-5,6,7,8- tetrahydro-5,8-methanocinnolin-8- yl)pyrimidin-2-yl)-4H-1,2,4-triazol-3- yl)propan-2-ol 0.0501 250

4-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-5-fluoropyrimidine- 2-carboxamide 0.0228 251

(5R,8S)-8-(2-(1H-pyrazol-5-yl)pyrimidin- 4-yl)-3-(2,6-difluorophenyl)-9,9-dimethyl- 5,6,7,8-tetrahydro-5,8-methanocinnoline 0.0098 252

(1-(4-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidin-2-yl)-1H- pyrazol-3-yl)methanol 0.0193 253

(5R,8S)-8-(2-(1H-pyrazol-4-yl)pyrimidin- 4-yl)-3-(2,6-difluorophenyl)-9,9-dimethyl- 5,6,7,8-tetrahydro-5,8-methanocinnoline 0.0057 254

(5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-8-(2-(pyridin-3-yl)pyrimidin-4- yl)-5,6,7,8-tetrahydro-5,8- methanocinnoline 0.0044 255

(5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-8-(6-(3-methyl-1H-1,2,4-triazol- 1-yl)pyrazin-2-yl)-5,6,7,8-tetrahydro-5,8- methanocinnoline 0.0086 256

2-(3-(6-((5R,8S)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2-yl)-1,2,4- oxadiazol-5-yl)propan-2-ol 0.0101 257

(S)-1-(5-(4-((5R,8S)-3-(2,6- difluorophenyl)-9,9-dimethyl-5,6,7,8- tetrahydro-5,8-methanocinnolin-8-yl)-5- fluoropyrimidin-2-yl)-4H-1,2,4-triazol-3- yl)ethanol 0.0226 258

(R)-1-(5-(4-((5R,8S)-3-(2,6- difluorophenyl)-9,9-dimethyl-5,6,7,8- tetrahydro-5,8-methanocinnolin-8-yl)-5- fluoropyrimidin-2-yl)-4H-1,2,4-triazol-3- yl)ethanol 0.0216 259

2-(3-(6-((5R,8S)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2- yl)isoxazol-5-yl)propan-2-ol 0.0087 260

2-(5-(6-((5R,8S)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2-yl)-1,3,4- oxadiazol-2-yl)propan-2-ol 0.0124 261

1-(4-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidin-2-yl)-1H- imidazole-4-carboxamide 0.0117 262

2-(5-(4-((5R,8S)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidin-2-yl)-4H- 1,2,4-triazol-3-yl)propan-2-ol 0.0374 263

(S)-1-(5-(4-((5R,8S)-3-(2,6- difluorophenyl)-9,9-dimethyl-5,6,7,8- tetrahydro-5,8-methanocinnolin-8- yl)pyrimidin-2-yl)-4H-1,2,4-triazol-3- yl)ethanol 0.0208 264

(R)-1-(5-(4-((5R,8S)-3-(2,6- difluorophenyl)-9,9-dimethyl-5,6,7,8- tetrahydro-5,8-methanocinnolin-8- yl)pyrimidin-2-yl)-4H-1,2,4-triazol-3- yl)ethanol 0.0323 265

2-(1-(6-((5R,8S)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2-yl)-1H- imidazol-4-yl)propan-2-ol 0.0042 266

3-(2-((5R,8R)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidin-4-yl)-5- methylisoxazole 0.0043 267

(5R,8S)-3-(2,6-difluorophenyl)-8-(5- fluoro-2-(3-methyl-1H-1,2,4-triazol-1- yl)pyrimidin-4-yl)-9,9-dimethyl-5,6,7,8- tetrahydro-5,8-methanocinnoline 0.0173 268

4-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-5-fluoropyrimidin- 2-amine 0.0033 269

2-(5-(6-((5R,8S)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2- yl)isoxazol-3-yl)propan-2-ol 0.003 270

(5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-8-(6-(3-methyl-1H-1,2,4-triazol- 1-yl)pyridin-2-yl)-5,6,7,8-tetrahydro-5,8- methanocinnoline 0.0019 271

(5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-8-(2-(3-(trifluoromethyl)-1H- 1,2,4-triazol-1-yl)pyrimidin-4-yl)-5,6,7,8- tetrahydro-5,8-methanocinnoline 0.0044 272

(5R,8S)-3-(2,6-difluorophenyl)-8-(2-(3- ethyl-1H-1,2,4-triazol-1-yl)pyrimidin-4- yl)-9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnoline 0.0029 273

(5R,8S)-3-(2,6-difluorophenyl)-8-(2-(3- isopropyl-1H-1,2,4-triazol-1-yl)pyrimidin- 4-yl)-9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnoline 0.0052 274

(5R,8S)-8-(2-(3-cyclopropyl-1H-1,2,4- triazol-1-yl)pyrimidin-4-yl)-3-(2,6- difluorophenyl)-9,9-dimethyl-5,6,7,8- tetrahydro-5,8-methanocinnoline 0.002 275

4-(2-((5R,8R)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidin-4-yl)-2- methyloxazole 0.0103 276

2-(1-(4-((5R,8S)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidin-2-yl)-1H- 1,2,4-triazol-3-yl)propan-2-ol 0.0155 277

3-(4-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-5-fluoropyrimidin- 2-yl)-N-methyl-1,2,4-oxadiazole-5- carboxamide 0.0124 278

(R)-1-(5-(6-((5R,8S)-3-(2,6- difluorophenyl)-9,9-dimethyl-5,6,7,8- tetrahydro-5,8-methanocinnolin-8- yl)pyrazin-2-yl)-1H-1,2,4-triazol-3- yl)propan-1-ol 0.0068 279

(R)-1-(5-(6-((5R,8S)-3-(2,6- difluorophenyl)-9,9-dimethyl-5,6,7,8- tetrahydro-5,8-methanocinnolin-8- yl)pyrazin-2-yl)-1H-1,2,4-triazol-3- yl)propan-2-ol 0.0126 280

2-(2-(6-((5R,8S)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2-yl)-1H- imidazol-4-yl)propan-2-ol 0.0136 281

2-(2-(2-((5R,8R)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidin-4- yl)oxazol-4-yl)propan-2-ol 0.0149 282

methyl 1-(4-((5R,8S)-3-(2,6- difluorophenyl)-9,9-dimethyl-5,6,7,8- tetrahydro-5,8-methanocinnolin-8- yl)pyrimidin-2-yl)-1H-pyrazole-3- carboxylate 0.0049 283

5-(4-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-5-fluoropyrimidin- 2-yl)-1,2,4-oxadiazole-3-carboxamide 0.0116 284

(1-(2-((5R,8R)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidin-4-yl)-1H- pyrazol-3-yl)methanol 0.0276 285

1-(5-(6-((5R,8S)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2-yl)-1H- 1,2,4-triazol-3-yl)cyclopropanol 0.0041 286

(R)-1-(5-(6-((5R,8S)-3-(2,6- difluorophenyl)-9,9-dimethyl-5,6,7,8- tetrahydro-5,8-methanocinnolin-8- yl)pyrazin-2-yl)-1H-1,2,4-triazol-3- yl)ethane-1,2-diol 0.0106 287

(1-(4-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-5-fluoropyrimidin- 2-yl)-1H-pyrazol-3-yl)methanol 0.0121 288

(5-(4-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-5-fluoropyrimidin- 2-yl)-1,2,4-oxadiazol-32-(1-(4-((5R,8S)-3- (2,6-difluorophenyl)-9,9-dimethyl-5,6,7,8- tetrahydro-5,8-methanocinnolin-8- yl)pyrimidin-2-yl)-1H-pyrazol-3- yl)propan-2-ol-yl)methanol 0.0203 289

5-(4-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidin-2- yl)pyridin-2(1H)-one 0.0151 290

2-(1-(4-((5R,8S)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidin-2-yl)-1H- pyrazol-3-yl)propan-2-ol 0.0335 291

1-(4-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidin-2-yl)-1H- pyrazole-3-carboxamide 0.0343 292

2-(3-(5-chloro-4-((5R,8S)-3-(2,6- difluorophenyl)-9,9-dimethyl-5,6,7,8- tetrahydro-5,8-methanocinnolin-8- yl)pyrimidin-2-yl)-1,2,4-oxadiazol-5- yl)propan-2-ol 0.0139 293

(S)-3-(5-(6-((5R,8S)-3-(2,6- difluorophenyl)-9,9-dimethyl-5,6,7,8- tetrahydro-5,8-methanocinnolin-8- yl)pyrazin-2-yl)-1H-1,2,4-triazol-3- yl)propane-1,2-diol 0.028 294

(5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-8-(6-(3- ((methylsulfonyl)methyl)-1H-1,2,4-triazol- 5-yl)pyrazin-2-yl)-5,6,7,8-tetrahydro-5,8- methanocinnoline 0.0233 295

(S)-1-(5-(6-((5R,8S)-3-(2,6- difluorophenyl)-9,9-dimethyl-5,6,7,8- tetrahydro-5,8-methanocinnolin-8- yl)pyrazin-2-yl)-1H-1,2,4-triazol-3- yl)propan-1-ol 0.0152 296

3-(6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2-yl)-4,5- dihydro-1,2,4-triazin-6(1H)-one 0.0209 297

(S)-1-(5-(6-((5R,8S)-3-(2,6- difluorophenyl)-9,9-dimethyl-5,6,7,8- tetrahydro-5,8-methanocinnolin-8- yl)pyrazin-2-yl)-1H-1,2,4-triazol-3- yl)propan-2-ol 0.0199 298

(5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-8-(2-(3-methyl-1H-pyrazol-4- yl)pyrimidin-4-yl)-5,6,7,8-tetrahydro-5,8- methanocinnoline 0.0057 299

1-(4-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidin-2- yl)azetidine-3-carboxamide 0.0241 300

2-(1-(4-((5R,8S)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidin-2-yl)-1H- pyrazol-3-yl)acetamide 0.0122 301

2-(4-(6-((5R,8S)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2-yl)-1H- imidazol-2-yl)propan-2-ol 0.0136 302

(5R,8R)-8-(4-(1H-pyrazol-5-yl)pyrimidin- 2-yl)-3-(2,6-difluorophenyl)-9,9-dimethyl- 5,6,7,8-tetrahydro-5,8-methanocinnoline 0.0099 303

1-(4-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidin-2-yl)-1H- pyrazol-3(2H)-one 0.015 304

2-(5-(6-((5R,8S)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyridin-2-yl)-1H- pyrazol-3-yl)propan-2-ol 0.0094 305

1-(4-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidin-2-yl)-1H- 1,2,4-triazol-3-amine 0.0196 306

2-(5-(6-((5R,8S)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2-yl)-1H- 1,2,4-triazol-3-yl)ethanol 0.0162 307

2-(1-(4-((5R,8S)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidin-2- yl)azetidin-3-yl)propan-2-ol 0.0135 308

(R)-1-(5-(6-((5R,8S)-3-(2,6- difluorophenyl)-9,9-dimethyl-5,6,7,8- tetrahydro-5,8-methanocinnolin-8- yl)pyrazin-2-yl)-1H-1,2,4-triazol-3-yl)- 2,2,2-trifluoroethanol 0.104 309

(S)-1-(5-(6-((5R,8S)-3-(2,6- difluorophenyl)-9,9-dimethyl-5,6,7,8- tetrahydro-5,8-methanocinnolin-8- yl)pyrazin-2-yl)-1H-1,2,4-triazol-3-yl)- 2,2,2-trifluoroethanol 0.0884 310

2-(5-(6-((5R,8S)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyridin-2-yl)-1H- 1,2,4-triazol-3-yl)ethanol 0.0735 311

(R)-1-(5-(6-((5R,8S)-3-(2,6- difluorophenyl)-9,9-dimethyl-5,6,7,8- tetrahydro-5,8-methanocinnolin-8- yl)pyridin-2-yl)-1H-1,2,4-triazol-3- yl)propan-2-ol 0.0711 312

(S)-1-(5-(6-((5R,8S)-3-(2,6- difluorophenyl)-9,9-dimethyl-5,6,7,8- tetrahydro-5,8-methanocinnolin-8- yl)pyridin-2-yl)-1H-1,2,4-triazol-3- yl)propan-2-ol 0.0627 313

(5-(6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyridin-2-yl)-1H- pyrazol-3-yl)methanol 0.0016 314

2-(5-(6-((5R,8S)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyridin-2-yl)-1,2,4- oxadiazol-3-yl)propan-2-ol 0.0015 315

2-((6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2- yl)oxy)acetamide 0.0941 316

1-((6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2-yl)oxy)-2- methylpropan-2-ol 0.0364 317

1-(5-(6-((5R,8S)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyridin-2-yl)-1H- 1,2,4-triazol-3-yl)cyclopropanol 0.0092 318

(R)-1-(5-(6-((5R,8S)-3-(2,6- difluorophenyl)-9,9-dimethyl-5,6,7,8- tetrahydro-5,8-methanocinnolin-8- yl)pyridin-2-yl)-1H-1,2,4-triazol-3- yl)propan-1-ol 0.0108 319

(S)-1-(5-(6-((5R,8S)-3-(2,6- difluorophenyl)-9,9-dimethyl-5,6,7,8- tetrahydro-5,8-methanocinnolin-8- yl)pyridin-2-yl)-1H-1,2,4-triazol-3- yl)propan-1-ol 0.0167 320

3-(5-(6-((5R,8S)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyridin-2-yl)-1H- 1,2,4-triazol-3-yl)oxetan-3-ol 0.009 321

(5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-8-(6-(3- ((methylsulfonyl)methyl)-1H-1,2,4-triazol- 5-yl)pyridin-2-yl)-5,6,7,8-tetrahydro-5,8- methanocinnoline 0.0127 322

(S)-1-(5-(6-((5R,8S)-3-(2,6- difluorophenyl)-9,9-dimethyl-5,6,7,8- tetrahydro-5,8-methanocinnolin-8- yl)pyridin-2-yl)-1H-1,2,4-triazol-3- yl)propan-1-ol 0.0115 323

2-(1-(4-((5R,8S)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidin-2-yl)-1H- 1,2,4-triazol-3-yl)acetamide 0.0112 324

1-(1-(4-((5R,8S)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidin-2-yl)-1H- pyrazol-3-yl)-2-methylpropan-2-ol 0.0095 325

2-(6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2- yl)oxazole-4-carboxamide 0.0067 326

2-(6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2-yl)-N-(2- hydroxyethyl)oxazole-4-carboxamide 0.0101 327

(5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-8-(2-(piperidin-1-yl)pyrimidin-4- yl)-5,6,7,8-tetrahydro-5,8- methanocinnoline 0.0020 328

4-(4-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidin-2- yl)morpholine 0.0022 329

(5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-8-(2-(pyrrolidin-1-yl)pyrimidin- 4-yl)-5,6,7,8-tetrahydro-5,8- methanocinnoline 0.0028 330

(S)-1-(4-((5R,8S)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidin-2- yl)pyrrolidin-3-ol 0.0046 331

((S)-1-(4-((5R,8S)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidin-2- yl)pyrrolidin-2-yl)methanol 0.0029 332

1-(4-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidin-2- yl)piperidin-4-ol 0.0029 333

2-((4-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidin-2- yl)oxy)ethanol 0.0048 334

((R)-4-(4-((5R,8S)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidin-2- yl)morpholin-2-yl)methanol 0.0050 335

((S)-4-(4-((5R,8S)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidin-2- yl)morpholin-2-yl)methanol 0.0062 336

6-(4-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidin-2-yl)-1- oxa-6-azaspiro[3.3]heptane 0.013 337

4-(4-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidin-2- yl)piperazin-2-one 0.006 338

(5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-8-(2-(4- (methylsulfonyl)piperazin-1-yl)pyrimidin- 4-yl)-5,6,7,8-tetrahydro-5,8- methanocinnoline 0.0032 339

(R)-1-(5-(6-((5R,8S)-3-(2,6- difluorophenyl)-9,9-dimethyl-5,6,7,8- tetrahydro-5,8-methanocinnolin-8- yl)pyridin-2-yl)-1H-1,2,4-triazol-3-yl)- 2,2,2-trifluoroethanol 0.0056 340

(S)-1-(5-(6-((5R,8S)-3-(2,6- difluorophenyl)-9,9-dimethyl-5,6,7,8- tetrahydro-5,8-methanocinnolin-8- yl)pyridin-2-yl)-1H-1,2,4-triazol-3-yl)- 2,2,2-trifluoroethanol 0.0036 341

2-(6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2- yl)oxazole-4-carbonitrile 0.0034 342

2-(2-(6-((5R,8S)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2-yl)oxazol- 5-yl)propan-2-ol 0.0117 343

2-(6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2-yl)-5- (prop-1-en-2-yl)oxazole 0.0016 344

tert-butyl 4-(4-((5R,8S)-3-(2,6- difluorophenyl)-9,9-dimethyl-5,6,7,8- tetrahydro-5,8-methanocinnolin-8- yl)pyrimidin-2-yl)-5,6-dihydropyridine- 1(2H)-carboxylate 0.0017 345

tert-butyl 4-(4-((5R,8S)-3-(2,6- difluorophenyl)-9,9-dimethyl-5,6,7,8- tetrahydro-5,8-methanocinnolin-8- yl)pyrimidin-2-yl)piperidine-1-carboxylate 0.013 346

isopropyl 2-(6-((5R,8S)-3-(2,6- difluorophenyl)-9,9-dimethyl-5,6,7,8- tetrahydro-5,8-methanocinnolin-8- yl)pyrazin-2-yl)oxazole-4-carboxylate 0.0037 347

2-(5-(6-((5R,8S)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2-yl)oxazol- 2-yl)propan-2-ol 0.0068 348

(R)-1-(1-(4-((5R,8S)-3-(2,6- difluorophenyl)-9,9-dimethyl-5,6,7,8- tetrahydro-5,8-methanocinnolin-8- yl)pyrimidin-2-yl)-1H-pyrazol-3- yl)ethanol 0.0106 349

(5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-8-(2-(1- (methylsulfonyl)piperidin-4-yl)pyrimidin- 4-yl)-5,6,7,8-tetrahydro-5,8- methanocinnoline 0.0063 350

2-(2-(4-((5R,8S)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidin-2- yl)oxazol-4-yl)propan-2-ol 0.0164 351

1-(4-(4-((5R,8S)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidin-2- yl)piperidin-1-yl)ethanone 0.0105 352

(5R,8S)-3-(2,6-difluorophenyl)-8-(2-(3,5- dimethyl-1H-1,2,4-triazol-1-yl)pyrimidin- 4-yl)-9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnoline 0.0152 353

(S)-1-(1-(4-((5R,8S)-3-(2,6- difluorophenyl)-9,9-dimethyl-5,6,7,8- tetrahydro-5,8-methanocinnolin-8- yl)pyrimidin-2-yl)-1H-pyrazol-3- yl)ethanol 0.0108 354

1-(5-(6-((5R,8S)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2-yl)-1H- 1,2,4-triazol-3-yl)-2-methylpropan-2-ol 0.0207 355

1-(4-(4-((5R,8S)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidin-2- yl)piperidin-1-yl)-2-hydroxyethanone 0.0124 356

(5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-8-(2-(tetrahydro-2H-pyran-4- yl)pyrimidin-4-yl)-5,6,7,8-tetrahydro-5,8- methanocinnoline 0.0024 357

2-(5-(6-((5R,8S)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyridin-2-yl)-1H- 1,2,4-triazol-3-yl)-2-methylpropanenitrile 0.013 358

(1-(4-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidin-2-yl)-5- methyl-1H-1,2,4-triazol-3-yl)methanol 0.0604 359

1-(4-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidin-2-yl)-1H- 1,2,4-triazol-3(2H)-one 0.0173 360

1-(4-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidin-2-yl)-5- methyl-1H-1,2,4-triazol-3(2H)-one 0.127 361

(R)-tert-butyl 3-(4-((5R,8S)-3-(2,6- difluorophenyl)-9,9-dimethyl-5,6,7,8- tetrahydro-5,8-methanocinnolin-8- yl)pyrimidin-2-yl)piperidine-1-carboxylate 0.0201 362

tert-butyl 3-(4-((5R,8S)-3-(2,6- difluorophenyl)-9,9-dimethyl-5,6,7,8- tetrahydro-5,8-methanocinnolin-8- yl)pyrimidin-2-yl)piperidine-1-carboxylate 0.0158 363

(5R,8S)-3-(2,6-difluorophenyl)-8-(5- fluoro-2-(5-methyl-1H-1,2,4-triazol-1- yl)pyrimidin-4-yl)-9,9-dimethyl-5,6,7,8- tetrahydro-5,8-methanocinnoline 0.0335 364

1-(3-(4-((5R,8S)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidin-2- yl)piperidin-1-yl)-2-hydroxyethanone 0.0504 265

(R)-1-(2-(6-((5R,8S)-3-(2,6- difluorophenyl)-9,9-dimethyl-5,6,7,8- tetrahydro-5,8-methanocinnolin-8- yl)pyrazin-2-yl)oxazol-4-yl)-2,2,2- trifluoroethanol 0.0025 366

(S)-1-(2-(6-((5R,8S)-3-(2,6- difluorophenyl)-9,9-dimethyl-5,6,7,8- tetrahydro-5,8-methanocinnolin-8- yl)pyrazin-2-yl)oxazol-4-yl)-2,2,2- trifluoroethanol 0.0035 367

(5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-8-(2-(3-methyl-1H-pyrazol-1- yl)pyrimidin-4-yl)-5,6,7,8-tetrahydro-5,8- methanocinnoline 0.0031 368

(1-(4-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidin-2-yl)-1H- 1,2,4-triazol-3-yl)methanol 0.0054 369

2-(6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2-yl)-4- ((methylsulfonyl)methyl)oxazole 0.0036 370

2-(5-(4-((5R,8S)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidin-2- yl)pyridin-2-yl)propan-2-ol 0.0044 371

2-(2-(6-((5R,8S)-3-(2-chloro-6- fluorophenyl)-9,9-dimethyl-5,6,7,8- tetrahydro-5,8-methanocinnolin-8- yl)pyrazin-2-yl)oxazol-4-yl)propan-2-ol 0.0033 372

2-(4-(4-((5R,8S)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidin-2- yl)pyridin-2-yl)propan-2-ol 0.0026 373

5-(4-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidin-2- yl)picolinamide 0.004 374

(5-(4-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidin-2- yl)pyridin-2-yl)methanol 0.0055 375

(5S,8R)-3-(2,6-difluorophenyl)-9,9- dimethyl-8-(6-(3-methyl-1H-1,2,4-triazol- 1-yl)pyrazin-2-yl)-5,6,7,8-tetrahydro-5,8- methanocinnoline 0.0104 376

6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N-((S)-5- oxotetrahydrofuran-3-yl)pyrazine-2- carboxamide 0.0272 377

3-(2-(6-((5R,8S)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2-yl)oxazol- 4-yl)pentan-3-ol 0.0053 378

(S)-1-(2-(6-((5R,8S)-3-(2,6- difluorophenyl)-9,9-dimethyl-5,6,7,8- tetrahydro-5,8-methanocinnolin-8- yl)pyrazin-2-yl)oxazol-4-yl)ethanol 0.0068 379

(R)-1-(2-(6-((5R,8S)-3-(2,6- difluorophenyl)-9,9-dimethyl-5,6,7,8- tetrahydro-5,8-methanocinnolin-8- yl)pyrazin-2-yl)oxazol-4-yl)ethanol 0.0074 380

2-(2-(6-((5R,8S)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2-yl)oxazol- 4-yl)acetonitrile 0.0061 381

(1-(6-((5S,8R)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2-yl)-1H- pyrazol-3-yl)methanol 0.006 382

(R)-1-(2-(6-((5R,8S)-3-(2,6- difluorophenyl)-9,9-dimethyl-5,6,7,8- tetrahydro-5,8-methanocinnolin-8- yl)pyrazin-2-yl)oxazol-4-yl)propan-1-ol 0.0073 383

(S)-1-(2-(6-((5R,8S)-3-(2,6- difluorophenyl)-9,9-dimethyl-5,6,7,8- tetrahydro-5,8-methanocinnolin-8- yl)pyrazin-2-yl)oxazol-4-yl)propan-1-ol 0.0082 384

2-(2-(6-((5R,8S)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2-yl)oxazol- 4-yl)acetamide 0.0069 385

3-(4-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidin-2- yl)pyridin-2-ol 0.0197 386

4-(4-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidin-2- yl)pyridin-2(1H)-one 0.0098 387

2-(2-(6-((5S,8R)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2-yl)oxazol- 4-yl)propan-2-ol 0.0080 388

2-(4-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-[2,5′-bipyrimidin]- 2′-yl)propan-2-ol 0.0073 389

(5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-8-(6-(3-methyl-1H-1,2,4-triazol- 1-yl)pyridazin-4-yl)-5,6,7,8-tetrahydro- 5,8-methanocinnoline 0.0912 390

(5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-8-(6-(5-methyl-1H-1,2,4-triazol- 1-yl)pyridazin-4-yl)-5,6,7,8-tetrahydro- 5,8-methanocinnoline 0.317 391

4-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-6-methylpyrimidin- 2-amine 0.0446 392

2-(5-(6-((5R,8S)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2- yl)pyridin-2-yl)propan-2-ol 0.0055 393

2-(4-(6-((5R,8S)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2- yl)pyridin-2-yl)propan-2-ol 0.0056 394

2-(5-(6-((5R,8S)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2- yl)pyrimidin-2-yl)propan-2-ol 0.0091 395

5-(6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2- yl)pyridin-2(1H)-one 0.0043 396

2-(2-(6-((5R,8S)-3-(2-fluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2-yl)oxazol- 4-yl)propan-2-ol 0.0048 397

2-(2-(6-((5R,8S)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2-yl)-5- methyloxazol-4-yl)propan-2-ol 0.0104 398

3-(6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2-yl)oxetan- 3-ol 0.0125 399

(5R,8S)-8-(6-(2H-1,2,3-triazol-4- yl)pyrazin-2-yl)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnoline 0.0064 400

2-(6′-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-[2,2′-bipyrazin]-5- yl)propan-2-ol 0.0087 401

5-(6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2- yl)pyrimidin-2(1H)-one 0.0147 402

2-((5-(6-((5R,8S)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2- yl)pyridin-2-yl)oxy)acetamide 0.0081 403

5-(4-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidin-2- yl)pyridin-2-amine 0.0068 404

4-(4-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidin-2- yl)picolinamide 0.0092 405

2-(4-(6-((5R,8S)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2-yl)-1H- pyrazol-1-yl)acetamide 0.0077 406

1-(4-(6-((5R,8S)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2-yl)-1H- pyrazol-1-yl)-2-methylpropan-2-ol 0.0076 407

1-(3-(6-((5R,8S)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2-yl)-1H- pyrazol-1-yl)-2-methylpropan-2-ol 0.0076 408

(5R,8R)-8-(4-(1H-imidazol-1- yl)pyrimidin-2-yl)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnoline 0.011 409

4-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-[2,5′-bipyrimidin]- 2′(1′H)-one 0.0078 410

2-((4-(6-((5R,8S)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2- yl)pyridin-2-yl)oxy)acetamide 0.0063 411

2-(3-(6-((5R,8S)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2-yl)-1H- pyrazol-1-yl)acetamide 0.0088 412

(4-(4-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidin-2- yl)pyridin-2-yl)methanol 0.0071 413

(5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-8-(6-(6- ((methylsulfonyl)methyl)pyridin-3- yl)pyrazin-2-yl)-5,6,7,8-tetrahydro-5,8- methanocinnoline 0.0050 414

N-(5-(4-((5R,8S)-3-(2,6-difluorophenyl)- 9,9-dimthyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidin-2- yl)pyridin-2-yl)methanesulfonamide 0.0098 415

2-(5-(4-((5R,8S)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrimidin-2- yl)pyrazin-2-yl)propan-2-ol 0.022 416

2-(4-(5-((5R,8S)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2- yl)pyridin-2-yl)acetonitrile 0.0029 417

(S)-1-(3-(6-((5R,8S)-3-(2,6- difluorophenyl)-9,9-dimethyl-5,6,7,8- tetrahydro-5,8-methanocinnolin-8- yl)pyrazin-2-yl)-1H-pyrazol-1-yl)propan- 2-ol 0.0056 418

(R)-N-(5-(4-((5R,8S)-3-(2,6- difluorophenyl)-9,9-dimethyl-5,6,7,8- tetrahydro-5,8-methanocinnolin-8- yl)pyrimidin-2-yl)pyridin-2-yl)-2- hydroxypropanamide 0.0105 419

5-(6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2- yl)pyridin-2-amine 0.0101 420

2-((5-(6-((5R,8S)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2- yl)pyridin-2-yl)oxy)ethanol 0.0092 421

6′-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-2H-[1,2′- bipyrazin]-2-one 0.0395 422

(5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-8-(6-(pyrazin-2-yloxy)pyrazin-2- yl)-5,6,7,8-tetrahydro-5,8- methanocinnoline 0.016 423

(S)-1-(3-(6-((5R,8S)-3-(2,6- difluorophenyl)-9,9-dimethyl-5,6,7,8- tetrahydro-5,8-methanocinnolin-8- yl)pyrazin-2-yl)-1H-pyrazol-1-yl)propan- 2-ol 0.0096 424

3-(3-(6-((5R,8S)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2-yl)-1H- pyrazol-1-yl)propanenitrile 0.0109 425

6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-N-methylpyrazine- 2-sulfonamide 0.0114 426

2-(5-bromo-2-(6-((5R,8S)-3-(2,6- difluorophenyl)-9,9-dimethyl-5,6,7,8- tetrahydro-5,8-methanocinnolin-8- yl)pyrazin-2-yl)oxazol-4-yl)propan-2-ol 0.0121 427

(R)-2-(2-(6-((5R,8S)-3-(2,6- difluorophenyl)-9,9-dimethyl-5,6,7,8- tetrahydro-5,8-methanocinnolin-8- yl)pyrazin-2-yl)oxazol-4-yl)-1,1,1- trifluoropropan-2-ol 0.0159 428

(S)-2-(2-(6-((5R,8S)-3-(2,6- difluorophenyl)-9,9-dimethyl-5,6,7,8- tetrahydro-5,8-methanocinnolin-8- yl)pyrazin-2-yl)oxazol-4-yl)-1,1,1- trifluoropropan-2-ol 0.0157 429

(S)-2-(2-(6-((5R,8S)-3-(2,6- difluorophenyl)-9,9-dimethyl-5,6,7,8- tetrahydro-5,8-methanocinnolin-8- yl)pyrazin-2-yl)oxazol-4-yl)butan-2-ol 0.0138 430

(R)-2-(2-(6-((5R,8S)-3-(2,6- difluorophenyl)-9,9-dimethyl-5,6,7,8- tetrahydro-5,8-methanocinnolin-8- yl)pyrazin-2-yl)oxazol-4-yl)butan-2-ol 0.015 431

1-(2-(6-((5R,8S)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2-yl)oxazol- 4-yl)-2,2,2-trifluoroethane-1,1-diol 0.0213 432

2-(5-chloro-2-(6-((5R,8S)-3-(2,6- difluorophenyl)-9,9-dimethyl-5,6,7,8- tetrahydro-5,8-methanocinnolin-8- yl)pyrazin-2-yl)oxazol-4-yl)propan-2-ol 0.018 433

2-(2-(6-((5R,8S)-3-(2,6-difluorophenyl)- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2-yl)-5- (hydroxymethyl)oxazol-4-yl)propan-2-ol 0.0385 434

2-(6-((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2-yl)-4- ((ethylsulfonyl)methyl)oxazole 0.011 435

4-((cyclopropylsulfonyl)methyl)-2-(6- ((5R,8S)-3-(2,6-difluorophenyl)-9,9- dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)pyrazin-2-yl)oxazole 0.0117 436

methyl 4-((5R,8S)-3-(2,6-difluorophenyl- 9,9-dimethyl-5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)-6-oxo-1,6- dihydropyridazine-3-carboxylate 0.192

Proton NMR data for selected compounds is shown below, with the compound numbers below corresponding to the numbering in Table 1:

Compound 5: ¹H NMR (CDCl₃, 300 MHz) δ 9.33 (s, 1H), 8.89 (s, 1H), 7.52 (t, J=1.3 Hz, 1H), 7.46 (tt, J=6.3, 8.4 Hz, 1H), 7.12-7.01 (m, 2H), 3.28 (ddd, J=4.1, 10.6, 13.1 Hz, 1H), 3.22 (d, J=4.1 Hz, 1H), 2.50 (tdd, J=4.3, 10.6, 12.7 Hz, 1H), 1.73 (ddd, J=4.1, 9.1, 13.2 Hz, 1H), 1.40 (ddd, J=3.9, 9.1, 12.8 Hz, 1H), 1.13 (s, 3H), 0.78 (s, 3H). Compound 9: ¹H NMR (300 MHz, CDCl3) δ 9.26 (d, J=16.1 Hz, 2H), 7.50 (t, J=1.3 Hz, 1H), 7.42 (tt, J=6.7, 7.5 Hz, 1H), 7.06 (dd, J=8.0, 8.0 Hz, 2H), 4.04 (s, 3H), 3.44-3.33 (m, 1H), 3.19 (d, J=4.1 Hz, 1H), 2.55-2.42 (m, 1H), 1.81-1.70 (m, 1H), 1.45-1.34 (m, 1H), 1.14 (s, 3H), 0.79 (s, 3H). Compound 12: ¹H NMR (300 MHz, CDCl3) δ 9.37 (d, J=13.8 Hz, 1H), 7.53 (t, J=1.4 Hz, 1H), 7.43 (ddd, J=9.4, 9.4, 9.4 Hz, 2H), 7.07 (td, J=4.6, 17.2 Hz, 2H), 3.30-3.20 (m, 1H), 2.57-2.45 (m, 1H), 2.06 (d, J=10.8 Hz, 1H), 1.80 (ddd, J=4.0, 9.1, 13.0 Hz, 1H), 1.48-1.38 (m, 1H), 1.12 (s, 3H), 0.80 (s, 3H). Compound 13: ¹H NMR (CDCl₃, 300 MHz): δ 9.39 (s, 1H), 9.28 (s, 1H), 7.59 (br s, 1H), 7.51 (apparent s, 1H), 7.44 (tt, J=6.3, 8.4 Hz, 1H), 7.12-7.01 (m, 2H), 5.71 (br s, 1H), 3.29-3.19 (m, 2H), 2.55-2.43 (m, 1H), 1.80 (ddd, J=4.0, 9.1, 13.1 Hz, 1H), 1.43 (ddd, J=3.9, 9.1, 12.8 Hz, 1H), 1.11 (s, 3H), 0.81 (s, 3H). Compound 14: ¹H NMR (400 MHz, CDCl3) δ 9.32 (s, 1H), 8.87 (s, 1H), 7.50 (s, 1H), 7.46-7.38 (m, 1H), 7.05 (dd, J=8.1, 8.1 Hz, 2H), 3.31-3.19 (m, 2H), 2.53-2.43 (m, 1H), 1.76-1.68 (m, 1H), 1.43-1.35 (m, 1H), 1.11 (s, 3H), 0.76 (s, 3H). Compound 15: ¹H NMR (300 MHz, CDCl3) δ 8.13 (dd, J=1.0, 8.1 Hz, 1H), 7.86 (dd, J=7.9, 7.9 Hz, 1H), 7.66 (dd, J=1.0, 7.6 Hz, 1H), 7.49-7.39 (m, 2H), 7.06 (dd, J=8.1, 8.1 Hz, 2H), 3.43-3.32 (m, 1H), 3.16 (d, J=4.1 Hz, 1H), 2.53-2.41 (m, 1H), 1.72-1.59 (m, 1H), 1.36 (dd, J=4.2, 22.0 Hz, 1H), 1.13 (s, 3H), 0.71 (s, 3H). Compound 22: ¹H NMR (300 MHz, CDCl3) δ 7.80 (d, J=5.9 Hz, 1H), 7.46-7.38 (m, 2H), 7.05 (dd, J=8.1, 8.1 Hz, 2H), 6.75 (d, J=2.4 Hz, 1H), 6.38 (dd, J=2.5, 5.9 Hz, 1H), 3.13 (d, J=4.2 Hz, 1H), 2.70 (ddd, J=4.0, 10.6, 12.7 Hz, 1H), 2.48-2.36 (m, 1H), 1.78-1.67 (m, 1H), 1.42-1.25 (m, 1H), 1.17 (s, 3H), 0.86 (s, 3H). Compound 23¹H NMR (400 MHz, DMSO) δ 8.23 (d, J=5.2 Hz, 1H), 7.73 (s, 1H), 7.63-7.54 (m,1H), 7.27 (dd, J=8.1, 8.1 Hz, 2H), 6.75 (d, J=5.2 Hz, 1H), 6.50 (s, 2H), 3.19 (d, J=4.1 Hz, 1H), 3.04 (ddd, J=3.8, 10.5, 13.0 Hz, 1H), 2.39-2.28 (m, 1H), 1.45-1.36 (m, 1H), 1.21-1.12 (m, 1H), 1.00 (s, 3H), 0.69 (s, 3H). Compound 24: ¹H NMR (400 MHz, DMSO) δ 8.60 (d, J=6.9 Hz, 1H), 7.88 (s, 1H), 7.63-7.53 (m, 2H), 7.33-7.24 (m, 3H), 3.37-3.31 (m, 1H), 3.09-2.98 (m, 1H), 2.45-2.40 (m, 1H), 1.70-1.61 (m, 1H), 1.33-1.24 (m, 1H), 1.07 (s, 3H), 0.68 (s, 3H). Compound 42: ¹H NMR (400 MHz, CDCl3) δ 8.84 (d, J=4.9 Hz, 1H), 8.14 (s, 1H), 7.48-7.38 (m, 3H), 7.05 (dd, J=8.1, 8.1 Hz, 2H), 3.34 (ddd, J=4.0, 10.6, 13.1 Hz, 1H), 3.16 (d, J=4.1 Hz, 1H), 2.51-2.41 (m, 1H), 1.71-1.64 (m, 1H), 1.42-1.32 (m, 1H), 1.09 (s, 3H), 0.71 (s, 3H). Compound 50: ¹H NMR (400 MHz, CDCl3) δ 9.35 (s, 1H), 9.23 (s, 1H), 8.17 (dd, J=5.2, 5.2 Hz, 1H), 7.49 (s, 1H), 7.46-7.37 (m, 1H), 7.05 (dd, J=8.0, 8.0 Hz, 2H), 4.11-4.03 (m, 1H), 3.71 (ddd, J=3.1, 6.8, 13.9 Hz, 1H), 3.40-3.31 (m, 1H), 3.24-3.16 (m, 2H), 2.49-2.46 (m, 2H), 1.79-1.70 (m, 1H), 1.44-1.35 (m, 1H), 1.27 (d, J=6.3 Hz, 3H), 1.09 (s, 3H), 0.78 (s, 3H). Compound 59: ¹H NMR (300 MHz, CDCl3) δ 8.13 (dd, J=1.0, 8.1 Hz, 1H), 7.86 (dd, J=7.9, 7.9 Hz, 1H), 7.66 (dd, J=1.0, 7.6 Hz, 1H), 7.49-7.39 (m, 2H), 7.06 (dd, J=8.1, 8.1 Hz, 2H), 3.43-3.32 (m, 1H), 3.16 (d, J=4.1 Hz, 1H), 2.53-2.41 (m, 1H), 1.72-1.59 (m, 1H), 1.36 (dd, J=4.2, 22.0 Hz, 1H), 1.13 (s, 3H), 0.71 (s, 3H). Compound 63: ¹H NMR (400 MHz, CDCl3) δ 8.47 (dd, J=5.5, 5.5 Hz, 1H), 8.16 (dd, J=1.0, 7.6 Hz, 1H), 8.03 (dd, J=1.1, 7.9 Hz, 1H), 7.91 (dd, J=7.7, 7.7 Hz, 1H), 7.46 (s, 1H), 7.45-7.36 (m, 1H), 7.05 (dd, J=8.0, 8.0 Hz, 2H), 3.51 (dd, J=3.0, 6.3 Hz, 2H), 3.27 (ddd, J=4.0, 10.5, 13.0 Hz, 1H), 3.15 (d, J=4.1 Hz, 1H), 2.52-2.42 (m, 1H), 1.79-1.71 (m, 1H), 1.43-1.35 (m, 1H), 1.29 (s, 6H), 1.11 (s, 3H), 0.74 (s, 3H). Compound 87: ¹H NMR (400 MHz, CDCl3) δ 9.02 (s, 1H), 8.56 (s, 1H), 7.48 (s, 1H), 7.45-7.36 (m, 1H), 7.05 (dd, J=8.0, 8.0 Hz, 2H), 4.87 (d, J=5.3 Hz, 2H), 3.38-3.25 (m, 2H), 3.17 (d, J=4.1 Hz, 1H), 2.51-2.41 (m, 1H), 1.77-1.68 (m, 1H), 1.41-1.35 (m, 1H), 1.08 (s, 3H), 0.78 (s, 3H). Compound 88: ¹H NMR (400 MHz, CDCl3) δ 9.24 (s, 1H), 9.12 (s, 1H), 7.48 (s, 1H), 7.45-7.36 (m, 1H), 7.07-6.98 (m, 3H), 3.45 (ddd, J=4.0, 10.5, 13.2 Hz, 1H), 3.18 (d, J=4.1 Hz, 1H), 2.47 (d, J=1.0 Hz, 4H), 1.80-1.72 (m, 1H), 1.42-1.34 (m, 1H), 1.15 (s, 3H), 0.80 (s, 3H). Compound 95: ¹H NMR (400 MHz, CDCl3) δ 9.04 (d, J=5.1 Hz, 1H), 8.58 (dd, J=6.0, 6.0 Hz, 1H), 8.01 (d, J=5.1 Hz, 1H), 7.46 (s, 1H), 7.44-7.35 (m, 1H), 7.04 (dd, J=8.0, 8.0 Hz, 2H), 3.85-3.79 (m, 2H), 3.69-3.52 (m, 2H), 3.22-3.07 (m, 3H), 2.51-2.41 (m, 1H), 1.91-1.82 (m, 1H), 1.42-1.34 (m, 1H), 1.13 (s, 3H), 0.88 (s, 3H). Compound 98: ¹H NMR (400 MHz, CDCl3) δ 8.29 (d, J=5.3 Hz, 1H), 7.44-7.36 (m, 2H), 7.10-7.01 (m, 3H), 5.46 (dd, J=5.7, 5.7 Hz, 1H), 3.85 (dd, J=4.6, 4.6 Hz, 2H), 3.66-3.59 (m, 3H), 3.18 (ddd, J=4.0, 10.6, 13.2 Hz, 1H), 3.10 (d, J=4.1 Hz, 1H), 2.46-2.36 (m, 1H), 1.36-1.17 (m, 1H), 1.11 (s, 3H), 0.87 (dd, J=7.1, 7.1 Hz, 1H), 0.74 (s, 3H). Compound 102: ¹H NMR (400 MHz, CDCl3) δ 8.13 (d, J=7.7 Hz, 1H), 8.02 (d, J=7.4 Hz, 1H), 7.89 (dd, J=7.9, 7.9 Hz, 1H), 7.46 (s, 1H), 7.45-7.36 (m, 1H), 7.04 (dd, J=8.0, 8.0 Hz, 2H), 3.48 (ddd, J=4.1, 10.5, 13.1 Hz, 1H), 3.15 (d, J=4.1 Hz, 1H), 2.67 (s, 3H), 2.52-2.42 (m, 1H), 1.76-1.68 (m, 1H), 1.41-1.32 (m, 1H), 1.15 (s, 3H), 0.75 (s, 3H). Compound 104: ¹H NMR (400 MHz, CDCl3) δ 12.02-12.02 (m, 1H), 9.35 (s, 1H), 9.13 (s, 1H), 8.16 (s, 1H), 7.50 (s, 1H), 7.46-7.37 (m, 1H), 7.05 (dd, J=8.0, 8.0 Hz, 2H), 3.33-3.23 (m, 1H), 3.20 (d, J=4.1 Hz, 1H), 2.51-2.40 (m, 1H), 1.78-1.69 (m, 1H), 1.42-1.33 (m, 1H), 1.09 (s, 3H), 0.82 (s, 3H). Compound 105: ¹H NMR (400 MHz, CDCl3) δ 11.65-11.65 (1H, m), 9.31 (1H, s), 9.10 (1H, s), 7.49 (1H, s), 7.46-7.36 (1H, m), 7.05 (2H, dd, J=8.0, 8.0 Hz), 3.34-3.24 (1H, m), 3.19 (1H, d, J=4.0 Hz), 2.52 (3H, s), 2.49-2.39 (1H, m), 1.78-1.68 (1H, m), 1.42-1.32 (1H, m), 1.07 (3H, s), 0.80 (3H, s). Compound 106: ¹H NMR (400 MHz, CDCl3) δ 9.34 (s, 1H), 9.24 (s, 1H), 8.27 (dd, J=5.5, 5.5 Hz, 1H), 7.50 (s, 1H), 7.46-7.37 (m, 1H), 7.06 (dd, J=8.0, 8.0 Hz, 2H), 4.70-4.63 (m, 3H), 4.49 (d, J=6.7 Hz, 2H), 3.96 (d, J=5.9 Hz, 2H), 3.23-3.13 (m, 2H), 2.54-2.44 (m, 1H), 1.82-1.73 (m, 1H), 1.46-1.37 (m, 1H), 1.09 (s, 3H), 0.79 (s, 3H). Compound 107: ¹H NMR (400 MHz, CDCl3) δ 9.04 (d, J=5.1 Hz, 1H), 8.58 (dd, J=6.0, 6.0 Hz, 1H), 8.01 (d, J=5.1 Hz, 1H), 7.46 (s, 1H), 7.44-7.35 (m, 1H), 7.04 (dd, J=8.0, 8.0 Hz, 2H), 3.85-3.79 (m, 2H), 3.69-3.52 (m, 2H), 3.22-3.07 (m, 3H), 2.51-2.41 (m, 1H), 1.91-1.82 (m, 1H), 1.42-1.34 (m, 1H), 1.13 (s, 3H), 0.88 (s, 3H). Compound 112: ¹H NMR (400 MHz, CDCl3) δ 8.82 (s, 1H), 8.15-8.07 (m, 1H), 7.71 (dd, J=8.0, 8.0 Hz, 1H), 7.47 (s, 1H), 7.44-7.34 (m, 2H), 7.05 (dd, J=8.0, 8.0 Hz, 2H), 5.02 (s, 1H), 4.27 (dd, J=6.0, 16.3 Hz, 1H), 4.16 (dd, J=5.3, 16.2 Hz, 1H), 3.36-3.27 (m, 1H), 3.12 (d, J=4.0 Hz, 1H), 2.44-2.34 (m, 1H), 1.62-1.56 (m, 1H), 1.33-1.17 (m, 1H), 0.96 (s, 3H), 0.66 (s, 3H). Compound 114: 1H NMR (400 MHz, CDCl3) δ 8.91 (d, J=5.2 Hz, 1H), 8.42 (dd, J=5.4, 5.4 Hz, 1H), 8.07 (d, J=5.3 Hz, 1H), 7.49 (s, 1H), 7.46-7.37 (m, 1H), 7.05 (dd, J=8.0, 8.0 Hz, 2H), 4.12-4.06 (m, 1H), 3.72 (ddd, J=3.2, 6.7, 13.9 Hz, 1H), 3.45-3.28 (m, 2H), 3.18 (d, J=4.1 Hz, 1H), 2.53-2.46 (m, 2H), 1.78-1.69 (m, 1H), 1.44-1.36 (m, 1H), 1.28 (d, J=6.3 Hz, 3H), 1.16 (s, 3H), 0.72 (s, 3H). Compound 115: ¹H NMR (400 MHz, CDCl3) δ 8.91 (d, J=5.3 Hz, 1H), 8.41 (dd, J=5.5, 5.5 Hz, 1H), 8.08 (d, J=5.3 Hz, 1H), 7.49 (s, 1H), 7.46-7.37 (m, 1H), 7.05 (dd, J=8.1, 8.1 Hz, 2H), 4.13-4.06 (m, 1H), 3.72 (ddd, J=3.1, 6.8, 14.0 Hz, 1H), 3.44-3.28 (m, 2H), 3.18 (d, J=4.1 Hz, 1H), 2.50-2.47 (m, 2H), 1.79-1.70 (m, 1H), 1.44-1.36 (m, 1H), 1.27 (d, J=6.4 Hz, 3H), 1.17 (s, 3H), 0.72 (s, 3H). Compound 116: ¹H NMR (400 MHz, CDCl3) δ 7.90 (s, 1H), 7.72-7.60 (m, 2H), 7.46-7.37 (m, 2H), 7.17 (d, J=7.6 Hz, 1H), 7.04 (dd, J=8.0, 8.0 Hz, 2H), 4.68-4.54 (m, 2H), 4.13 (d, J=5.7 Hz, 2H), 3.56 (dd, J=6.0, 6.0 Hz, 1H), 3.24-3.11 (m, 2H), 2.50-2.40 (m, 1H), 1.71-1.62 (m, 1H), 1.58 (s, 2H), 1.39-1.23 (m, 1H), 1.08 (s, 3H), 0.70 (s, 3H). Compound 118: ¹H NMR (400 MHz, CDCl3) δ 9.02 (s, 1H), 8.82 (s, 1H), 7.62 (s, 1H), 7.48 (s, 1H), 7.45-7.36 (m, 1H), 7.05 (dd, J=8.0, 8.0 Hz, 2H), 3.30 (ddd, J=4.0, 10.5, 13.1 Hz, 1H), 3.17 (d, J=4.1 Hz, 1H), 2.60 (s, 3H), 2.56-2.42 (m, 1H), 1.78-1.70 (m, 1H), 1.42-1.34 (m, 1H), 1.13 (s, 3H), 0.80 (s, 3H). Compound 120: ¹H NMR (400 MHz, CDCl3) δ 9.03 (d, J=16.6 Hz, 2H), 8.17 (s, 1H), 7.47 (s, 1H), 7.44-7.36 (m, 1H), 7.04 (dd, J=8.0, 8.0 Hz, 2H), 3.28 (ddd, J=4.1, 10.5, 13.1 Hz, 1H), 3.16 (d, J=4.2 Hz, 1H), 2.56 (s, 3H), 2.50-2.40 (m, 1H), 1.77-1.69 (m, 1H), 1.41-1.33 (m, 1H), 1.11 (s, 3H), 0.80 (s, 3H). Compound 137: ¹H NMR (CDCl3, 400 MHz): δ 8.08-8.02 (m, 1H), 7.99-7.89 (m, 2H), 7.49 (s, 1H), 7.46-7.37 (m, 1H), 7.10-7.01 (m, 2H), 3.82-3.72 (m, 4H), 3.43-3.35 (m, 4H), 3.38-3.29 (M, 1H), 3.18 (d, J=4.0 Hz, 1H), 2.54-2.42 (m, 1H), 1.77-1.67 (m, 1H), 1.43-1.34 (m, 1H), 1.12 (s, 3H), 0.73 (s, 3H). Compound 181: ¹H NMR (CDCl3, 400 MHz): δ 8.72 (d, J=5.2 Hz, 1H), 8.67 (s, 1H), 7.95 (s, 1H), 7.92 (d, J=5.2 Hz, 1H), 7.50 (s, 1H), 7.47-7.38 (m, 1H), 7.19 (s, 1H), 7.10-7.02 (m, 2H), 3.38-3.24 (m, 1H), 3.19 (d, J=4.1 Hz, 1H), 2.58-2.45 (m, 1H), 1.80-1.69 (m, 1H), 1.47-1.35 (m, 1H), 1.23 (s, 3H), 0.77 (s, 3H). Compound 196: ¹H NMR (400 MHz, CDCl₃): δ 9.34 (s, 1H), 9.17 (s, 1H), 7.71 (s, 1H), 7.50 (t, J=1.2 Hz, 1H), 7.44 (tt, J=6.3, 8.4 Hz, 1H), 7.09-7.04 (m, 2H), 3.41 (ddd, J=4.0, 10.6, 13.1 Hz, 1H), 3.19 (d, J=4.1 Hz, 1H), 2.50 (tdd, J=4.3, 10.6, 12.6 Hz, 1H), 1.78 (ddd, J=4.1, 9.1, 13.1 Hz, 1H), 1.65 (s, 6H), 1.40 (ddd, J=3.9, 9.1, 12.7 Hz, 1H), 1.16 (s, 3H), 0.82 (s, 3H). Compound 203: ¹H NMR (CDCl3, 400 MHz): δ 12.08 (br. s, 1H), 9.31 (s, 1H), 9.07 (s, 1H), 7.50 (s, 1H), 7.47-7.37 (m, 1H), 7.10-7.02 (m, 2H), 3.46-3.21 (m, 2H), 3.19 (d, J=4.0 Hz, 1H), 2.50-2.38 (m, 1H), 1.70 (s, 6H), 1.39-1.29 (m, 1H), 1.06 (s, 3H), 0.80 (s, 3H). Compound 204: ¹H NMR (CDCl3, 400 MHz): δ 9.58 (br. s, 1H), 8.77 (br. s, 1H), 8.42 (s, 1H), 8.26 (s, 1H), 7.51 (s, 1H), 7.48-7.38 (m, 1H), 7.10-7.02 (m, 2H), 4.00 (br. s, 1H), 3.82-3.62 (m, 3H), 3.43-3.30 (m, 1H), 3.18 (d, J=4.0 Hz, 1H), 2.99-2.87 (m, 1H), 2.56-2.44 (m, 1H), 1.88-1.77 (m, 1H), 1.50-1.39 (m, 1H), 1.14 (s, 3H), 0.70 (s, 3H). Compound 211: ¹H NMR (CDCl3, 400 MHz): δ 7.67 (d, J=8.9 Hz, 1H), 7.58-7.48 (m, 3H), 7.46-7.37 (m, 1H), 7.18 (dd, J=9.0, 7.2 Hz, 1H), 7.10-7.02 (m, 2H), 7.02-6.96 (m, 1H), 3.17 (d, J=4.1 Hz, 1H), 2.73 (br. s, 1H), 2.51-2.39 (m, 1H), 2.28 (br. s, 1H), 1.50-1.39 (m, 1H), 1.28 (br. s, 3H), 1.04 (s, 3H). Compound 212: ¹H NMR (CDCl3, 400 MHz): δ 9.13 (s, 1H), 8.84 (d, J=5.2 Hz, 1H), 7.97 (d, J=5.2 Hz, 1H), 7.51 (s, 1H), 7.47-7.38 (m, 1H), 7.11-7.03 (m, 2H), 3.35-3.25 (m, 1H), 3.21 (d, J=4.0 Hz, 1H), 2.57 (s, 3H), 2.56-2.46 (M, 1H), 1.83-1.72 (m, 1H), 1.48-1.38 (m, 1H), 1.21 (s, 3H), 0.77 (s, 3H). Compound 267: ¹H NMR (CDCl₃, 300 MHz): δ 9.02 (s, 1H), 8.69 (d, J=2.1 Hz, 1H), 7.50 (t, J=1.3 Hz, 1H), 7.41 (tt, J=8.5, 6.3 Hz, 1H), 7.01-7.09 (m, 2H), 3.19 (d, J=4.2, 1H), 3.14 (ddd, J=14.5, 10.6, 4.2 Hz, 1H), 2.56 (s, 3H), 2.39-2.51 (m, 1H), 1.95-2.04 (m, 1H), 1.42 (ddd, J=13.0, 9.3, 4.0 Hz, 1H), 1.25 (s, 3H), 1.02 (d, J=2.7 Hz, 3H). Compound 293: ¹H NMR (CDCl₃, 400 MHz): δ 8.66 (d, J=2.1 Hz, 1H), 8.47 (d, J=2.6 Hz, 1H), 7.49 (s, 1H), 7.45-7.37 (m, 1H), 7.09-7.01 (m, 2H), 6.53 (d, J=2.7 Hz, 1H), 4.84 (s, 2H), 3.18 (d, J=4.1 Hz, 1H), 3.17-3.07 (m, 1H), 2.51-2.40 (m, 1H), 2.05 (br. s, 1H), 2.05-1.94 (m, 1H), 1.46-1.36 (m, 1H), 1.26 (s, 3H), 1.02 (d, J=2.7 Hz, 3H). Compound 300: ¹H NMR (d₆-DMSO, 400 MHz): δ 8.89 (d, J=5.2 Hz, 1H), 8.60 (d, J=2.6 Hz, 1H), 7.84 (s, 1H), 7.70 (d, J=5.2 Hz, 1H), 7.67-7.58 (m, 1H), 7.52 (br. s, 1H), 7.35-7.26 (m, 2H), 7.00 (br. s, 1H), 6.52 (d, J=2.6 Hz, 1H), 3.53 (s, 2H), 3.28-3.18 (M, 1H), 2.49-2.40 (M, 1H), 1.67-1.57 (m, 1H), 1.32-1.21 (m, 2H), 1.11 (s, 3H), 0.76 (s, 3H). Compound 321: ¹H NMR (d₆-DMSO, 400 MHz): δ 14.67 (br. s, 1H), 8.09-8.03 (m, 2H), 7.82 (s, 1H), 7.80-7.74 (m, 1H), 7.67-7.58 (m, 1H), 7.35-7.27 (m, 2H), 4.70 (s, 2H), 3.83-3.69 (m, 1H), 3.31 (M, 1H), 3.19 (s, 3H), 2.47-2.35 (m, 1H), 1.53-1.41 (m, 1H), 1.32-1.21 (m, 1H), 1.04 (s, 3H), 0.65 (s, 3H). Compound 334: ¹H NMR (CDCl3, 400 MHz): δ 8.36 (d, J=5.1 Hz, 1H), 7.44 (s, 1H), 7.43-7.36 (M, 1H), 7.13 (d, J=5.1 Hz, 1H), 7.09-7.00 (m, 2H), 4.56 (d, J=13.2 Hz, 2H), 4.09-4.00 (m, 1H), 3.80-3.73 (m, 1H), 3.74-3.63 (m, 3H), 3.22-3.07 (m, 3H), 2.97-2.88 (m, 1H), 2.47-2.36 (m, 1H), 2.01 (br. s, 1H), 1.68-1.59 (m, 1H), 1.37-1.28 (m, 1H), 1.14 (s, 3H), 0.75 (s, 3H). Compound 340: ¹H NMR (d6-DMSO, 400 MHz): δ 14.64 (br. s, 1H), 8.08-8.02 (m, 2H), 7.82 (s, 1H), 7.79-7.73 (m, 1H), 7.67-7.57 (m, 1H), 7.35-7.27 (m, 2H), 7.03 (br. s, 1H), 5.32 (br. s, 1H), 3.74 (br. s, 1H), 3.32-3.28 (M, 1H), 2.47-2.36 (m, 1H), 1.54-1.43 (m, 1H), 1.33-1.21 (m, 1H), 1.03 (s, 3H), 0.66 (s, 3H). Compound 348: ¹H NMR (CDCl3, 400 MHz): δ 8.82 (d, J=5.1 Hz, 1H), 8.58 (d, J=2.67 Hz, 1H), 7.87 (d, J=5.2 Hz, 1H), 7.50 (s, 1H), 7.48-7.38 (m, 1H), 7.11-7.02 (m, 2H), 6.51 (d, J=2.6 Hz, 1H), 5.15 (q, J=6.6 Hz, 1H), 3.36-3.24 (m, 1H), 3.19 (d, J=4.1 Hz, 1H), 2.56-2.45 (m, 1H), 1.81-1.72 (m, 1H), 1.62 (d, J=6.6 Hz, 3H), 1.47-1.35 (m, 1H), 1.20 (s, 3H), 0.77 (s, 3H). Compound 356: ¹H NMR (CDCl3, 400 MHz): δ 8.69 (d, J=5.2 Hz, 1H), 7.77 (d, J=5.2 Hz, 1H), 7.47 (s, 1H), 7.46-7.37 (m, 1H), 7.10-7.01 (m, 2H), 4.15-4.06 (m, 2H), 3.65-3.55 (m, 2H), 3.39-3.28 (m, 1H), 3.22-3.12 (m, 2H), 2.52-2.40 (m, 1H), 2.13-1.94 (m, 4H), 1.71-1.61 (m, 1H), 1.41-1.32 (m, 1H), 1.15 (s, 3H), 0.73 (s, 3H). Compound 369: ¹H NMR (400 MHz, CDCl₃) δ 9.30 (d, J=0.4 Hz, 1H), 9.22 (d, J=0.4 Hz, 1H), 8.02 (s, 1H), 7.51 (t, J=1.3 Hz, 1H), 7.42 (tt, J=6.3, 8.5 Hz, 1H), 7.10-7.03 (m, 2H), 4.35 (s, 2H), 3.38 (ddd, J=4.1, 10.6, 13.0 Hz, 1H), 3.21 (d, J=4.2 Hz, 1H), 3.07 (s, 3H), 2.55-2.46 (m, 1H), 1.80 (ddd, J=4.1, 9.1, 13.1 Hz, 1H), 1.42 (ddd, J=3.8, 9.1, 12.8 Hz, 1H), 1.17 (s, 3H), 0.83 (s, 3H). LCMS (m/z) ES⁺524.2 [M+1]⁺. Compound 373: ¹H NMR (d6-DMSO, 400 MHz): δ 9.61-9.51 (m, 1H), 9.06 (d, J=5.2 Hz, 1H), 8.90 (dd, J=8.2, 2.1 Hz, 1H), 8.25 (br. s, 1H), 8.22 (dd, J=8.2, 0.8 Hz, 1H), 7.88-7.84 (m, 2H), 7.77 (s, 1H), 7.67-7.57 (m, 1H), 7.36-7.27 (m, 2H), 3.37-3.24 (M, 1H), 2.54-2.44 (M, 1H), 1.73-1.62 (m, 1H), 1.37-1.26 (m, 1H), 1.15 (s, 3H), 0.79 (s, 3H). Compound 380: ¹H NMR (d6-DMSO, 400 MHz): δ 9.29 (s, 1H), 9.05 (s, 1H), 8.40 (s, 1H), 7.86 (s, 1H), 7.67-7.58 (m, 1H), 7.36-7.27 (m, 2H), 4.17-4.12 (m, 2H), 3.35-3.31 (M, 1H), 3.26-3.16 (m, 1H), 2.49-2.42 (M, 1H), 1.72-1.62 (m, 1H), 1.35-1.24 (m, 1H), 1.08 (s, 3H), 0.80 (s, 3H). Compound 386: ¹H NMR (d6-DMSO, 400 MHz): δ 11.81 (br. s, 1H), 9.05-9.01 (m, 1H), 7.88-7.82 (m, 2H), 7.67-7.58 (m, 1H), 7.55 (d, J=6.8 Hz, 1H), 7.35 (s, 1H), 7.34-7.27 (m, 2H), 7.11 (d, J=6.8 Hz, 1H), 3.28-3.17 (m, 1H), 2.55-2.43 (M, 2H), 1.70-1.59 (m, 1H), 1.35-1.25 (m, 1H), 1.12 (s, 3H), 0.76 (s, 3H). Compound 393: ¹H NMR (d6-DMSO, 400 MHz): δ 9.35 (d, J=0.4 Hz, 1H), 9.01 (d, J=0.4 Hz, 1H), 8.69 (dd, J=5.1, 0.8 Hz, 1H), 8.44-8.42 (m, 1H), 8.00 (dd, J=5.1, 1.7 Hz, 1H), 7.86 (s, 1H), 7.67-7.56 (m, 1H), 7.35-7.27 (m, 2H), 3.35-3.28 (M, 2H), 3.29-3.20 (M, 1H), 1.77-1.66 (m, 1H), 1.51 (s, 6H), 1.37-1.27 (m, 1H), 1.24 (br. s, 1H), 1.12 (s, 3H), 0.83 (s, 3H). Compound 395: ¹H NMR (d₆-DMSO, 400 MHz): δ 11.95 (br. s, 1H), 9.12 (s, 1H), 8.77 (s, 1H), 8.33-8.22 (m, 2H), 7.83 (s, 1H), 7.67-7.60 (m, 1H), 7.35-7.26 (m, 2H), 6.52 (dd, J=9.6, 0.7 Hz, 1H), 3.33-3.29 (M, 1H), 3.27-3.16 (m, 1H), 2.48-2.39 (M, 1H), 1.69-1.58 (m, 1H), 1.33-1.21 (m, 1H), 1.08 (s, 3H), 0.77 (s, 3H). Compound 402: ¹H NMR (d₆-DMSO, 400 MHz): δ 9.26 (d, J=0.3 Hz, 1H), 8.97 (dd, J=2.5, 0.7 Hz, 1H), 8.89 (d, J=0.3 Hz, 1H), 8.51 (dd, J=8.7, 2.5 Hz, 1H), 7.84 (s, 1H), 7.67-7.57 (m, 1H), 7.51 (br. s, 1H), 7.35-7.27 (m, 2H), 7.23 (br. s, 1H), 7.09 (dd, J=8.7, 0.7 Hz, 1H), 4.76 (s, 2H), 3.29-3.21 (M, 1H), 2.49-2.40 (M, 1H), 1.72-1.61 (m, 1H), 1.34-1.20 (m, 2H), 1.11 (s, 3H), 0.79 (s, 3H). Compound 406: H NMR (CDCl₃, 400 MHz): δ 8.92 (s, 1H), 8.72 (s, 1H), 8.12 (d, J=0.6 Hz, 1H), 8.02 (d, J=0.5 Hz, 1H), 7.48 (t, J=1.3 Hz, 1H), 7.46-7.37 (m, 1H), 7.10-7.01 (m, 2H), 4.16 (s, 2H), 3.68 (s, 1H), 3.86-3.27 (m, 1H), 3.18 (d, J=4.0 Hz, 1H), 2.53-2.41 (m, 1H), 1.80-1.69 (m, 1H), 1.45-1.33 (m, 1H), 1.24 (s, 6H), 1.15 (s, 3H), 0.82 (s, 3H).

Example 10 In Vitro RORc Ligand Binding Assay

This assay was used to determine a compound's potency in inhibiting activity of RORc by determining, Ki_(app), IC₅₀, or percent inhibition values. Consumables used in this Example are shown in Table 2 below.

TABLE 2 Consumable Supplier and product code GFB Unifilter plates Perkin Elmer 6005177 3-[(3- Sigma C5070 Cholamidopropyl)dimethyl- ammonio]-1-propane- sulfonate (CHAPS) 96-well polypropylene U- Nunc 267245 bottom assay plate HEPES buffer, 1M Sigma H3375 Magnesium chloride (MgCl₂) Sigma M8266 D,L-Dithiothreitol (DTT) Sigma D0632 Sodium chloride (NaCl) Sigma 71382 Bovine serum albumin (BSA) Sigma A7030 [lyophilized powder, ≥98% (agarose gel electrophoresis), Essentially fatty acid free, essentially globulin free] 25-hydroxycholesterol Sigma H1015 25-[26,27-³H]hydroxy- Perkin Elmer NET674250UC cholesterol American Radiolabeled Chemicals ART0766 RORc ligand binding domain Genentech (e.g., PUR 28048), expressed in E. coli Plate seals Perkin Elmer 6005185 Microscint 0 Perkin Elmer 6013611 Filter Plate Preparation

On day of the assay, 100 uL of 0.05% CHAPS (in deionized H₂O) was added to all wells of the GFB Unifilter plate and allowed soak for 1 h. A wash buffer of 50 mM HEPES (pH 7.4), 150 mM NaCl, and 5 mM MgCl₂ was prepared to wash the filter plate. To prepare an assay buffer, BSA was added to the wash buffer to reach 0.01% and DTT was added to reach 1 mM.

Compounds

For IC₅₀ mode, 10 mM compound stocks were serially diluted in DMSO with DMSO to give 20× required final concentration in DMSO (15 uL compound+30 uL DMSO). The 20× compound stocks were diluted in DMSO with Assay Buffer 4-fold to reach 5× the final test concentration in 25% DMSO (10 uL compound+30 uL Assay Buffer). Solutions were mixed by aspiration several times with a pipette set on 50 uL volume. For the assay, 10 uL of 5× compound stock solutions in 25% DMSO were added to the assay plate in duplicate.

For two point screening, 10 mM stock compound solutions were diluted in DMSO to obtain 200 uM (20× the high test concentration) and then diluted 10-fold further to reach 20 uM (20× the low test concentration). The 20× stocks were diluted 4-fold with Assay Buffer (10 uL compound+30 uL Assay Buffer) to reach 5× the test concentrations (50 uM and 5 uM) and 10 uL were added to two assay plates for the duplicate wells. With each concentration tested on 2 plates, each set of 80 compounds used 4 assay plates (1 uM and 10 uM, with n=2).

Nonspecific Binding (NSB) Samples, Total Binding (TB) Samples and No Receptor (No R) Samples

25-hydroxycholesterol (1 uM) was used to determine the level of NSB signal is prepared in DMSO as for compounds above, then diluted in Assay Buffer to give a final concentration of 5 uM. For 25-hydroxycholesterol in 25% DMSO/75% Assay Buffer; 10 uL per well was used for NSB samples. Wells for Total Binding and No Receptor sample determination contained 10 uL of 25% DMSO/75% Assay Buffer per well.

Radioligand (25-[³H]hydroxycholesterol) Preparation

25-[³H]hydroxycholesterol was diluted in Assay Buffer to obtain 15 nM and vortex to mix. Add 20 uL to all wells to reach 6 nM final concentration in the assay.

Receptor Preparation

The optimal concentration for RORc receptor was found to be 0.6 ug/mL. Stock receptor solution was diluted in assay buffer to obtain 1.5 ug/mL in Assay Buffer. 20 uL was added to all wells. For No Receptor samples, 20 uL Assay Buffer was substituted for receptor solution.

Sample addition to Plates and Incubation

Assay plates were 96-well polypropylene V-bottom plates. 10 uL of 5× compound in 25% DMSO/75% Assay Buffer was added to Test wells. 10 uL of 25% DMSO/75% Assay Buffer was added to Total Binding or No Receptor wells. 10 uL of 5 uM 25-hydroxycholesterol in 25% DMSO/75% Assay Buffer was added to NSB wells. 20 uL of 15 nM 25-[³H]hydroxycholesterol prepared in Assay Buffer was added to all wells. 20 uL of 1.5 ug/mL RORc receptor was added to wells (or 40 uL Assay Buffer to No R wells). Following addition to the wells, the plates were incubated 3 h at 25° C.

Filtration

Using a Packard Filtermate Harvester, the filter plate were washed 4 times following transfer of the incubated samples. Plates were dry-filtered completely (2 h at 50° C. or overnight at room temperature). 50 uL Microscint 0 was added to all wells and read on Topcount protocol Inverted.

Final Concentrations

Final concentrations were as follows: 50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl₂; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[³H]hydroxycholesterol. For NSB wells, 1 uM 25-hydroxycholesterol was also present.

Example 11: RORc Coactivator Peptide Binding Assay

Assays were carried out in 16-microL reaction volumes in black 384 Plus F Proxiplates (Perkin-Elmer 6008269). All assay components except test ligand were mixed in coregulator buffer D (Invitrogen PV4420) containing 5 mM DTT and added to the plate at twice their final concentrations in a volume of 8 microL. Test ligands at 2× the final concentration were then added to the wells in 8 □L of coregulator buffer D containing 5 mM DTT and 4% DMSO. Final incubations contained 1× coregulator buffer D, 5 mM DTT, test ligand, 2% DMSO, 50 nM biotinyl-CPSSHSSLTERKHKILHRLLQEGSPS (American Peptide Company; Vista, Calif.), 2 nM Europium anti-GST (Cisbio 61GSTKLB), 12.5 nM streptavidin-D2 (Cisbio 610SADAB), 50 mM KF, and 10 nM of bacterially-expressed human RORc ligand binding domain protein containing an N-terminal 6×His-GST-tag and residues 262-507 of Accession NP_005051. Ten test ligand concentrations were tested in duplicate. After the reaction plates were incubated for 3 h in the dark at room temperature (22-23° C.), the plate was read on an EnVision plate reader (PerkinElmer) following the Europium/D2 HTRF protocol (ex 320, em 615 and 665, 100 Os lag time, 100 flashes, 500 s window). The time-resolved FRET signal at 665 nm was divided by that at 615 nm to generate the signal ratio of each well. The signal ratio of wells containing RORc and peptide but no test ligand were averaged and set to 0% Effect while the signal ratios of the blank wells containing coactivator peptide but no RORc were averaged and set to −100% Effect. RORc exhibits a basal (constitutive) signal in this assay and test ligands can increase or decrease the signal ratio relative to this basal signal level. RORc agonists increase the signal ratio in this assay and result in a positive % Effect value. Inverse agonists decrease the signal ratio, and result in a negative % Effect value. The EC₅₀ value is the concentration of test compound that provides half-maximal effect (increased or decreased assay signal) and is calculated by Genedata Screener® software (Genedata; Basel, Switzerland) using the following equation: % Effect=S ₀+{(S _(inf) −S ₀)/[1+(10^(log EC) ₅₀/10^(c))^(a)]} where S₀ equals the activity level at zero concentration of test compound, S_(inf) is the activity level at infinite concentration of test compound, EC₅₀ is the concentration at which the activity reaches 50% of the maximal effect, c is the concentration in logarithmic units corresponding to the values on the x-axis of the dose-response curve plot, and n is the Hill coefficient (the slope of the curve at the EC₅₀).

Example 12: Arthritis Mouse Model

8 to 10-week old male DBA/1 (DBA/1OlaHsd, Harlan Laboratories) mice are housed in a specific pathogen free (SPF) animal facility. Arthritis is induced by two injections of collagen subcutaneously in the base of the tail. The initial injection (on day 0) uses bovine type II collagen (2 mg/ml from Chondrex, Redmond, Wash.) emulsified in equal volume of CFA containing 4 mg/ml of M. tuberculosis (Chondrex). The CII booster injection on Day 29 is emulsified in incomplete Freund's adjuvant (IFA). Each animal receives 0.1 ml of emulsion by subcutaneous/intradermal injection in the tail 2 to 3 cm from the body of the mouse. The booster injection site is in the vicinity of but different from the initial injection site and closer to the body of the animal. OR-1050 was formulated in HRC-6 as above. On weekdays, the animals receive two doses (a.m. and p.m.) of HRC-6 or 50 mg/kg OR-1050 p.o. (2.5 mls/kg). On weekends, a single dose of 100 mg/kg is administered (5 mls/kg).

The mice are observed daily for clinical symptoms of CIA based on the following qualitative scale. Each paw was examined individually and scored. Grade 0, normal; grade 1, mild but definite redness and swelling of the ankle or wrist, or apparent redness and swelling limited to individual digits, regardless of the number of affected digits; grade 2, moderate redness and swelling of ankle or wrist; grade 3, severe redness and swelling of the entire paw including digits; grade 4, maximally inflamed limb with involvement of multiple joints. To estimate cumulative disease severity for each animal, an area under the curve score is calculated for each animal by totaling the sum of the daily hind paw measurements betweens days 24 and 48.

Example 13: Muscular Sclerosis Mouse Model I

Experiments are conducted on female mice aged 4-6 weeks belong to the C57BL/6 strain weighing 17-20 g. Experimental autoimmune encephalomyelitis (EAE) is actively induced using 95% pure synthetic myelin oligodendrocyte glycoprotein peptide 35-55 (MOG₃₅₋₅₅) (Invitrogen). Each mouse is anesthetized and receives 200 ug of MOG₃₅₋₅₅ peptide and 15 ug of Saponin extract from Quilija bark emulsified in 100 uL of phosphate-buffered saline. A 25 uL volume is injected subcutaneously over four flank areas. Mice are also intraperitoneally injected with 200 ng of pertussis toxin in 200 uL of PBS. A second, identical injection of pertussis toxin is given after 48 h.

A compound of the invention is administered at selected doses. Control animals receive 25 uL of DMSO. Daily treatment extends from day 26 to day 36 post-immunization. Clinical scores are obtained daily from day 0 post-immunization until day 60. Clinical signs are scored using the following protocol: 0, no detectable signs; 0.5, distal tail limpness, hunched appearance and quiet demeanor; 1, completely limp tail; 1.5, limp tail and hindlimb weakness (unsteady gait and poor grip with hind limbs); 2, unilateral partial hind limb paralysis; 2.5, bilateral hind limb paralysis; 3, complete bilateral hindlimb paralysis; 3.5, complete hindlimb paralysis and unilateral forelimb paralysis; 4, total paralysis of hind limbs and forelimbs (Eugster et al., Eur J Immunol 2001, 31, 2302-2312).

Inflammation and demyelination may be assessed by histology on sections from the CNS of EAE mice. Mice are sacrificed after 30 or 60 days and whole spinal cords are removed and placed in 0.32 M sucrose solution at 4° C. overnight. Tissues are prepared and sectioned. Luxol fast blue stain is used to observe areas of demyelination. Haematoxylin and eosin staining is used to highlight areas of inflammation by darkly staining the nuclei of mononuclear cells. Immune cells stained with H&E are counted in a blinded manner under a light microscope. Sections are separated into gray and white matter and each sector is counted manually before being combined to give a total for the section. T cells are immunolabeled with anti-CD3+ monoclonal antibody. After washing, sections are incubated with goat anti-rat HRP secondary antibody. Sections are then washed and counterstained with methyl green. Splenocytes isolated from mice at 30 and 60 days post-immunization are treated with lysis buffer to remove red blood cells. Cells are then re-suspended in PBS and counted. Cells at a density of about 3×10⁶ cells/mL are incubated overnight with 20 ug/mL of MOG peptide. Supernatants from stimulated cells are assayed for IFNgamma protein levels using an appropriate mouse IFN-gamma immunoassay system.

Example 14: Muscular Sclerosis Mouse Model II

In this model, female rodents are anesthetized with isoflurane and injected with Freund's Incomplete Adjuvant containing 1 mg/mL neuronal antigen (e.g. myelin basic protein, myelin oligodendrocyte glycoprotein, proteolipid protein) and 4 mg/mL mycobacterium tuberculosis at two sites on the back on day 0 of this study. A compound of interest is then dosed daily in a sub-cutaneous, intraperitoneally, or oral manner from day 0 until the end of study at an efficacious dose. Daily observations of degree of paralysis are taken as measures of efficacy.

Example 15: Psoriasis Mouse Model I

The severe, combined immunodeficient (SCID) mouse model can be used to evaluate the efficacy of compounds for treating psoriasis in humans (Boehncke, Ernst Schering Res Found Workshop 2005, 50, 213-34; and Bhagavathula et al., J Pharmacol Expt'l Therapeutics 2008, 324(3), 938-947). Briefly, SCID mice are used as tissue recipients. One biopsy for each normal or psoriatic volunteer (human) is transplanted onto the dorsal surface of a recipient mouse. Treatment is initiated 1 to 2 weeks after transplantation. Animals with the human skin transplants are divided into treatment groups. Animals are treated twice daily for 14 days. At the end of treatment, animals are photographed and then euthanized. The transplanted human tissue along with the surrounding mouse skin is surgically removed and fixed in 10% formalin and samples obtained for microscopy. Epidermal thickness is measured. Tissue sections are stained with an antibody to the proliferation-associated antigen Ki-67 and with an anti-human CD3.sup.+ monoclonal antibody to detect human T lymphocytes in the transplanted tissue. Sections are also probed with antibodies to c-myc and beta-catenin. A positive response to treatment is reflected by a reduction in the average epiderma thickness of the psoriatic skin transplants. A positive response is also associated with reduced expression of Ki-67 in keratinocytes.

Example 16: Psoriasis Mouse Model II

Using the Imidquimod model of skin inflammation (Fits et al, Journal of Immunology, 2009, 182: 5836-5845), 10-12 week old BALB/c, Il17c+/+ or Il17c−/−, or Il17re+/+ or Il17re−/− mice were administered 50 mg Aldara cream (5% Imidquimod in Graceway, 3M) in the shaved back and right ear daily for 5 days. Clinical scoring and ear thickness measurements were performed daily. Scoring was based upon the manifestation of psoriatic symptoms, such as erythema, scaling and thickness: 0, No disease. 1, Very mild erythema with very mild thickening and scaling involving a small area. 2, Mild erythema with mild thickening and scaling involving a small area. 3, Moderate erythema with moderate thickening and scaling (irregular and patchy) involving a small area (<25%). 4, Severe erythema with marked thickening and scaling (irregular and patchy) involving a moderate area (25-50%). 5, Severe erythema with marked thickening and scaling (irregular and patchy) involving a large area (>50%). Ear and back tissue were harvested on day 5 for histological evaluation. Efficacy of compounds is compared in the imiquimod (IMQ) mouse model of psoriasis. Balb/c mice (10 males/group) received daily topical IMQ (5% cream) on shaved back and right ear for 5 days as described above. Animals received oral dose of a representative compound or DMF (45 or 90 mg-eq MMF/kg twice daily) or vehicle from Day −5 to Day +5. Erythema score is the primary outcome measure.

Example 16: Irritable Bowel Disease Mouse Model I

Effectiveness in treatment of inflammatory bowel disease may be evaluated as described by Jurjus et al., J Pharmaocol Toxicol Methods 2004, 50, 81-92; Villegas et al., Int'l Immunopharmacol 2003, 3, 1731-1741; and Murakami et al., Biochemical Pharmacol 2003, 66, 1253-1261. Briefly, female ICR mice are divided into treatment groups which are given either water (control), 5% DSS in tap water is given at the beginning of the experiment to induce colitis, or various concentrations of test compound. After administering test compound for 1 week, 5% DSS in tap water is also administered to the groups receiving test compound for 1 week. At the end of the experiment, all mice are sacrificed and the large intestine is removed. Colonic mucosa samples are obtained and homogenized. Proinflammatory mediators (e.g., IL-1alpha, IL-1beta, TNFalpha, PGE2, and PGF2alpha.) and protein concentrations are quantified. Each excised large intestine is histologically examined and the damage to the colon scored.

Example 17: Chronic Obstructive Pulmonary Disease Mouse Model

The cigarette smoke model of Martorana et al., Am J Respir Crit Care Med 2005, 172, 848-835; and Cavarra et al., Am J Respir Crit Care Med 2001, 164, 886-890 can be used for assessing efficacy in treating emphysema. Briefly, six-week old C57Bl/6J male mice are exposed either to room air or to the smoke of five cigarettes for 20 minutes. For the acute study, mice are divided into three groups of 40 animals each. These groups are then divided into four subgroups of 10 mice each as follows: (1) no treatment/air-exposed; (2) no treatment/smoke-exposed; (3) a first dose of test compound plus smoke-exposed; and (4) a second dose of test compound. In the first group, trolox equivalent antioxidant capacity is assessed at the end of the exposure in bronchoalveolar lavage fluid. In the second group, cytokines and chemokines are determined in bronchoalveolar lavage fluid using a commercial cytokine panel at 4 hours; and in the third group bronchoalveolar lavage fluid cell count is assessed at 24 hours.

In a chronic study, the mice are exposed to either room air or to the smoke of three cigarettes/day, for 5 days/week, for 7 months. Five groups of animals are used: (1) no treatment/air-exposed; (2) a first dose of a test compound plus air-exposed; (3) no treatment/smoke-exposed; (4) a second dose of the test compound plus smoke-exposed; and (5) the first dose of the test compound plus smoke exposed. Seven months after chronic exposure to room air or cigarette smoke, 5 to 12 animals from each group are sacrificed and the lungs fixed intratracheally with formalin. Lung volume is measured by water displacement. Lungs are stained. Assessment of emphysema includes mean linear intercept and internal surface area. The volume density of macrophages, marked immunohistochemically with anti-mouse Mac-3 monoclonal antibodies is determined by point counting. A mouse is considered to have goblet cell metaplasia when at least one or more midsize bronchi/lung showed a positive periodic acid-Schiff staining for the determination of desmosine, fresh lungs are homogenized, processed, and analyzed by high-pressure liquid chromatography.

Example 18: Asthma Mouse Model

A single inhaled allergen challenge can induce an acute increase in airway responsiveness in some individuals and animal models. However, repeated allergen inhalations have demonstrated more pronounced, consistent, and prolonged increases in airway responsiveness. This mouse model of long-term repeated inhalations of allergen has been used to study the long term effect of allergic diseases in the lung, and to delineate the cells, mechanisms, molecules, and mediators involved in the induction of airway hyperresponsiveness of lung in humans.

Crystalline OVA is obtained from Pierce Chem. Co. (Rockford, Ill.) aluminum potassium sulfate (alum) from Sigma Chem. Co. (St. Louis, Mo.), pyrogen-free distilled water from Baxter, Healthcare Corporation (Deerfield, Ill.), 0.9% sodium chloride (normal saline) from Lymphomed (Deerfield, Ill.) and Trappsol™ HPB-L100 (aqueous hydroxypropylbeta cyclodextrin; 45 wt/vol % aqueous solution) from Cyclodextrin Technologies Development, Inc. (Gainesville, Fla.). The OVA (500 ug/ml in normal saline) is mixed with equal volumes of 10% (wt/vol) alum in distilled water. The mixture (pH 6.5 using 10 N NaOH) after incubation for 60 minutes at room temperature is centrifuged at 750 g for 5 minutes; the pellet resuspended to the original volume in distilled water and used within one hour. The selective 5-lipoxtgenase inhibitor, Zileuton (N-[1-benzo[b]thien-2-ylethyl]-N-hydroxyurea; J. Pharmacol Exp Ther. 1991; 256: 929-937) is dissolved in Trappsol™ Histatek, Inc. (Seattle, Wash.) to provide the mast cell degranulation inhibitor, f-Met-Leu-Phe-Phe (“HK-X”).

Female BALB/c Once (6-8 wk of age) receive an i.p. injection of 0.2 ml (100 ug) of OVA with alum (J. Exp Med. 1996; 184: 1483-1494). Mice are anesthetized with 0.2 ml i.p. of ketamine (0.44 mg/ml)/xylazine (6.3 mg/ml) in normal saline before receiving an intranasal (i.n.) dose of 100 ug OVA in 0.05 ml normal saline and an i.n. dose of 50 ug OVA in 0.05 ml normal saline separately on different days. Two control groups are used: the first group receives normal saline with alum i.p. and normal saline without alum i.n.; and the second group receives OVA with alum i.p., OVA without alum i.n., and normal saline, alone.

The trachea and left lung (the right lung may be used for bronchoalveolar lavage (“BAL”) as described below) are obtained and fixed in 10% neutral formaldehyde solution at room temperature for about 15 h. After being embedded in paraffin, the tissues are cut into 5-um sections and processed with the different staining or immunolabling further. Discombe's eosinophil staining is used for counting the cell numbers with the counterstain of methylene blue. The eosinophil number per unit airway area (2,200 um²) is determined by morphometry (J. Pathol. 1992; 166: 395-404; Am Rev Respir Dis. 1993; 147:448-456). Fibrosis is identified with the Masson's trichrome staining. Airway mucus iss identified by the following staining method: methylene blue, hematoxylin and eosin, mucicarmine, alcian blue, and alcian blue/periodic acid-Schiff (PAS) reaction (Troyer, H., “Carbohydrates” in Principles and Techniques of Histochemistry, Little, Brown and Company, Boston, Mass., 1980: 89-121; Sheehan, D. C., et al., “Carbohydrates” in Theory and Practice of Histotechnology, Battle Press, Columbus, Ohio, 1980: 159-179) Mucin is stained with mucicarmine solution; metanil yellow counterstain is employed. Acidic mucin and sulfated mucosubstances are stained with alcian blue, pH 2.5; nuclear fast red counterstain is used. Neutral and acidic mucosubstances are identified by alcian blue, pH 2.5, and PAS reaction. The degree of mucus plugging of the airways (0.5-0.8 mm in diameter) is also assessed by morphometry. The percent occlusion of airway diameter by mucus iss classified on a semiquantitative scale from 0 to 4+. The histologic and morphometric analyses may be performed by individuals blinded to the protocol design.

On day 28, 24 hours after the last i.n. administration of either normal saline or OVA, pulmonary mechanics to intravenous infusion of methacholine may be determined in mice in vivo by a plethysmographic method as previously described (10, 1958; 192: 364-368; J. Appl. Physiol. 1988; 64: 2318-2323; J. Exp. Med. 1996; 184: 1483-1494).

After tying off the left lung at the mainstem bronchus, the right lung may be lavaged three times with 0.4 ml of normal saline. Bronchoalveolar lavage (BAL) fluid cells from a 0.05-ml aliquot of the pooled sample are counted using a hemocytometer and the remaining fluid centrifuged at 4° C. for 10 minutes at 200 g. The supernatant may be stored at 70.degree. C. until eicosanoid analysis is performed. After resuspension of the cell pellet in normal saline containing 10% bovine serum albumin (“BSA”), BAL cell smears are made on glass slides. To stain eosinophils, dried slides are stained with Discombe's diluting fluid (0.05% aqueous eosin and 5% acetone (vol/vol) in distilled water; J. Exp. Med. 1970; 131: 1271-1287) for 5-8 minutes, rinsed with water for 0.5 minutes, and counterstained with 0.07% methylene blue for 2 minutes.

While the present invention has been described with reference to the specific embodiments thereof, it should be understood by those skilled in the art that various changes may be made and equivalents may be substituted without departing from the true spirit and scope of the invention. In addition, many modifications may be made to adapt a particular situation, material, composition of matter, process, process step or steps, to the objective spirit and scope of the present invention. All such modifications are intended to be within the scope of the claims appended hereto. 

What is claimed is:
 1. A compound of formula I

or a pharmaceutical salt thereof, wherein: A is: a six membered hetereoaryl selected from: pyridinyl; pyrimidinyl; pyrazinyl; pyridazinyl; and triazinyl; m is: 0; 1; or 2; n is: 1; R¹ is: halo; R² is: hydrogen; or halo; R³ is: hydrogen; C₁₋₆alkyl; or halo; R⁴ is: C₁₋₆alkyl; oxo; hydroxy; C₁₋₆alkyoxy; C₁₋₆alkyoxycarbonyl; halo-C₁₋₆alkyl; cyano; or halo; R⁵ is: heteroaryl selected from pyridinyl, pyrimidinyl, pyrazinyl, pyridazinyl, oxadiazolyl, triazolyl, oxazolyl, tetrazolyl, imidazolyl, pyrazolyl, isoxazolyl, thiazolyl, isothiazolyl and thiadiazolyl, each of which may be unsubstituted or substituted once or twice with R^(a); heterocyclyl selected from azetidinyl, oxetanyl, pyrrolidinyl, imidazolidinyl, morpholinyl, 1-oxa-6-azaspiro[3.3]heptanyl, piperazinyl, piperidinyl, pyrrolidinyl, imidazolinidinyl, tetrahydropyranyl, tetrahydropyranyl, tetrahydrotriazinyl, thiomorpolinyl, 1,1-dioxo-thiomorpholinyl, and dihydropyridinyl, each of which may be unsubstituted or substituted once or twice with R^(a); cyano; —NR^(b)R^(c); —C₁₋₆alkylene-NR^(b)R^(c); —OR^(d); —C(O)NR^(e)R^(f); —SO₂NR^(e)R^(f); —C(O)OR^(g); or hydroxy-C₁₋₆alkyl; R^(a) is: C₁₋₆alkyl; C₁₋₆alkenyl; C₁₋₆alkynyl; amino; cyano; cyano-C₁₋₆alkyl; hydroxy; oxo; halo; halo-C₁₋₆alkyl; hydroxy-C₁₋₆alkyl; hydroxy-C₁₋₆alkoxy; hydroxy-C₁₋₆alkyl substituted with halo; hydroxy-C₁₋₆alkoxy substituted with halo; aminocarbonyl; aminocarbonyl-C₁₋₆alkyl; aminocarbonyl-C₁₋₆alkoxy; hydroxy-C₁₋₆alkylaminocarbonyl; C₁₋₆alkylcarbonyl; hydroxy-C₁₋₆alkylcarbonyl; C₃₋₆cycloalkyl which may be unsubstituted or substituted once with R^(h); C₁₋₆alkyoxycarbonyl; C₁₋₆alkylsulfonyl; C₁₋₆alkylsulfonyl-C₁₋₆alkyl; C₃₋₆cycloalkylsulfonyl; C₃₋₆cycloalkylsulfonyl-C₁₋₆alkyl; C₃₋₆cycloalkyl-C₁₋₆alkylsulfonyl; C₃₋₆cycloalkyl-C₁₋₆alkylsulfonyl-C₁₋₆alkyl; oxetanyl which may be unsubstituted or substituted once with R^(h); R^(b) is: hydrogen; or C₁₋₆alkyl; R^(c) is: hydrogen; C₁₋₆alkyl; halo-C₁₋₆alkyl; cyano-C₁₋₆alkyl; C₁₋₆alkylcarbonyl; hydroxy-C₁₋₆alkylcarbonyl; oxetanylcarbonyl; oxetanylsulfonyl; C₁₋₆alkylsulfonyl; C₁₋₆alkylsulfonyl-C₁₋₆alkyl; hydroxyl-C₁₋₆alkyl; C₁₋₆alkyoxy-C₁₋₆alkyl; C₃₋₆cycloalkyl which may be unsubstituted or substituted once with R^(h); C₃₋₆cycloalkyl-C₁₋₆alkyl wherein the C₃₋₆cycloalkyl may be unsubstituted or substituted once with R^(h); heterocyclyl selected from oxetanyl, azetidinyl, morpholinyl and tetrahydrofuranyl, each of which may be unsubstituted or substituted once or twice with R^(h); heterocyclyl-C₁₋₆alkyl wherein the heterocyclyl is selected from oxetanyl and azetidinyl, each of which may be unsubstituted or substituted once with R^(h); heteroaryl selected from pyrazinyl and triazolyl, each of which may be unsubstituted or substituted once or twice with R^(h); or heteroaryl-C₁₋₆alkyl wherein the heteroaryl is selected from pyrazinyl and triazolyl, each of which may be unsubstituted or substituted once or twicewith R^(h); or R^(b) and R^(c) together with the nitrogen atom to which they are attached may form heterocyclyl selected from azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, azepinyl, morpholinyl, thiomorpholinyl, and 1,1-dioxothiomorpholinyl, each of which heterocylcles may be unsubstituted or substituted once with R^(h); R^(d) is: C₁₋₆alkyl; hydroxy-C₁₋₆alkyl; C₁₋₆alkyoxy-C₁₋₆alkyl; aminocarbonyl-C₁₋₆alkyl; or heteroaryl selected from pyridinyl, pyrimidinyl and pyrazinyl; R^(e) is: hydrogen; C₁₋₆alkyl; or hydroxy-C₁₋₆alkyl; R^(f) is: hydrogen; C₁₋₆alkyl; halo-C₁₋₆alkyl; cyano-C₁₋₆alkyl; hydroxyl-C₁₋₆alkyl; C₁₋₆alkyoxy; C₁₋₆alkyoxy-C₁₋₆alkyl; C₁₋₆alkylsulfonyl-C₁₋₆alkyl; C₃₋₆cycloalkyl which may be unsubstituted or substituted once with R^(h); C₃₋₆cycloalkyl-C₁₋₆alkyl wherein the C₃₋₆cycloalkyl may be unsubstituted or substituted once with R^(h); heterocyclyl selected from oxetanyl, azetidinyl, morpholinyl and tetrahydrofuranyl, each of which may be unsubstituted or substituted once or twice with R^(h); heterocyclyl-C₁₋₆alkyl wherein the heterocyclyl is selected from oxetanyl and azetidinyl, each of which may be unsubstituted or substituted once with R^(h); heteroaryl selected from pyrazinyl and triazolyl, each of which may be unsubstituted or substituted once or twice with R^(h); or heteroaryl-C₁₋₆alkyl wherein the heteroaryl is selected from pyrazinyl and triazolyl, each of which may be unsubstituted or substituted once or twicewith R^(h); or R^(e) and R^(f) together with the nitrogen atom to which they are attached may form heterocyclyl selected from azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, azepinyl, morpholinyl, thiomorpholinyl, and 1,1-dioxothiomorpholinyl, each of which heterocylcles may be unsubstituted or substituted once with R^(h); R^(g) is: hydrogen; or C₁₋₆alkyl; R^(h) is: C₁₋₆alkyl; cyano; hydroxy; aminocarbonyl; oxo; or hydroxy-C₁₋₆alkyl.
 2. The compound of claim 1, wherein A is a six membered hetereoaryl selected from: pyridinyl; pyrimidinyl; and pyrazinyl.
 3. The compound of claim 1, wherein m is 0 or
 1. 4. The compound of claim 1, wherein R¹ and R² are fluoro.
 5. The compound of claim 1, wherein R³ is hydrogen.
 6. The compound of claim 1, wherein R⁴ is: C₁₋₆alkyl; oxo; halo; or cyano.
 7. The compound of claim 1, wherein R⁵ is: heteroaryl selected from pyridinyl, pyrimidinyl, oxadiazolyl, triazolyl, oxazolyl, tetrazolyl, imidazolyl, pyrazolyl, and isoxazolyl, each of which may be unsubstituted or substituted once or twice with R^(a); heterocyclyl selected from azetidinyl, oxetanyl, pyrrolidinyl, imidazolidinyl, morpholinyl, 1-oxa-6-azaspiro 3.3 heptanyl, piperazinyl, piperidinyl, and dihydropyridinyl, each of which may be unsubstituted or substituted once or twice with R^(a); —NR^(b)R^(c); —C(O)NR^(e)R^(f); or -hydroxy-C₁₋₆alkyl.
 8. The compound of claim 1, wherein R^(a) is: cyano-C₁₋₆alkyl; halo-C₁₋₆alkyl; hydroxy-C₁₋₆alkyl; hydroxy-C₁₋₆alkoxy; hydroxy-C₁₋₆alkyl substituted with halo; or hydroxy-C₁₋₆alkoxy substituted with halo.
 9. The compound of claim 1, wherein R⁵ is:


10. The compound of claim 1, wherein said compound is of formula III


11. The compound of claim 1, wherein said compound is of formula IV


12. The compound of claim 1, wherein said compound is of formula V


13. A composition comprising: (a) a pharmaceutically acceptable carrier; and (b) a compound of claim
 1. 14. A compound selected from: 